Navigation Links
Infertility is Seen in Men With SLE

The prognosis for systemic lupus erythematosus (SLE), an autoimmune disease that mainly affects women in their reproductive years , has improved recently, prompting a shift toward improving quality of life.

For men with SLE, concerns have been raised about their future fertility. However, no studies have been conducted to date on testes function and its relevance to sperm abnormalities in male SLE patients. In addition, the study identified intravenous treatment with the immunosuppressant cyclophosphamide (IV CYC) as the major factor in permanent damage to the testes.

Led by Polyanna Maria , Brazil, the study included 35 men with SLE and 35 healthy controls, who underwent an exam of the genitalia, and semen analysis to determine sperm count, morphology and motility. For SLE patients, analysis of antisperm antibodies (which can adversely affect fertilization), testicular ultrasound, and hormone evaluation were also conducted.

The results showed that SLE patients had lower median testicular volumes in both testes, compared with controls, a lower median sperm count, and lower motility. SLE patients also had lower sperm volume and a lower percentage of normally formed sperm.

Since all SLE patients had some type of semen abnormality, they were divided into two groups according to the severity: group 1 had abnormal sperm morphology, while group 2 had no sperm or abnormal sperm morphology, coupled with low sperm count and/or low sperm motility. Those in group 2 had a higher frequency of treatment with IV CYC than those in group 1, along with lower testicular volumes and higher levels of follicle-stimulating hormone.

To our knowledge, this is the first systematic evaluation that has specifically addressed sperm abnormalities in SLE and that clearly demonstrates a high frequency of severe alterations, the researchers state, adding that the study also identifies IV CYC treatment given after puberty as the major factor in permanent sperm damage.

IV CYC induces long-lasting damage to developing sperm cells that leads to significant semen alterations. The researchers note that the striking reduction of testicular volumes paralleled the severity of sperm abnormalities, suggesting severe damage to the seminiferous tubules (the tiny tubes in which sperm are produced) in SLE.

Follicle-stimulating hormone (FSH) is a major marker of the function of the cells lining the seminiferous tubules and its higher levels in the group 2 SLE patients suggest testicular damage.

The researchers point out that although it is not possible to predict which SLE patients will become infertile, the persistence of abnormal testicular function after approximately five years of IV CYC treatment, combined with elevated FSH and lower testicular volumes, reinforces the need for sperm cryopreservation for male SLE patients undergoing this treatment.

Freezing and storing sperm should actually be discussed with all male SLE patients early in the disease course, since for almost a third of patients with semen alterations, the cause has not been recognized. The researchers conclude: Considering that this disease occurs mainly during reproductive age, a multi-disciplinary approach is essential to identify the potential risk factors for infertility and to offer preventive measures for these patients.


'"/>




Related medicine news :

1. Infertility in relation with virus
2. Infertility may result from bone fragments
3. Breast Cancer Survivors Worry About Infertility
4. Breast Cancer Survivors Worry About Infertility
5. Hormone Leptin Found To Be Effective In Treating Women With Infertility Problems
6. Effectiveness Of Infertility Treatments Questioned
7. Stem Cell Solution for Infertility
8. Infertility Associated With Increased Cancer Risk
9. Knowledge Of Infertility Gets New Inputs
10. New Discovery May Help Treat Infertility
11. New Infertility test to be offered by Reliance
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2016)... ... 02, 2016 , ... ‘Tis the season for giving! Today, 20 creative teams ... Family Partnership and the Drug Enforcement Administration as part of the National Red Ribbon ... winning schools who decorated their campuses with this year’s Red Ribbon Week theme: “YOLO. ...
(Date:11/30/2016)... ... November 30, 2016 , ... Northridge ... in-house dental plan for all patients. Understanding that budget can play a part ... a number of perks, including discounts on many valuable dental treatments. Options for ...
(Date:11/30/2016)... Wisconsin (PRWEB) , ... November 30, 2016 , ... ... in the 2016 Deloitte Wisconsin 75, an annual ranking and recognition of the ... year on the list, having ranked from 2008-2016. In addition, Standard Process was ...
(Date:11/30/2016)... (PRWEB) , ... November 30, 2016 , ... ... and mental health treatment has announced the opening of a new residential mental ... for girls with mental health issues such as severe anxiety, depression, bi-polar disorder, ...
(Date:11/30/2016)... ... November 30, 2016 , ... The ... stylish design wanted by today’s consumers at an affordable price, is now available ... the new watch is “a game changer” when it comes to the smartwatch. ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... , December 2, 2016 ... "In Vitro Diagnostics/IVD Market by Product (Instruments, Reagents, ... Application (Diabetes, Oncology, Cardiology, Nephrology, Infectious Diseases) - ... market is valued at USD 60.22 Billion in ... a CAGR of 5.5% during the forecast period ...
(Date:12/2/2016)... 2016  The Addiction Treatment Advisory Group (ATAG), ... Care Pharmacy (AMCP), has released detailed findings on ... opioid addiction crisis, including through improved access to ... ATAG,s newly released paper, "The Role of Managed ... many issues around gaps and barriers to addiction ...
(Date:12/2/2016)... 2, 2016 Boston Scientific Corporation (NYSE: ... acquire certain manufacturing assets and capabilities of the Neovasc, ... biological tissue business, as well as a 15% equity ... in cash. The Neovasc advanced biological tissue business makes ... Scientific Lotus™ Valve System. * Upon completion of ...
Breaking Medicine Technology: