Navigation Links
Infant Formula With High Iron Content Packs Brain Disorder

Infant formula contains 12 times more iron compared to breast milk, suggests a research of Buck Institute. Neuro degeneration, seen in Parkinson’s disease can be caused// due to high intake of iron in infancy – finds a study with neonatal mice which was fed with human equivalent iron supplementation from human infant formula.

Patients with PD have long been shown to have elevated levels of iron in the brain, compared to those without the incurable, progressive neurodegenerative disorder which affects 1.5 million people in this country. The symptoms of PD include tremor, slowness of movement, rigidity and problems with balance. Epidemiologic studies suggest that there is not a clear correlation between dietary iron intake in adults and the incidence of PD. The question remains, how does the iron get into the brain? Research led by Buck Institute faculty member Julie Andersen, PhD, suggests that the iron can collect in the brain during the first two years of life, before the human blood/brain barrier is fully closed.

The research involved delivering iron orally to mouse pups on a daily basis starting at ten days of age for one week. That time period is equivalent to the first year of human life; the dosage was equivalent to the amount of iron in fortified infant formula. The mice were then allowed to age normally to two, 12, 16 and 24 months of age. Iron levels were measured in the substantia nigra (SN), an area of the brain where dopamine, the neurotransmitter associated with Parkinson’s disease, is made. Excess iron is believed to cause oxidative stress which eventually destroys the neurons which produce dopamine.

Iron levels in the iron-fed pups were found to be significantly increased in the SN by two months of age; by 12 months of age (the human equivalent of middle-age) the mice began to show signs of SN neurodegeneration. Within 16 -24 months (60 to 80 years of age in humans) the mice showed an actual loss of dopamine-producing neu rons. All of the mice, bred from the same genetic strain, showed signs of damage.

‘We recognize that this work is in mice, not humans,’ said Andersen, ‘We’re not saying not to supplement infant formula with iron, but perhaps the levels need to be adjusted.’ Human infant formula, which is regulated by the FDA, is supplemented with iron to prevent iron-deficiency anemia, which can lead to mental retardation. Although iron supplementation in humans shows no discernable adverse effects up to six years of age, its affects later in life have yet to be assessed, according to the American Academy of Pediatrics.

‘We really have very few models to study early exposure to toxins as a risk factor for a late-life disease such as PD,’ said J. William Langston, MD, CEO and Scientific Director of the Parkinson’s Institute. ‘We haven’t had good proof of principle; Julie’s work really is one of the few examples where that seems to be the case in an experimental model. Early life exposure to iron does seem to set up a sequence of processes that leads to cell damage in the substania nigra later in life.’ Langston added, ‘That’s a really important principle known as ‘long-latency neurotoxicity’ that scientists have been trying to prove for many, many years. Her work could be groundbreaking, moving this field forward. And of course this research has obvious public health implications.’

Studies involving the mice continue in the Andersen lab; efforts are aimed at determining whether the oxidative damage is reversible, and at what point that could be accomplished. Once the blood/brain barrier is closed, the iron cannot be removed from the brain. An earlier study by Andersen showed that ‘tying up’ excess iron in mice by using a metal chelator (derived from the Greek word for claw) prevented damage to the dopamine-producing neurons of the SN.

‘Extensive elimination of iron from the brain is not desirable,’ said Andersen. ‘It is an essential trace metal needed for many biological reactions including the synthesis and release of neurotransmitters. However, we think the results of this study warrant further epidemiological studies in humans, especially as it impacts on neurological function in older individuals.’ Andersen added, ‘It would also be interesting to assess the value of iron chelation as a possible therapeutic in regards to the progression of age-related neurodegeneration as a consequence of high iron intake in infants.’

Joining Andersen in the study include Deepinder Kaur, lead author on the publication as well as Subramanian Ragajolan and Shankar Chinta from the Buck Institute and Dino Dimonte at the Parkinson’s Institute in Sunnyvale, California. This work was funded as part of a collaborative center grant on the role of the environment in Parkinson’s disease funded by the National Institute of Environmental Health (NIEH).

The Buck Institute is the only freestanding institute in the United States that is devoted solely to basic research on aging and age-associated disease. The Institute is an independent nonprofit organization dedicated to extending the healthspan, the healthy years of each individual’s life. The National Institute of Aging designated the Buck a ‘Nathan Shock Center of Excellence in the Biology of Aging,’ one of just five centers in the country. Buck Institute scientists work in an innovative, interdisciplinary setting to understand the mechanisms of aging and to discover new ways of detecting, preventing and treating conditions such as Alzheimer’s and Parkinson’s disease, cancer and stroke. Collaborative research at the Institute is supported by new developments in genomics, proteomics and bioinformatics technlogy.

Source: Newswise
'"/>




Related medicine news :

1. Infant receives first bloodless liver transplant
2. Smoking Linked To Low Infant Birth Weight
3. Banning Smoking in the Home Helps Infants
4. Benefits of Nitric Oxide in the Treatment of Premature Infants
5. New Technique to Study Infants Brain.
6. Infant Fevers Found to Reduce Allergy Risk Later In Life
7. Limiting Infants Exposure To Smoke At Home
8. fMRI Offers Insight Into An Infants Brain
9. Drug Used To Improve Lung Function In Infants Could Slow Down Motor Coordination
10. Infants going to day-care may have lower risk of leukemia
11. Infants at lower risk from digestive disease if introduced to cereal early
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2016)... ... 05, 2016 , ... US Sports Camps , official operators of Nike ... high-performance kids yoga training. ChildLight Yoga Studio is centrally situated in the picturesque New ... ChildLight Yoga Studio founder Lisa Flynn expresses her excitement, “We are thrilled to be ...
(Date:2/5/2016)... ... , ... Give To Cure today announced that it is working ... To Cure’s campaign that is crowdfunding clinical trials to help find cures faster for ... a smart device. In 2015 alone, Venmo processed $7.5 billion in transactions among users. ...
(Date:2/5/2016)... ... ... Dr. Justin Scott and Dr. Lydia Muccioli of Pure Dental Health ... in need. The event is scheduled to take place on February 27, 2016 from ... dental care to community members in need. Each patient will be given the opportunity ...
(Date:2/5/2016)... ... February 05, 2016 , ... In sleep, when the defenses of ... A hallmark feature of patients with eating disorders is significant self-criticism, and consequently these ... and obsessions are regarded as maladaptive means for coping with this unease, but also ...
(Date:2/5/2016)... , ... February 05, 2016 , ... Calls Blacklist has ... completely new user interface design and the developer has fixed known bugs within the ... want to on their phone while not consuming any of their device’s battery power ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... N.Y. , Feb. 5, 2016  Henry Schein, ... health care products and services to office-based dental, animal ... entered into an agreement to acquire a majority ownership ... supplies and equipment in Brazil . ... Headquartered in Blumenau, Brazil, Dental Cremer is the dental distribution ...
(Date:2/4/2016)... For hospitals considering enrollment in the Federal ... the program, the Health Resources and Services Administration,s (HRSA) ... Mega-Guidance , could have significant impact on plans and ... 2016. Essential Insights , Daniel Neal, ... the Mega-Guidance,s key proposed changes, including a new requirement ...
(Date:2/4/2016)... 4, 2016   Bernstein Liebhard LLP today announced ... United States District Court for the District of ... consisting of all persons or entities who purchased common shares ... INSY ) from March 3, 2015 through January 25, 2016 ... its officers with violations of the Securities Exchange Act of ...
Breaking Medicine Technology: