Navigation Links
Immunotherapy Does Not Prolong Life When Skin Cancer Spreads

The addition of immunotherapy to chemotherapy for malignant skin cancer that has spread does not improve survival rates, researchers have found, and patients have more serious side effects, such as anemia, when the two treatments are combined. //

Malignant melanoma develops when cancer grows in the cells responsible for skin color, and is one of the most aggressive forms of skin cancer. Having unusual moles, exposure to sunlight and being fair-skinned are thought to place people at higher risk.

The use of oral or injected chemotherapy drugs to kill melanoma cancer cells can be effective if the cancer is diagnosed early, but once it has spread — metastasized — it is almost always fatal.

According to the National Cancer Institute, each year about 53,600 people in the United States are diagnosed with melanoma and 7,400 die from it. The incidence of melanoma has risen an alarming 3 percent a year since 1981, according to the Centers for Disease Control and Prevention.

Researchers have hoped that a combination of immunotherapy — treatment that bolsters or stimulates patients’ immune systems — and chemotherapy might be an option for people with malignant melanoma.

Authors led by Andre Sasse, M.D., at the research center Onco-Evidencias in Sao Paolo, Brazil, reviewed 18 studies of 2,625 patients who were treated with either chemotherapy alone or a combination of chemo- and immunotherapy.

“No difference was seen in survival rate and toxic effects were increased” when immunotherapy was added to chemotherapy, the researchers write.

The review appears in the current issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing medical trials on a topic.

The review examined two kin ds of immunotherapy combined with chemotherapy, interferon and interleukin-2. Of the 11 studies that reported on side effects from chemoimmunotherapy, eight showed blood disorders and flu-like symptoms resulting from the combined treatment. In four studies that used interleukin-2 without interferon, patients had more blood side effects after treatment.

Jedd Wolchok, M.D., an oncologist at Memorial Sloan-Kettering Cancer Center, said that it is difficult to tease out which of the two immunotherapy agents might be responsible for the side effects to patients’ blood.

“Both immunotherapies have considerable side effects,” Wolchok said. “Interleukin-2 is likely more difficult since it can lower blood pressure and cause fluid to build up in the body. These side effects are a consequence of what these immune hormones were originally designed to do — for example, interferon is a natural antiviral agent, so the fact that it causes flu-like symptoms very commonly is not a surprise.”

Sasse said, “The interleukin is more toxic and needs hospitalization for its administration. It is also known to promote more systemic reactions than interferon. But the adverse effects of either drug are dose dependent.”

Wolchok said, “This area should definitely continue to be investigated. My hypothesis is that chemotherapy may be used to modulate and potentiate newer immunotherapy drugs.”

Sasse, however, said, “There are some controversies about the use of chemotherapy in advanced melanoma — the chemotherapy does not save lives and additionally, there is doubt that it prolongs the survival of these patients.”

“My opinion is that there are enough studies in this subject and therefore, no need of new trials,” Sasse added. “At the moment, the focus should be given to the development of new therapeutic approaches to melanoma.” He cited advances in molecular biology and the carcinogenesis of melanoma as possible avenues for ne w treatment in the future.
SRM
'"/>




Related medicine news :

1. Immunotherapy For Cancer Treatment
2. Passive Immunotherapy Could Prevent Avian Flu from Affecting Humans
3. Immunotherapy Does Not Prolong Life When Skin Cancer Spreads
4. Prolonged survival not assured by psychological therapies for cancer patients
5. Better Diet Even Late in Life May Prolong It
6. Novel Treatment Found To Prolong Survival Of Liver Cancer Patients
7. Prolonged Use Of Contraceptive Pill Dianette May Cause Depression
8. Woman Elects For Mastectomy: Prolonged Wait For Genetic Results
9. Effect of Prolonged Stay in Space Studied Using Fruit Flies
10. Physical Activity of any kind to Prolong Life
11. AIDS Sufferers Turn to British Doctor to Prolong their Survival
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/27/2017)... ... July 27, 2017 , ... Trusted dentist, speaker and ... sleep apnea in Wayne, NJ to receive custom treatment at his practice ... apnea with the use of custom-crafted oral appliances. Highly-trained in using the latest ...
(Date:7/27/2017)... Viejo, CA (PRWEB) , ... July 27, 2017 , ... ... Cut Pro X . This Final Cut Pro X exclusive features transitions that contain ... and add rotation to the transition using intuitive drop-down menus. TransPanel Volume 4 makes ...
(Date:7/27/2017)... ... 2017 , ... SSCI, a division of Albany Molecular Research, ... representing a milestone achievement. , As an industry-leading provider of ... served as expert and fact witnesses to assist our clients to perform infringement ...
(Date:7/27/2017)... ... July 27, 2017 , ... MAP Health Management, ... year’s Fierce Innovation Awards: Healthcare Edition 2017, an awards program from the publisher ... Population Health Management/Patient Engagement Solutions. , MAP was selected as a finalist ...
(Date:7/27/2017)... ... July 27, 2017 , ... ... 2012-2016, will keynote Day 2 of the HIMSS Healthcare Security Forum, the nation’s ... the Sheraton Boston Hotel, Sept. 11-13, 2017. , Daniel will deliver his keynote, ...
Breaking Medicine News(10 mins):
(Date:7/26/2017)... Sancilio Pharmaceuticals Company, Inc. (SPCI) today announced ... Altemia TM , an oral therapy for pediatric patients ... (SCD). The SCOT Trial, is a double-blind, placebo-controlled, dose-finding, ... Altemia TM in pediatric patients aged 5-17 years ... "The completion of ...
(Date:7/24/2017)... IBM (NYSE: IBM ) has been recognized ... Arrays (SSA) for the fourth year in a row. 1 ... "Vendors in the Leaders quadrant have the highest scores for ... in the Leaders quadrant has the market share, credibility, and ... new technologies. These vendors demonstrate a clear understanding of market ...
(Date:7/21/2017)... 21, 2017  Endo International plc (NASDAQ: ... review of its manufacturing network, the Company will be ... in Huntsville, Alabama . The closure ... the next 12 to 18 months. The ... volumes of commoditized products and these restructuring actions are ...
Breaking Medicine Technology: