Navigation Links
Indian Scientists Identify Second Pancreatitis Gene

Indian scientists have discovered a second candidate gene - cathepsin B - responsible for the fatal tropical calcific pancreatitis disease that leads to a gradual destruction of the pancreas.//

A chronic disease that leads to progressive destruction of pancreas and a painful death, pancreatitis can strike people in tropical countries, including India, and in the west.

The gene was identified by experts of two premier Hyderabad-based scientific institutions - the Centre for Cellular and Molecular Biology (CCMB) and the Asian Institute of Gastroenterology (AIG).

CCMB chief G.R. Chandak and D. Nageshwar Reddy of AIG told reporters in Hyderabad Friday that their extensive study found two different genes that caused pancreatitis.

Since the experts started collaborative research on the subject, this is the second candidate gene they have found responsible for causing the chronic pancreatitis.

Earlier, they had identified the involvement of the mutation of another gene - SPINK1.

"SPINK1 produces protein trypsin, which normally works as an inhibitor inside the pancreas. But mutation in SPINK1 gene can reduce the inhibitory function of trypsin, which becomes active inside pancreas and starts digesting the pancreas itself," Chandak said.

However, they found that the mutation of SPINK1 gene was not present in all patients of chronic pancreatitis and it raised the possibility of other genes also causing the same disease. Further research led to the discovery of another gene - cathepsin B - that causes the same disease.

According to the study, which was carried by international medical journal GUT in its online edition, the mutation of cathepsin B works like a trigger for trypsinogen to become active prematurely inside the pancreas and thus damage the pancreas.

Chandak said that even though these two genes work from different pathways, the next task before his team was to find whether there was any link between the two and its role.

In case of pancreatitis in the west, the disease is caused by the mutation of another gene - cationic trypsinogen - and this mutation is not found among the populations of tropical countries.

"This underlines the need for conducting separate research on the genetic basis of different diseases that are typical to our countries," Reddy said.

The study covered 306 patients and 330 healthy people, almost half of them from the state of Kerala, where the disease is reportedly rampant.

CCMB director Lalji Singh described the development as immensely significant. He said: "No one in the past had found the mutation of this gene. This is the first time in the world that it has been identified".

"If we put together SPINK1, the first mutation gene and the second mutation gene, it will be possible in the future to predict via screening a newborn baby's propensity for pancreatitis.

"On the basis of the prediction, a clinic can counsel on diet and lifestyles. It will be even possible to prevent the disease," he said.

Pancreas, the second most important organ in the human body after the heart, plays a major role in digestion of food and regulation of blood glucose mechanism in the body.

"Whenever pancreas becomes abnormal or develop chronic pacnreatitis, then the patient will develop diabetes mellitus because the glucose cannot be properly regulated and insulin is not secreted. Further degeneration leads to cancer of pancreas and it proves fatal," said Reddy.

The disease is also one of the major contributing factors in causing diabetes, the incidence of which is very high among Indians.

Edited IANS
'"/>




Related medicine news :

1. Indian Prime Minister has successful Knee Replacement Surgery
2. Development of AIDS vaccine -- Chiron Corp in talks with four Indian cos
3. Indian Doctor granted US patent on organ regeneration
4. Heart attack kills one in every 10 Indians
5. Indian Cherry: Richest Source of Vitiamin C
6. Indian Nationals with Foreign Medical Degrees can now practice in India
7. An Indian Bride with signs of SARS
8. Are Indians aware of SARS ?
9. Indians Stay Away from Coke, Pepsi After Toxin Scare
10. Indian pharma industry upbeat on WTO drug deal
11. Indian Treatment for Iraqi Babies
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ... that offers insurance and financial preparation services, is providing an update on a ... organization. , Rock City Rescue is a locally recognized nonprofit that provides shelter ...
(Date:10/13/2017)... ... October 13, 2017 , ... The International Association of Eating ... excellence for the field of eating disorders, announces the opening of early registration ... Orlando, Florida at the Omni Resort at ChampionsGate. , The annual ...
(Date:10/13/2017)... ... 2017 , ... Apple Rehab Shelton Lakes , which specializes in the ... facility as part of a disaster drill on October 3rd. , Apple Rehab participated ... Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid Plan ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the ... save lost souls in the Philippines. “The Journey: From the Mountains to the Mission ... of the Bible. She has taught all ages and currently teaches a class of ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... South Korea , Oct. 4, 2017  South ... its next-generation CPR training aide "cprCUBE" on Kickstarter. The ... chest compression during cardiac arrests with better efficiency compared ... It also offers real-time feedback on efficacy of the ... The crowdfunding campaign has a goal to raise $5,000. ...
(Date:10/2/2017)... -- Eli Lilly and Company (NYSE: LLY ) ... of 2017 on Tuesday, October 24, 2017. Lilly will ... the investment community and media to further detail the ... begin at 9 a.m. Eastern time. Investors, media and ... the conference call through a link that will be ...
(Date:9/28/2017)... -- Hill-Rom Holdings, Inc. (NYSE: HRC), will host its ... on Friday, November 3, 2017, beginning at 7:00 a.m. ... 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... and guidance for 2018, Hill-Rom executives will also highlight ... and long-range financial outlook through 2020. ...
Breaking Medicine Technology: