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Influenza Virus also Protects Against H5N1

uses that carried N1.

"Although the number of human donors in this study was limited, the results show that some individuals have levels of antibodies that are high enough to react against H5N1," Webby said.

If the initial findings of the St. Jude study are confirmed in the future, there may be a greater interest in examining the amount of neuraminidase in yearly influenza vaccines, according to Matthew Sandbulte, Ph.D., a postdoctoral fellow at the Food and Drug Administration, who did much of the work on this project.

"Hemagglutinin is more abundant than neuraminidase on viruses and is a better target for protective immunity, so current vaccines are designed to trigger immune responses mostly to hemagglutinin," Sandbulte said. "That is why vaccines contain standard amounts of hemagglutinin, but varying amounts of neuraminidase. But if further research confirms that the N1 part of the influenza vaccine offers some cross protection against H5N1, it will be desirable to have a better idea of the amount of N1 present in these vaccines."

An implication of the ability of N1 immunity conferring some degree of protection against H5N1 is that younger people who have a shorter history of exposure to the human influenza virus H1N1 might have less existing immune protection against this virus. "That could mean such people are more susceptible to H5N1 infection than adults," Sandbulte said.

Source-Eurekalert
PRI
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