Navigation Links
Inflammation Linked to Colon Cancer

Inflammation may play a significant role in the development of colon cancer, find researchers publishing in an early online edition of the Proceedings of the National Academy of Sciences. //

Research has shown a role for inflammation in many types of cancer. Most of these studies link the condition to oxidative stress, which in turn causes mutations in specific genes. In this study, investigators from Vanderbilt Institute of Chemical Biology built on this previous work with a study aimed at determining whether the genetic damage resulting from chronic inflammation, called oxidative stress, is limited to the specific cells that are damaged, or whether it invades the cell's DNA as well and thus is passed on to new cells.

Study author Lawrence J. Mamett, Ph.D., explains, "When the body experiences oxidative stress, molecules called free radicals are produced, and these free radicals can damage cells -- the cell membrane and the DNA."

The laboratory study involved a type of DNA damage caused by a product of the COX-2 enzyme, which is known to play a role in inflammation and is blocked by aspirin and other drugs known as COX-2 inhibitors. Researchers took the damaged DNA molecule and inserted it into mammalian kidney cells to see if it would replicate, and it did. The mutations seen in the study are similar to those known to cause an inherited form of colon cancer.

The investigators conclude chronic inflammation causes genetic abnormalities that might lead to cancer.
'"/>




Page: 1

Related medicine news :

1. Inflammation may help battle infection in gums
2. Bee Venom Effective In Reducing Inflammation
3. Inflammation reduced by consuming oily fish
4. Research Shows Carbon Monoxide Prevents Inflammations
5. ‘Inflammation Gene’ identified by scientit
6. High-Fat Diet Can Ward Off Inflammation In The Gut
7. Inflammation May Indicate Heart Problems
8. Inflammation and WBC count has a link to deaths by cancer
9. Mediterranean Diet Lowers Inflammation Levels In Elderly
10. PET Scans Help In Monitoring Progress of Lung Inflammation
11. Single Sugar Enables Antibody to Treat Inflammation
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/24/2017)... ... 2017 , ... SignatureCare Emergency Center is looking to award their ... to a deserving student. Get your applications in now as the deadline is ... Castillo who is a nursing student at Prairie View A&M University with a 3.45 ...
(Date:7/24/2017)... , ... July 24, 2017 , ... ... Oakland, California effectively destroyed the construction site and threatened numerous homes and businesses ... 7th article on NBCLosAngeles.com. Los Angeles Area consulting firm Fire Protection ...
(Date:7/24/2017)... CLARA, CA (PRWEB) , ... July 24, 2017 , ... ... and financial organizations, today announced it has partnered with WALLIX to expand ... Special Publication 800-171 . , There are a number of ways to address the ...
(Date:7/24/2017)... California (PRWEB) , ... July 24, 2017 , ... ... of autologous fat (adipose) transfer systems announces the issuance of United States Patent ... patent) for its adipose filtration technology. The '398 and '324 patents cover ...
(Date:7/24/2017)... , ... July 24, 2017 , ... ... sleep management solution focused on delivering end-to-end sleep health care at scale, ... Recent literature shows that adherence rates for positive airway pressure (PAP) therapy, the ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... and EDMONTON, Alberta , July ... and the University of Alberta in ... in Nature,s partner journal, Schizophrenia 1 , demonstrating ... instances of schizophrenia with 74% accuracy. This retrospective ... of specific symptoms in schizophrenia patients with significant ...
(Date:7/21/2017)... , July 21, 2017  Endo International plc (NASDAQ: ... a comprehensive review of its manufacturing network, the Company ... distribution facilities in Huntsville, Alabama . ... place over the next 12 to 18 months. The ... by declining volumes of commoditized products and these restructuring ...
(Date:7/20/2017)... , July 20, 2017  Prime Therapeutics LLC (Prime) ... Gavras , M.D., following today,s Institute for Clinical and Economic ... on the effectiveness and value of abuse-deterrent formulations (ADF) ... the policy roundtable at the meeting. ... a material cost benefit to the use of abuse-deterrent formulations ...
Breaking Medicine Technology: