The addition of immunotherapy to chemotherapy for malignant skin cancer that has spread does not improve survival rates, researchers have found, and patients have more serious side effects, such as anemia, when the two treatments are combined. //
Malignant melanoma develops when cancer grows in the cells responsible for skin color, and is one of the most aggressive forms of skin cancer. Having unusual moles, exposure to sunlight and being fair-skinned are thought to place people at higher risk.
The use of oral or injected chemotherapy drugs to kill melanoma cancer cells can be effective if the cancer is diagnosed early, but once it has spread — metastasized — it is almost always fatal.
According to the National Cancer Institute, each year about 53,600 people in the United States are diagnosed with melanoma and 7,400 die from it. The incidence of melanoma has risen an alarming 3 percent a year since 1981, according to the Centers for Disease Control and Prevention.
Researchers have hoped that a combination of immunotherapy — treatment that bolsters or stimulates patients’ immune systems — and chemotherapy might be an option for people with malignant melanoma.
Authors led by Andre Sasse, M.D., at the research center Onco-Evidencias in Sao Paolo, Brazil, reviewed 18 studies of 2,625 patients who were treated with either chemotherapy alone or a combination of chemo- and immunotherapy.
“No difference was seen in survival rate and toxic effects were increased” when immunotherapy was added to chemotherapy, the researchers write.
The review appears in the current issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing medical trials on a topic.
The review examined two kinPage: 1 2 3 Related medicine news :1
. Immunotherapy For Cancer Treatment2
. Passive Immunotherapy Could Prevent Avian Flu from Affecting Humans3
. Immunotherapy Does Not Prolong Life When Skin Cancer Spreads4
. Prolonged survival not assured by psychological therapies for cancer patients5
. Better Diet Even Late in Life May Prolong It6
. Novel Treatment Found To Prolong Survival Of Liver Cancer Patients7
. Prolonged Use Of Contraceptive Pill Dianette May Cause Depression8
. Woman Elects For Mastectomy: Prolonged Wait For Genetic Results9
. Effect of Prolonged Stay in Space Studied Using Fruit Flies10
. Physical Activity of any kind to Prolong Life11
. AIDS Sufferers Turn to British Doctor to Prolong their Survival