Navigation Links
Implications of Statin Therapy in Bladder Cancer Patients

Smoking is one of the major risk factors for the development of bladder cancer and is also associated with cardiac disease, hyperlipidemia, and atherosclerosis.//

Consequently, it is not uncommon for patients with bladder cancer to have concomitant cardiac disease and hyperlipidemia. The 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are widely used in the treatment of hyperlipidemia and, in fact are available as over the counter drugs in some countries due to a perceived significant impact on overall mortality from cardiac disease.

In the January issue of the New England Journal of Medicine, Hoffmann and colleagues reported on a series of patients with bladder cancer who were treated with BCG. Of the 84 patients, 19 were also receiving statin therapy. After a median follow-up of 46 months, it appeared that patients receiving statin therapy had a higher incidence of disease progression (10 of 19 (53%) versus 12 of 65 (18%), p = 0.004). The number of recurrences did not differ significantly between the groups. While a larger number of patients on statin therapy underwent radical cystectomy, among the patients who underwent radical cystectomy, the number in whom metastases developed and the time to their development were similar in the two groups. The authors concluded that 'Our observations suggest that the discontinuation of statin therapy during BCG immunotherapy might improve the clinical outcome'.

In the March issue of NEJM, Kamat and Wu reported on the outcomes of a cohort of 156 patients who received BCG treatment; 39 took statins during BCG, and 117 did not. After a median follow-up: 56 months, there was no difference in recurrences (59% in both groups, p = 0.801), tumor progression (30% vs. 28%, p = 0.57) or deaths. Furthermore, there was no difference in outcomes, even when accounting for whether patients received only induction BCG therapy or induction BCG plus maintenance therapy.

At the current time, treating urologists and patients should view the available data as inconclusive, at best. This is especially important since patients with bladder cancer commonly use statins, and some reports have documented antiproliferative effects of statins urothelial cancer cell lines. Further more, since it has been shown that discontinuation of statin therapy can have adverse cadiac outcomes, it seems prudent to continue statin therapy in bladder cancer patients who are on BCG, until more robust data to suggest otherwise are presented.

Source-Newswise
'"/>




Related medicine news :

1. Genetic Eye Disorder Can Have Other Implications
2. New Way to Open Cellular Ion Channels, Implications for Drug Design
3. Statins reduce heart attacks
4. Statins reduce risks for angioplasty patients
5. Statins Found To Be Helpful For Patients With Arthritis
6. Long-Term Benefits Of Statins Questioned
7. Higher Statin Dose Safely Reduces Stroke and Cardiac Arrest
8. Use of Statin can help in recovery from stroke
9. Statins Not Effective In Treating Calcific Aortic Stenosis
10. Statins Gives New Hope for Increased Survival Rate of Heart Failure Patients
11. The Effects of Statins Questioned
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... N.Y (PRWEB) , ... October 13, 2017 , ... Lori ... became a member of ElderCounsel, a national organization of elder law and special needs ... changing laws and rules. It also provides a forum to network with elder law ...
(Date:10/13/2017)... ... 2017 , ... Ellevate Network, the leading network for professional women, brought together ... equality at their inaugural Summit in New York City in June. The event was ... of over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... and Agile Software Development, has been awarded a contract by the Center for ... Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in a ...
(Date:10/12/2017)... Francisco, CA (PRWEB) , ... October 12, 2017 ... ... Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus O2Vent ... apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral appliances ...
(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris ... of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking ... in the field of medical informatics, this prestigious award is presented to an individual ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... 25, 2017   Montrium , an industry ... today—from the IQPC Trial Master Files & Inspection ... that EastHORN Clinical Services has selected eTMF ... TMF management. EastHORN, a leading European contract research ... increase transparency to enable greater collaboration with sponsors, ...
(Date:9/23/2017)... -- Janssen Biotech, Inc. (Janssen) announced today that it ... Food and Drug Administration (FDA) for the Biologics License ... of moderately to severely active rheumatoid arthritis (RA). The ... to further evaluate the safety of sirukumab in the ... "We are disappointed by ...
(Date:9/22/2017)... , Sept. 22, 2017 AVACEN Medical ... device is now successfully helping those with the widespread ... Fibromyalgia diagnosed Amanda in Essex, England ... and washing my hair, experiencing no sleep at all, ... painful spasm… I cannot recommend [the AVACEN 100] enough, ...
Breaking Medicine Technology: