Navigation Links
Infertility Breakthrough With First Birth from Lab-matured Egg

The first baby to be created from an egg matured in a laboratory, frozen, thawed and then fertilised, has been born in Canada, researchers told a medical conference on Monday.

The baby girl was born to a woman diagnosed with advanced ovarian disease, and three other women in the 20-person trial group are pregnant by the same technique, researchers said.

Doctors already collect and store eggs from women who face cancer treatment that could cause sterility.

The eggs -- harvested after stimulating the ovaries with hormones -- are fertilised in-vitro with their partner's sperm, then frozen. After the cancer therapy, the eggs are then thawed and implanted.

The Canadian team said the prototype technique took this fertility preservation a major step further. The eggs were recovered from unstimulated ovaries and in addition were fertilised after they had been frozen and then thawed, and not before.

"Until now, it was not known whether oocytes (human eggs) collected from unstimulated ovaries, matured in vitro and then vitrified could survive thawing, be fertilised successfully and result in a viable pregnancy after embryo transfer," said Hananel Holzer, who led the team from the McGill Reproductive Center in Montreal.

"We have demonstrated for the first time that it is possible to do this and, so far, we have achieved four successful pregnancies, one of which has resulted in a live birth. The other three pregnancies are ongoing."

The breakthrough was announced at the annual conference of the European Society of Human Reproduction and Embryology (EHSRE), meeting in this southeastern French city.

The trial group comprised 20 women, whose average age was about 30, who had been diagnosed by ultrasound to have polycystic ovarian syndrome (PCOS), a fertility-threatening hormonal disorder that affects around 10 percent of all women of child-bearing years.

A total of 296 eggs were collected from the patients, of which 290 were immature, ESHRE said in a press release.

They were then matured in the laboratory for 24-48 hours, and were frozen for several months and then thawed. Of these, 148 oocytes survived the thawing process and were fertilised by a technique called intra-cytoplasmic sperm injection.

Sixty-four embryos were then transferred to the women, who received multiple embryos in order to boost the chance of a successful pregnancy.

Holzer said his team had progressively improved the success rate, noting that three of the pregnancies had been achieved in the past five patients.

But he cautioned against giving rise to false hopes. The research is still in its preliminary stages and had not yet been proven in cancer patients, the biggest potential beneficiaries.

Women who face chemotherapy or radiotherapy for cancer may not have time to undergo ovarian stimulation so that their oocytes can be harvested and stored.

Their only other option for preserving their fertility is the still-experimental option of having ovarian tissue removed before they undergo cancer therapy.

The tissue is frozen and then transplanted back at a later date, although some experts worry that this may also reimplant cancer cells.

For women who are infertile with PCOS, taking hormones to stimulate egg production can lead to potentially fatal overstimulation of the ovaries.

Thus, obtaining immature eggs from unstimulated ovaries, and then coaxing them towards a pregnancy, is a major step forward for patients in this group.

Separately, ESHRE reported that scientists in Israel had been able to obtain and freeze eggs from the ovarian tissue of girls as young as five years old.

Childhood cancers usually result in cure rates of between 70 and 90 percent, but sometimes this comes at the cost of infli cting sterility when the child reaches adult life.

Obstetrician Ariel Revel of the Hadassah University Hospital, Jerusalem, found eggs in the ovarian buds of pre-pubescent girls aged between five and 10 years.

The eggs were gently sucked out using a needle, were matured in a lab dish and then frozen, for potential use in the future.


Related medicine news :

1. Infertility in relation with virus
2. Infertility may result from bone fragments
3. Breast Cancer Survivors Worry About Infertility
4. Breast Cancer Survivors Worry About Infertility
5. Hormone Leptin Found To Be Effective In Treating Women With Infertility Problems
6. Effectiveness Of Infertility Treatments Questioned
7. Stem Cell Solution for Infertility
8. Infertility Associated With Increased Cancer Risk
9. Knowledge Of Infertility Gets New Inputs
10. New Discovery May Help Treat Infertility
11. New Infertility test to be offered by Reliance
Post Your Comments:

(Date:10/9/2015)... ... , ... With the FCPX LUT Vibrance pack from Pixel Film Studios, editors ... Lookup Table that contains a mathematical formula for modifying an image. The LUT changes ... with 60 vibrant CUBE LUT files. , Inspired by many YouTube make-up ...
(Date:10/9/2015)... ... 09, 2015 , ... Dentist in Huntington Beach , ... that uses clear, plastic aligners. This alternative to braces has become wildly popular ... patients to complete treatment in privacy. Additionally, Invisalign aligners are removable, so patients ...
(Date:10/9/2015)... Stockton, CA (PRWEB) , ... October 09, 2015 ... ... year anniversary of their “Agents of Change” program, a community improvement initiative that ... The newest charity to benefit from the assistance of Confidence Plus Insurance is ...
(Date:10/9/2015)... ... October 09, 2015 , ... ViewPoint Center, a teen mental health hospital ... mental illness, the stigma associated with mental illness causes many to hide away in ... importance of supporting teens with mental illness , providing teens with comprehensive diagnostic ...
(Date:10/9/2015)... ... , ... Most people assume that Chinese food is more nutritious than American ... T’ai Chi Master and integrative medicine guru Steven Aung, MD agrees with that assessment, ... that they potentially complement one another, with each supplying nutritional elements the other may ...
Breaking Medicine News(10 mins):
... Sales and Marketing Veteran to Drive International Retail Expansion, ... Group and New WrinkleFree Brand Line ExtensionIRVINE, Calif., Jan. ... developer and distributor of medically developed and efficacy-based skin ... mass market retail locations throughout the U.S., announced today ...
... The following statement can be attributed to Michael ... has consistently said two things: We are not ... But we have urged public policy makers to ... merger without conditions, because without conditions the merger ...
... (Nasdaq: OMCL ), a leading provider of system solutions to acute healthcare ... quarter 2008 financial results. , What: Omnicell ... webcast, When: January ... Lipps, chairman, president and chief executive officer, ...
... Maine, Jan. 21 IDEXX Laboratories, Inc. (Nasdaq: ... quarter and full-year financial results for Friday, January 30, at ... conference call beginning at 9:00 a.m. (eastern) on that day. ... through a link on the IDEXX Web site, ...
... can lead to failure, , , WEDNESDAY, Jan. 21 (HealthDay ... a common cause of kidney transplant failure may help ... polyomavirus nephropathy, which affects about 9 percent of kidney ... adults but can cause serious problems for people with ...
... CAMBRIDGE, Mass. -- Schizophrenia may blur the boundary between ... that is involved in self-reflection, and thus causing an ... brain imaging study has found. , The traditional ... and emotions that characterize the disease are caused by ...
Cached Medicine News:
(Date:10/9/2015)... , October 9, 2015 ClinicalKey ... 7-9   Elsevier , ... and services, today launched ClinicalKey for Nursing , a ... tailored to meet the unique needs of nursing professionals. Attendees ... Atlanta , Oct. 7-9, will have the opportunity ...
(Date:10/9/2015)... 9, 2015 Eli Lilly and Company (NYSE: ... and approximately 50 new jobs to its research and development ... New York, New York . ... space will include a translational immuno-oncology hub and a Lilly ... collaborative access to cutting-edge drug discovery capabilities, including chemistry and ...
(Date:10/9/2015)... 2015 Der " JCA-Mauvernay Award ... Kondo und Dr.   Junko Takita    --> ... geht an Dr.   Yutaka Kondo und Dr. ... " JCA-Mauvernay Award   2015 " geht ... Takita    ™ , das weltweit tätige Schweizer Biopharmazieunternehmen, ...
Breaking Medicine Technology:
... DIEGO, May 2, 2012  Trovagene, Inc. (Pink Sheets: ... initiated development of a diagnostic test to determine the ... from urine specimens. The proprietary test (U.S. patent application ... determination of carrier status in males. The ...
... 2, 2012 Official journal of the American ... world-leading provider of scientific, technical and medical information products and ... the American Association for Geriatric Psychiatry (AAGP) to ... ( AJGP ) beginning in January 2013. ...
Cached Medicine Technology:
... 4 Dot with 955R Red/Green glasses ... presence of binocular vision. Consists of ... discs: two green, one red and ... any distance. Patient wears red/green glasses ...
20 foot distance 22-1/2" X 11-1/2". This test for illiterate patients has HOTV letters on one side and Allen figures on the other....
Angled 30 degree shaft. 13 mm from tip to bend with 2.5 mm hook curved tip. Polished finished. Overall length excluding hub: 35 mm, 1.4 inches....
McIntyre-Binkhorst, length 18 mm....
Medicine Products: