Navigation Links
Inaccuracies in Cardiac PET-CT Scanning

Current PET-CT scanners with standard commercial software designed to provide images of the heart are falsely indicating coronary artery disease in as many as 40 percent of patients .

Lead author K. Lance Gould, M.D., professor in the Division of Cardiology at The University of Texas Medical School at Houston, said he discovered the abnormalities upon his initial use of cardiac PET-CT scanners in the Weatherhead P.E.T. Center For Preventing and Reversing Atherosclerosis at Memorial Hermann-Texas Medical Center.

Positron emission tomography, or PET, is nuclear cardiac imaging for optimally assessing blood flow in the heart. When paired with CT, or computed tomography, the PET-CT scanners should be an accurate, noninvasive tool for detecting or assessing severity of heart disease, said Gould, executive director of the Weatherhead P.E.T. Center. However, he said, an erroneous basic concept in the software functions make the PET-CT scanners prone to generating false-positive results.

The technology showed false-positive results in 40 percent of the 259 patients who participated in Goulds study. In 23 percent of those patients, it showed severe false abnormalities suggesting heart disease, which Gould said could have resulted in unwarranted, emergency heart procedures if he had not run additional tests to confirm his suspicions of the inaccurate results.

We found errors that are inherent in the technology as now used. Failure of physicians to recognize and correct those errors can have a profound impact on patients lives, said Gould, the Martin Bucksbaum Distinguished University Chair. These falsely positive results could lead to unnecessary procedures for nonexistent heart problems or for problems that could be treated without surgery.

The commercial software does not account for movement in the lungs and heart while the patient is breathing during the test, Gould said, and as a result, the PET and CT im ages dont always match or co-register. Consequently, the images have big holes or gaps where the processing is incorrect in areas where the PET and CT data fail to match, Gould said. It looks like someone has severe disease.

On discovering the problems, Gould developed a solution with Tinsu Pan, Ph.D., associate professor in the Department of Imaging Physics at The University of Texas M. D. Anderson Cancer Center, by rewriting the software to account for breathing motions and correctly aligning PET and CT images.

When done properly, PET-CT produces absolutely perfect images of blood flow in the heart muscle, he said. Its the best way to assess and direct management of heart disease. Unfortunately, according to Gould, the redesigned software is not generally commercially available at this time.

Gould also says, This medical product is out there on the market, and physicians and their patients trust it, yet there is a big problem with it. Since PET-CT proved ideal for cancer, body and brain imaging, everyone assumed its application to the heart would work with the same protocols and software a big mistake.

Gould, a preventive cardiologist, has been using traditional PET imaging throughout his medical career to detect heart disease, to determine the need for arteriograms, stents or bypass surgery and to monitor the reversal of the disease in his patients who follow his program of diet, exercise and medication. Adding the CT component to PET is a faster way to produce cardiac images and obtain additional information about coronary calcium deposits due to atherosclerosis.

Properly co-registered PET/CT data provide definitive perfusion images demonstrated in this study and, as reported earlier, suitable for assessing severity of coronary artery disease, for following its regression or progression, and for identifying mild early non-obstructive coronary atherosclerosis as the basis for intense, lifelong pharmacologic and lifestyle management, the publication states.

PET-CT is a valuable tool in the detection and management of coronary artery disease, Gould said, and he hopes other cardiologists and their patients will insist that scanner manufacturers resolve problems with the software to produce the most accurate results.

For patients who have recently had a PET-CT and been diagnosed with coronary artery disease, Gould recommends they seek a second opinion and request review of their PET-CT scans for these errors in matching the PET and CT images.

Alternatively, traditional or pure PET without the CT component is less subject to this problem. However, Gould cautioned: Alternative non-invasive technologies such standard SPECT nuclear cardiac imaging and CT angiography have been proven to have comparable false positive results for different reasons.

Pure PET or PET-CT done properly are the best non-invasive tests for early coronary heart disease or for assessing its severity but have to be done correctly with attention to technical details.

For more information on the study, visit http: jnm.snmjournals.org


'"/>




Related medicine news :

1. Cardiac diseases develop early
2. Heart problems detected better with a Cardiac MRI
3. Cardiac events better treated with intense cholesterol-lowering regime
4. Sudden Cardiac Death due to inherited Heart Disease
5. Vasopressin Found To Boost Survival In Sudden Cardiac arrest
6. Stem Cells From Bone Marrow Found To Improve Cardiac Functioning After A Heart Attack
7. Cardiac – Rehabilitation Programs Beneficial for Heart Patient
8. Cardiac Valve Disease Linked To Genes
9. Stanford Medical Center Implements The First Virtual Cardiac Ultrasound
10. Prevent Cardiac Problems And Laugh Your Way To Good Health
11. Higher Statin Dose Safely Reduces Stroke and Cardiac Arrest
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/9/2016)... ... December 09, 2016 , ... The Pennsylvania Athletic Trainers’ ... during the summer of 2016. The program was made possible by a Pennsylvania ... Department of Health and Human Services Administration. The broadcast, Use Your Head: ...
(Date:12/8/2016)... ... December 08, 2016 , ... Russ DiGilio ... the first national #QuackGivesBack campaign which supported local breast cancer organizations during National ... Quack Gives Back initiative, and we’re very pleased with the participation ...
(Date:12/8/2016)... ... December 08, 2016 , ... CURE Media Group, the ... advocacy groups, has aligned with Upstage Lung Cancer in efforts to combat lung cancer, ... Michael J. Hennessy, Jr said, “CURE Media Group is honored to team up with ...
(Date:12/8/2016)... Fla (PRWEB) , ... December 08, 2016 , ... ... smarter modes of access for customers and employees that are both engaging and ... 7 with Service Smart Technology, the software company revealed today its plans to ...
(Date:12/8/2016)... ... December 08, 2016 , ... STAT courier is pleased to announce ... service for Texas, they are expanding their presence in Dallas. One of the most ... will bring new jobs to the Dallas and Forth Worth market. STAT takes pride ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 2016 Australia Glaucoma Surgery Devices Market ... report, "Australia Glaucoma Surgery Devices Market Outlook to ... Glaucoma Surgery Devices market. The report provides value, ... and average prices (USD) within market segement - ... company shares and distribution shares data for each ...
(Date:12/8/2016)... 8, 2016 Global Interventional Radiology Market: ... global interventional radiology market analyzes the current and ... an elaborate executive summary, including a market snapshot ... sub-segments. The research is a combination of ... bulk of our research efforts along with information ...
(Date:12/8/2016)... 8, 2016  Diplomat Pharmacy, Inc. (NYSE: DPLO) has been recognized ... Top Workplaces National Standard. To learn more about ... ... Inc.) ... survey administered by WorkplaceDynamics, LLC, a research firm specializing in organizational ...
Breaking Medicine Technology: