Navigation Links
Inhibiting Blood to Save the Brain

A fibrous protein called fibrinogen, found in circulating blood and important in blood clotting, can promote multiple sclerosis (MS) when it //leaks from the blood into the brain, triggering inflammation that leads to MS-related nerve damage. Researchers at the University of California, San Diego (UCSD) School of Medicine have identified a fibrin-derived peptide that inhibits this specific inflammation process in mouse models of MS, reducing MS symptoms.

“Current strategies to develop therapies to fight MS primarily target T cells,” said Katerina Akassoglou, Ph.D., assistant professor in UCSD’s Department of Pharmacology, whose study was published in the March 19 issue of Journal of Experimental Medicine. “Blood proteins have been neglected as a therapeutic target, but this research shows that a blood clotting factor is an important player in MS.”

MS is an inflammatory disease that affects the central nervous system, causing symptoms such as loss of balance and muscle coordination, and changes in cognitive function. The disease is marked by loss of myelin, a material that coats nerve fibers. Past studies showed that the destruction of the myelin sheath is associated with the accumulation of fibrinogen deposits in the brain of human MS patients. In this study, Akassoglou and colleagues showed that fibrinogen is not merely associated with the damage in MS, but an active participant. Fibrinogen activates macrophage cells in the brain called microglia, causing inflammation which damages myelin.

The scientists sought to design a therapeutic strategy that would block the damaging effects of fibrinogen without affecting its beneficial blood coagulation. Studying a mouse model, the researchers identified a specific receptor called Mac-1 that is expressed by microglial cells and binds to fibrinogen. Mice expressing a mutant form of fibrinogen that failed to bind Mac-1 had fewer inflammatory lesions and less severe MS symptoms. Blocking th e interaction between Mac-1 and fibrinogen after the first episode of paralysis using the fibrin peptide prevented subsequent relapses. It also prevented further microglia activation and damage to myelin in the diseased mice, allowing them to survive with improved motor function.

“Importantly, this approach blocks fibrin’s interaction with microglia, but not with platelets, so clotting wouldn’t be impacted,” said Akassoglou, adding that this potential MS therapy might also have applications to other blood-brain barrier diseases where blood leakage and microglia activation is present such as spinal cord injury, Alzheimer’s disease or stroke.

Source-Newswie
SRM
'"/>




Related medicine news :

1. Sugars Could Contain Key Cancer Inhibiting Compounds
2. Recommendations for Treatment of Blood Pressue
3. Blood Cells Capable of Regenerating Liver
4. Blood clots likely in long travel
5. Hemochromatosis Patients Blood is Safe
6. Blood transfusions beneficial after heart attacks
7. Blood Pressure Drug may slow wasting in burn victims
8. Levels Of Blood Proteins May Help Heart Disease Care
9. Blood test may identify ovarian cancer
10. A Blood test for suicide risk?
11. Blood Pressure Drugs maintain muscle strength
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/30/2016)... ... May 30, 2016 , ... Zane ... the publication of an original infographic, " Health Benefits Reimbursement Compliance Timeline ." ... how Zane Benefits complies with various federal regulations and reforms. , Navigating the ...
(Date:5/29/2016)... ... May 29, 2016 , ... Whole Health Supply is happy to announce the ... available via Amazon.com. This new style of nail clipper has a wider jaw opening ... approximately 4mm and the actual handle is 2.5mm thick to accommodate the cutting force. ...
(Date:5/28/2016)... ... May 28, 2016 , ... SuperCloset is proud to officially launch our ... to day issues, struggles and obstacles veterans’ need to overcome in order to face ... active or retired military veteran(s) with a donated SuperCloset product based on the needs ...
(Date:5/28/2016)... ... May 28, 2016 , ... After a year and a half of planning the ... event. The Multiple Pathways of Recovery Conference was held May 2 -4, 2016 at ... the United Kingdom came together to explore the many pathways individuals use to get into ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... Southland ... line of classic American timber frame barn kits, which can be found on its ... inspired by historic American barn plans, and they highlight the craftsmanship of timber post ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... 27, 2016 Hutchison China ... focused on the highly lucrative global oncology and ... of potential first-in-class or best-in-class tyrosine kinase inhibitor ... with strategic partners. HCM,s profitable Chinese healthcare business ... We expect progress of the mid-to-late-stage pipeline during ...
(Date:5/26/2016)... May 26, 2016 A key ... is the emergence of new treatments. Cardax, a development ... osteoarthritis treatment. The therapy is expected to fulfil large ... UK is conducting studies to develop new treatments for ... the genes involved in osteoarthritis are being investigated, and ...
(Date:5/25/2016)... 2016 According to a new ... 2D, 4D), by Therapeutic Area (Oncology, Cosmeceutical/Plastic Surgery), by ... Device Manufacturers, Hospitals/ Clinics) - Forecast to 2021", published ... Market for the forecast period of 2016 to 2021. ... by 2021 from USD 117.3 Million in 2016, at ...
Breaking Medicine Technology: