Navigation Links
Inflammation can Lead to Cancer

Previous studies have shown that inflammation may sometimes cause precancerous tissues to become fully malignant. UCSF scientists// have now discovered what triggers this potentially deadly process. Typically, the "innate" immune system's Pac-Man-like white blood cells, or leukocytes, engulf and destroy invading microbes when receptors on their surface receive a signal from serum in the blood -- often an antibody produced by a B cell in the separately evolved "acquired" immune system.

Now UCSF researchers have found that in the presence of precancerous tissue, leukocyte antibody receptors can also be activated to turn on a dangerously different program: inducing leukocytes to boost cell growth, increase the number of blood vessels and "remodel" tissue in the area -- all of which help cancer develop.

The finding adds a critical and surprising detail to the emerging view that inflammation, usually a helpful response to invading pathogens, can become misdirected and fuel cancer.

The new research was presented today (February 19) by UCSF scientist Lisa M. Coussens, PhD, at the annual meeting of the American Association for the Advancement of Science (AAAS) in a session titled "healthy aging: inflammation and chronic diseases."

"Immunologists have known for decades that B cells of the so-called adaptive or acquired immune system are activated following a bacterial infection and in response, produce antibodies that signal leukocytes to attack," said Coussens, associate professor of pathology in the UCSF Cancer Research Institute.

"But in precancerous tissue in mice, we have found that leukocytes apparently receive signals to switch programs, stimulating cell growth and increasing blood supply -- processes that would normally help healing from an infection, but can instead fuel cancer cell development."

The researchers have not yet identified what specific signal or signals are involved, but preliminary
'"/>




Page: 1 2

Related medicine news :

1. Inflammation may help battle infection in gums
2. Inflammation Linked to Colon Cancer
3. Bee Venom Effective In Reducing Inflammation
4. Inflammation reduced by consuming oily fish
5. Research Shows Carbon Monoxide Prevents Inflammations
6. ‘Inflammation Gene’ identified by scientit
7. High-Fat Diet Can Ward Off Inflammation In The Gut
8. Inflammation May Indicate Heart Problems
9. Inflammation and WBC count has a link to deaths by cancer
10. Mediterranean Diet Lowers Inflammation Levels In Elderly
11. PET Scans Help In Monitoring Progress of Lung Inflammation
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Inflammation can Lead Cancer

(Date:3/3/2015)... (PRWEB) March 03, 2015 Today, Steve ... former Seattle Seahawks wide receiver, announced the donation of ... timing with Brain Injury Awareness Month. In an effort ... and the importance of brain health, Rice and Weatherford ... and the need to make brain health a priority ...
(Date:3/3/2015)... Angeles, Ca (PRWEB) March 03, 2015 Dan ... with a special focus on capital crimes, recently spoke ... “American Sniper” murder trial. The hosts of the Independent Journal ... knew his history working first as a prosecutor and now ... insight into the decisions made in the trial and sentencing ...
(Date:3/3/2015)... The human augmentation market is mainly driven by ... augmentation sector is predicted to outpace the in-built augmentation ... , The eye-wear sector dominates the North American ... new products launches in the region. Furthermore, strong economy ... well as the rising demand for advantageous products in ...
(Date:3/3/2015)... While it is clear that the prospect ... Canadian drivers are signing up to UBI policies, more ... be enticed. Due to current regulations, the application of ... Its full capability is starting to be realised ... emergency breakdown services are at the top of the ...
(Date:3/3/2015)... 03, 2015 DePuy Pinnacle hip ... version of the artificial hip system caused recipients ... move forward in the federal multidistrict litigation underway ... According to the most recent Master Case List ... 7,350 Pinnacle hip replacement lawsuits are now pending ...
Breaking Medicine News(10 mins):Health News:Steve Weatherford and Sidney Rice Reveal Donation for Brain Injury Awareness Month 2Health News:Dan E. Chambers Gives Radio Interview Providing Insights into American Sniper Guilty Verdict 2Health News:Dan E. Chambers Gives Radio Interview Providing Insights into American Sniper Guilty Verdict 3Health News:Human Augmentation Market to Pose 43.5% CAGR Through 2020, States MarketsandMarkets in its New Research Study Now Available at MarketPublishers.com 2Health News:TU-Automotive: Wawanesa Insurance to Discuss How UBI Can Produce Happy, Loyal Customers 2Health News:DePuy Pinnacle Lawsuit News: Bernstein Liebhard LLP Comments on Growing Pinnacle Hip Litigation 2Health News:DePuy Pinnacle Lawsuit News: Bernstein Liebhard LLP Comments on Growing Pinnacle Hip Litigation 3Health News:DePuy Pinnacle Lawsuit News: Bernstein Liebhard LLP Comments on Growing Pinnacle Hip Litigation 4
... has directed the state prisons department to provide ayurvedic treatment ... 1998// serial blasts Abdul Nasser Mahdhani in the central prison ... arrest in March 1998, 45 days after the serial blasts, ... blood pressure, diabetes, spinal proble and weight loss. He also ...
... of India wants the Government and people to work together ... donation. In India., ,Inaugurating the blood bank of ... asked the government and people to work in tandem for ... organs must be encouraged to save precious lives, especially that ...
... gene that facilitates the spread of malignant melanoma, a ... speed the discovery of hard-to-find cancer genes. ,A ... Lynda Chin, MD, report that the gene, NEDD9, is ... that have metastasized, but not in primary melanomas that ...
... subject as sex is, perhaps vying with each other for ... known - responsible //for many diseases, failed pregnancy, miscarriage, etc. ... host of problems, like ADHD in the child and premature ... memory and hormonal cycles. ,Women seem to be twice ...
... that the antipsychotic drug, clozapine has some very concerning ... available. ,"Clozapine is the last hope for ... study suggests that patients who need the most effective ... said J. Steven Lamberti, the lead author of the ...
... Paris have concluded that at least one decade is needed ... Dr. David Fedson, former professor// of medicine at the University ... was nothing short of a catastrophe for the public. ... work with for three years and after three years this ...
Cached Medicine News:Health News:Researchers have Identified the Gene that Spreads Skin Cancer 2
(Date:3/3/2015)... 3, 2015  Web Industries, Inc., a leading ... the Medical Device, Advanced Composites, Consumer Products, and ... 3M Medical Specialties Preferred Converter by 3M,s Medical ... companies to streamline their supply chains by using ... 3M materials, intermediate converting services, and contract manufacturing ...
(Date:3/3/2015)... 03, 2015 Research and Markets ... the "Telemedicine and Mobile Healthcare Solutions, Services, ... 2020" report to their offering. ... all terms that pertain to the use of ... remote clinical/non-clinical healthcare services. They form the ecosystem ...
(Date:3/3/2015)... , March 3, 2015 Today, the ... sponsored by America,s biopharmaceutical research companies, unveiled a ... functionality to provide patients and caregivers with faster, ... public and private patient assistance programs. ... provided a platform to engage, educate and empower ...
Breaking Medicine Technology:Web Industries Receives 3M Preferred Converter Status 2Global Telemedicine and Mobile Healthcare Solutions, Services, and Devices: Market Analysis and Forecasts 2015 - 2020 2Global Telemedicine and Mobile Healthcare Solutions, Services, and Devices: Market Analysis and Forecasts 2015 - 2020 3Partnership for Prescription Assistance Relaunches Website with New Features for Patients and Caregivers 2
... LAWRENCE, Mass., Jan. 4, 2011 NxStage Medical, Inc. ... innovative dialysis products, today announced that Jeffrey H. Burbank, ... Officer, will present at the 29th Annual J.P. Morgan ... a.m. (PST). The live webcast of NxStage,s ...
... Pharmaceuticals, Inc. (Nasdaq: OPTR ) today announced ... granted orphan drug designation from the U.S. Food and ... Clostridium difficile infection (CDI).  This orphan drug designation ... of fidaxomicin used to treat Clostridium difficile ...
Cached Medicine Technology:NxStage to Present at the 29th Annual J.P. Morgan Healthcare Conference 2Optimer Pharmaceuticals Receives Orphan Drug Designation for Fidaxomicin for the Treatment of Pediatric Clostridium difficile Infection 2Optimer Pharmaceuticals Receives Orphan Drug Designation for Fidaxomicin for the Treatment of Pediatric Clostridium difficile Infection 3Optimer Pharmaceuticals Receives Orphan Drug Designation for Fidaxomicin for the Treatment of Pediatric Clostridium difficile Infection 4
... for applications in the field of point of ... used as a back-up instrument in routine pathology ... safety clamps for the cover, the CM1100 can ... optional 12-volt transformer, it can be run on ...
The HM 550 series is a uniquely progressive concept for use with frozen specimens of all types. User applications define module selection and make even serial sectioning enjoyable....
... advanced smart processor for paraffin infiltration of ... Proven and enhanced technology with an innovative ... the hallmark of the Leica ASP200. Many ... includes a variety of SMART features to ...
... A totally new concept in a power ... and sliding microtomes. Power assisted horizontal movements ... moving across the knife edge. Duplicate controls ... or right hand while the operating levers ...
Medicine Products: