Navigation Links
Immune Response Of Human Beings Can Be Re-energized

The immune response of human beings can be re-energized to counter chronic viral infection, according to a study which has been published in the journal Nature.// The research also provides a plan to improve T cell immunotherapy and therapeutic vaccines. The CD8 T cells of the immune system are subject to exhaustion while combating persistent viral infection, and become less effective over a period of time.

Researchers at Dana-Farber Cancer Institute and Emory University have traced the problem to a gene that turns off the infection-fighting drive of CD8 T cells in mice. The discovery raises the possibility that CD8 cell exhaustion can be reversed in human patients, reinvigorating the immune system's defenses against chronic viral infections ranging from hepatitis to HIV, the virus that causes AIDS.

"CD8 T cells that have fought viral infections retain a 'memory' of the viruses they've encountered, so they can rapidly respond to new infections from those viruses," said lead researcher Gordon Freeman.

In the case of chronic infection, however, senior author Rafi Ahmed has shown that memory cells become exhausted and lose the capacity to respond to the virus. To find the cause the researchers conducted a microarray experiment measuring the activity of thousands of genes in normal memory CD8 T cells in mice and in exhausted versions of those cells. They found that a gene known as PD-1 was much more active in the exhausted cells.

"When [co-author] John Wherry of the Wistar Institute found a high level of the PD-1 gene in microarray experiments, we wanted to test whether this was contributing to the CD8 exhaustion. We found that exhausted CD8 T cells in mice have unusually large numbers of PD-1 receptors, and blocking the PD-1/PD-L1 bond reactivated the cells' response to infection," said Freeman.

Just as strikingly, researchers found that even in persistently infected mice that lacked a type of T cell known as helper CD4, preventing PD-1 from binding to PD-L1 had a beneficial effect on "helpless" CD8 T cells -- restoring their ability to kill infected cells and release infection-fighting substances called cytokines, substantially reducing the animals' "viral load."

Edited (ANI)
'"/>




Related medicine news :

1. Immune cells halt round in space
2. Immune function could benefit from exercise
3. Reviving the Immune System
4. Wrestling found To Be Good for the Immune System
5. Immune Boost With LHRH To Help Cancer And Transplant Patients
6. Researchers Find Out The Cause Of Immune Attacks Behind Hearing Loss
7. Block Immune System Chemical For Treating Asthma
8. Weizmann Institute of Science says Immune Cells Could Help Maintain Brain Function
9. Antidepressant drugs interacts with Immune cells
10. Specific Immune Mechanism against DNA viruses
11. Immune response in Occupational metal fume inhaling workers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... one of the most popular and least understood books in the Holy Scriptures, Revelation. ... descriptions that have baffled scholars for centuries. Many have tossed it off as mere ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... services for healthcare compliance program management, will showcase a range of technology and ... for Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) ... FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... Morris F. Collen, a pioneer in the field of medical informatics, this prestigious award ...
(Date:10/12/2017)... ... ... Leading pediatric oncology experts at Children’s National Health System will ... the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by Jeffrey ... Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of the Division ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra Chief ... advancements to physician colleagues, skilled nursing facility medical directors and other clinicians at ... of Wound Care." , "At many of these conferences we get to educate ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017   Divoti USA ... Jewelry up to the standard of the latest FDA requirements, which ... 2017). Anyone in need of Medical ID jewelry such ... Alert Jewelry are engraved in terms of the new ... Divoti offers ...
(Date:10/11/2017)... Oct. 11, 2017  True Health, a leader ... its effort during National Breast Cancer Awareness month ... risks. Research ... calculated that more than 10 million American women ... in BRCA1 or BRCA2 and have not had testing. ...
(Date:10/7/2017)... 6, 2017   Provista, a proven leader ... billion in purchasing power, today announced a new resource ... The Newsroom is the online home for case ... expert bios, news releases, slideshows and events. ... wealth of resources at their fingertips, viewers can also ...
Breaking Medicine Technology: