Navigation Links
Increase Testosterone Levels To Slow Down Alzheimer’

Administering Testosterones can slow down the progression of Alzheimer's disease (AD) according to a study conducted on mice. Testosterone, the primary male sex hormone, is one// in a group of related steroid hormones referred to as androgens.

The findings, published in the December 20 issue of The Journal of Neuroscience, provide new insight into the relationship between testosterone loss and AD, which affects 4.5 million Americans.

Senior author Christian Pike, PhD, of the University of Southern California (USC), with colleagues at USC and the University of California, Irvine, sought to better understand the role hormones play in aging and disease. Recent studies had already established a link between testosterone loss in men and AD due to natural aging.

The research team established a correlation between low testosterone and elevated beta-amyloid (Aa), a protein that accumulates abnormally in AD patients. This finding, they say, suggests that testosterone depletion in aging men may be a risk factor for AD by promoting accumulation of Aa in the brain. Recent studies suggest that androgens may lower Aa levels.

"This study raises the possibility that androgen replacement therapy might lower the risk for Alzheimer's, but this is far from proven," says Sam Gandy, MD, PhD, chair of the Alzheimer's Association's Medical and Scientific Advisory Council and director of the Farber Institute for Neurosciences at Thomas Jefferson University. "Because testosterone is rapidly converted to estrogen after entry into neurons, the new data are logical, and they dovetail well with historical data."

Using a mouse model of AD, in which three genes had been altered, researchers evaluated how experimental manipulation of sex hormones affected the progress of the disease. Researchers removed the testes of young adult male mice and over several months, treated some with a testosterone hormone and others with a placebo.

After the treatment period, memory-related behavior and measures of Alzheimer-like pathology were measured in the different groups of mice. The castrated models that received the placebo showed poor working memory and high brain levels of Aa. However, both Aa accumulation and cognitive decline were prevented in mice treated with the hormone therapy.

"Although the results of the study predict that androgen therapy has the potential to reduce the risk of AD in at least some men," Pike said, "clinical studies will be required to determine when and how to use androgen therapy."


Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Increase in sugar...decrease in brain function!!!
3. Increase in tobacco deaths
4. Increased Heart Attack Risk From Celebrex,Vioxx
5. Deep Sleep Doesnt Increase Memory
6. Allergy Risk Increased by Kerosene Use
7. IVF technique May Increase The Risk Of Birth Defects
8. Step Aerobics Increases good cholesterol
9. Increase in renal problems
10. Fewer teeth & Increased Ischemic Stroke risk
11. Painkillers Increase Risk of Miscarriage
Post Your Comments:

(Date:6/27/2016)... , ... June 27, 2016 , ... ... mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... to the network of the Tennessee Counseling Association, adding exclusive benefits and promotional ...
(Date:6/27/2016)... ... June 27, 2016 , ... recently awarded their highest five-star rating to ... of individuals in the United States and Canada wear eyeglasses. Once considered to be ... vision and make a fashion statement. Even celebrities use glasses as a way of ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ... , "Film editors can give their videos a whole new perspective by using the ... CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research and Markets ... for Companion Diagnostic Tests" report to their offering. ... Companion Diagnostics The World Market for Companion ... medicine diagnostics. Market analysis in the report includes the following: ... (In Vitro Diagnostic Kits) by Region (N. America, EU, ROW), ...
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
(Date:6/24/2016)... 2016  Arkis BioSciences, a leading innovator in ... durable cerebrospinal fluid treatments, today announced it has ... is led by Innova Memphis, followed by Angel ... investors.  Arkis, new financing will accelerate the commercialization ... release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: