Navigation Links
Inflammation Linked to Colon Cancer

Inflammation may play a significant role in the development of colon cancer, find researchers publishing in an early online edition of the Proceedings of the National Academy of Sciences. //

Research has shown a role for inflammation in many types of cancer. Most of these studies link the condition to oxidative stress, which in turn causes mutations in specific genes. In this study, investigators from Vanderbilt Institute of Chemical Biology built on this previous work with a study aimed at determining whether the genetic damage resulting from chronic inflammation, called oxidative stress, is limited to the specific cells that are damaged, or whether it invades the cell's DNA as well and thus is passed on to new cells.

Study author Lawrence J. Mamett, Ph.D., explains, "When the body experiences oxidative stress, molecules called free radicals are produced, and these free radicals can damage cells -- the cell membrane and the DNA."

The laboratory study involved a type of DNA damage caused by a product of the COX-2 enzyme, which is known to play a role in inflammation and is blocked by aspirin and other drugs known as COX-2 inhibitors. Researchers took the damaged DNA molecule and inserted it into mammalian kidney cells to see if it would replicate, and it did. The mutations seen in the study are similar to those known to cause an inherited form of colon cancer.

The investigators conclude chronic inflammation causes genetic abnormalities that might lead to cancer.
'"/>




Page: 1

Related medicine news :

1. Inflammation may help battle infection in gums
2. Bee Venom Effective In Reducing Inflammation
3. Inflammation reduced by consuming oily fish
4. Research Shows Carbon Monoxide Prevents Inflammations
5. ‘Inflammation Gene’ identified by scientit
6. High-Fat Diet Can Ward Off Inflammation In The Gut
7. Inflammation May Indicate Heart Problems
8. Inflammation and WBC count has a link to deaths by cancer
9. Mediterranean Diet Lowers Inflammation Levels In Elderly
10. PET Scans Help In Monitoring Progress of Lung Inflammation
11. Single Sugar Enables Antibody to Treat Inflammation
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best ... individuals in the United States and Canada wear eyeglasses. Once considered to be a ... and make a fashion statement. Even celebrities use glasses as a way of creating ...
(Date:6/26/2016)... ... ... Kasmer, a legally blind and certified personal trainer is helping to develop a weight loss ... plans to fix the two major problems leading the fitness industry today:, ... , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Conventional wisdom ... of success. In terms of the latter, setting the bar too high can result ... more than just slow progress toward their goal. , Research from PsychTests.com ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in ... . ... ... ... Astellas is ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
(Date:6/23/2016)... -- Research and Markets has announced the ... (United States, China, Japan, Brazil, United Kingdom, Germany, France, ... Surgical Procedure Volumes: ... provides surgical procedure volume data in a geographic context. ... analysis of growth drivers and inhibitors, including world population ...
Breaking Medicine Technology: