Navigation Links
Immunosuppressive Action Of Fungal Metabolite - Gliotoxin

Researchers from Japan have recently demonstrated the first evidence that mast cell is a direct target of gliotoxin.

Fungal secondary metabolites such as gliotoxin, an epipolythiodioxopiperazine toxin produced by pathogenic fungi like Candida and Aspergillus//, possess immunosuppressive activities and have been thought to contribute to pathology of fungal infections in animals and humans.

Mast cells play a key role in host defense and are important both for innate and adaptive immunity, and so, these findings suggest that suppression of mast cell activation might contribute to the establishment of infections for the pathogenic gliotoxin-producing fungi. Since recent studies show that mast cell plays a crucial role in the front of host defense, researchers examined whether fungal secondary metabolites affected mast cell activation.

Their study findings appear in the journal Clinical Immunology (available online 6 October 2005) The researchers found that gliotoxin had suppressive effects on mast cell activation, including degranulation, leukotriene C4 secretion, and TNF-á and IL-13 production. Gliotoxin also suppressed intracellular Ca2+ rise through store-operated Ca2+ channels with a minimal effect on depletion of internal Ca2+ stores.

Finally, gliotoxin induced intracellular production of superoxide possibly through a thiol redox cycling, which appeared to mediate suppressive effects on mast cell activation.
'"/>




Page: 1

Related medicine news :

1. Immunosuppressive drug shows promise in treatment of eye disorder
2. A Newly Identified Immunosuppressive Protein in Rheumatoid Arthritis
3. Action of nerve cells
4. Herbs With Estrogen Action Aggravate Cancer Risk
5. Legal Action against Authority Regarding Outbreak of Legionnaires’ Diseas
6. Mode Of Action Of The Anti-Convulsant Valproate
7. Action Plan Against Drug Deaths Launched
8. Ramadoss to Take Severe Action against Fertility Clinics Conducting Stem Cell Therapy
9. UN Formulates Action Plan for Relief to Recovery in Quake-hit Areas of Pakistan
10. HIV Infected Body Parts Stolen: Biomedical Tissue Services To Face Legal Action
11. India to Implement National Action Plan against TB-HIV
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica ... Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs ... Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, ...
(Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... ... 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the ... to iHire in recognition of their exemplary accomplishments in worksite health promotion. , The ... Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association ... it will receive two significant new grants to support its work to advance ... 25th anniversary by recognizing patients, medical professionals and scientists for their work in ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
(Date:6/23/2016)... RIDGE, Ill. and INDIANAPOLIS ... of students receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship ... The 2016 scholarship winners, announced today online at ... to let type 1 diabetes stand in the way ... Diabetes has supported the Foundation,s scholarship program since 2012, ...
Breaking Medicine Technology: