Navigation Links
Influence Of Heart Rate On Myocardial Oxygen Tension

The influence of heart rate on cardiac output, oxygen consumption, and myocardial activity has been widely investigated.// However, the influence of heart rate on myocardial oxygen tension (pO2) remains unclear. Since the introduction of flexible pO2 micro catheters to measure partial oxygen tension in a working muscle, it is possible to investigate the influence of heart rate on myocardial oxygen tension.

In a recent study, researchers from Germany examined the effect of a changing heart rate on myocardial oxygen tension. The study was done also to evaluate a possible threshold value for an ideal heart rate at which myocardial oxygen tension (pO2) is optimal. Furthermore, the time frame of response of pO2 to a change in heart rate was analyzed. These questions were addressed in an animal model using flexible pO2 probes.

For the study, to be published in the journal Microvascular Research, intraoperatively, a flexible pO2 micro catheter was positioned in the mid-myocardium of 8 male farm pigs. The heart rate was varied via an external pacer from base rate up to fibrillation and the corresponding myocardial pO2 was measured.

The researchers found that within 2 min, the myocardial pO2 adjusted to a change in heart rate. In this animal model, an optimal myocardial pO2 was observed at 109 bpm. A further increase in heart rate led to a decrease in myocardial pO2. Each change in heart rate resulted in a corresponding change of pO2 within roughly 2 min. When the heart rate was reaching the level of a fibrillation, pO2 dropped to zero.

Left ventricular ischemia with subsequent necrosis of myocardium is the most important factor for postoperative myocardial insufficiency leading to death or myocardial dysfunction after open-heart surgery. Myocardial oxygen tension is depending on several factors such as coronary perfusion pressure, metabolic need, heart rate, and tenacity of the coronary vessels. An increasing heart rate starting from a base rate results in an increasing cardiac output but to a higher oxygen consumption also. However, up to now, it remained unclear how partial myocardial oxygen pressure relates to a change in heart rate.

In this study, in young healthy pigs – with a normal blood vessel regulation and the pharmacologic and experimental conditions used in this study – a significant relation between myocardial pO2 and heart rate was observed. In a working, fully loaded heart, fibrillation resulted in a partial oxygen tension of around zero and death of the animal.

Medindia on Chest pain: Chest pain is a common symptom which can be caused by many different conditions. Some causes of chest pain require prompt medical attention, such as angina, heart attack, or tearing of the aort.
'"/>




Related medicine news :

1. Diet Can Influence Allergic Skin Reactions
2. Influence of diet on allergic Reactions
3. Alcoholism Influenced By Both Genetics & Family Environment
4. Hunger Found To Influence Taste
5. Body Weight Found To Influence PSA Levels
6. Depressed Mothers Found To Influence Their Child’s Behavio
7. Childhood Obesity May Influence The Their Quality Of Life
8. Elevated Insulin Levels To Influence Levels Of Inflammatory Markers
9. Vitamins Found To Influence Birth Weight
10. Influence of Celebrities on Breast Cancer Awareness
11. Genetic Expressions Can Influence The Process Of Aging
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: