Navigation Links
Influence Of Heart Rate On Myocardial Oxygen Tension

The influence of heart rate on cardiac output, oxygen consumption, and myocardial activity has been widely investigated.// However, the influence of heart rate on myocardial oxygen tension (pO2) remains unclear. Since the introduction of flexible pO2 micro catheters to measure partial oxygen tension in a working muscle, it is possible to investigate the influence of heart rate on myocardial oxygen tension.

In a recent study, researchers from Germany examined the effect of a changing heart rate on myocardial oxygen tension. The study was done also to evaluate a possible threshold value for an ideal heart rate at which myocardial oxygen tension (pO2) is optimal. Furthermore, the time frame of response of pO2 to a change in heart rate was analyzed. These questions were addressed in an animal model using flexible pO2 probes.

For the study, to be published in the journal Microvascular Research, intraoperatively, a flexible pO2 micro catheter was positioned in the mid-myocardium of 8 male farm pigs. The heart rate was varied via an external pacer from base rate up to fibrillation and the corresponding myocardial pO2 was measured.

The researchers found that within 2 min, the myocardial pO2 adjusted to a change in heart rate. In this animal model, an optimal myocardial pO2 was observed at 109 bpm. A further increase in heart rate led to a decrease in myocardial pO2. Each change in heart rate resulted in a corresponding change of pO2 within roughly 2 min. When the heart rate was reaching the level of a fibrillation, pO2 dropped to zero.

Left ventricular ischemia with subsequent necrosis of myocardium is the most important factor for postoperative myocardial insufficiency leading to death or myocardial dysfunction after open-heart surgery. Myocardial oxygen tension is depending on several factors such as coronary perfusion pressure, metabolic need, heart rate, and tenacity of the coronary vessels. An increasing heart rate starting from a base rate results in an increasing cardiac output but to a higher oxygen consumption also. However, up to now, it remained unclear how partial myocardial oxygen pressure relates to a change in heart rate.

In this study, in young healthy pigs – with a normal blood vessel regulation and the pharmacologic and experimental conditions used in this study – a significant relation between myocardial pO2 and heart rate was observed. In a working, fully loaded heart, fibrillation resulted in a partial oxygen tension of around zero and death of the animal.

Medindia on Chest pain: Chest pain is a common symptom which can be caused by many different conditions. Some causes of chest pain require prompt medical attention, such as angina, heart attack, or tearing of the aort.

Related medicine news :

1. Diet Can Influence Allergic Skin Reactions
2. Influence of diet on allergic Reactions
3. Alcoholism Influenced By Both Genetics & Family Environment
4. Hunger Found To Influence Taste
5. Body Weight Found To Influence PSA Levels
6. Depressed Mothers Found To Influence Their Child’s Behavio
7. Childhood Obesity May Influence The Their Quality Of Life
8. Elevated Insulin Levels To Influence Levels Of Inflammatory Markers
9. Vitamins Found To Influence Birth Weight
10. Influence of Celebrities on Breast Cancer Awareness
11. Genetic Expressions Can Influence The Process Of Aging
Post Your Comments:

(Date:10/13/2017)... ... October 13, 2017 , ... As health professionals work ... as “patient engagement.” The patient is doing more than filling out a survey; in ... “There is an increasing emphasis in health care and research on the importance of ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with ... for the primary prevention of cardiovascular diseases during the 15th Annual Women’s ...
(Date:10/13/2017)... ... 2017 , ... Ellevate Network, the leading network for professional women, brought together ... equality at their inaugural Summit in New York City in June. The event was ... of over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed a ... and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been ... standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading global ... that its MyDario product is expected to appear on The Dr. Oz ... Dr. Oz Show airs in your area: ... The nine-time Emmy award-winning, The Dr. Oz Show kicked ... The segment features ...
(Date:9/22/2017)... AVACEN Medical (AVACEN) announced that its CE-Marked ... those with the widespread pain associated with fibromyalgia in ... Essex, England commented, "I had ... no sleep at all, tremendous pain, with every movement ... [the AVACEN 100] enough, how this has and is ...
(Date:9/13/2017)...   OrthoAtlanta has been named the official orthopedic ... (AFHC) for the 2018 College Football Playoff (CFP) National Championship ... Stadium in Atlanta, Georgia . OrthoAtlanta is ... campaign, participating in many activities leading up to, and including ... ...
Breaking Medicine Technology: