Navigation Links
Immune Cells Destroy Bone In Gum Disease

Immune cells play a big role in the bone loss that results due to periodontal or gum disease, according to researchers at The Forsyth Institute. Earlier researchers had// speculated that the immune system was involved in destruction of bone in periodontal disease, but this is the first time it has been confirmed in human gum tissue. Forsyth researchers hope that the finding would help create new ways to stop bone loss in gum disease.

The study, led by Toshihisa Kawai, D.D.S., Ph.D., examined whether immune response to periodontal bacteria is protective or pathogenic in the context of gum disease. Periodontal disease is an infection of the teeth, and their supporting structures, which results in soft tissue and bone destruction, leading to tooth loss. Dr. Kawai and his colleagues had found that B cells (B and T lymphocytes are immune cells) can contribute to increased periodontal bone loss coordinating with activated T-cells. Both cell types had previously been found to manifest a host immune response to the bacteria causing bone loss in animal models, by his group.

"This research validates our hypothesis that immune cells are harmful in gum disease," said Dr. Kawai. "It's a groundbreaking discovery because it truly gives a new understanding of periodontal disease, while also raising interesting questions about immune cells. We hope this work will help us save people's teeth in the future."

Research Overview

RANKL is a protein that is a major factor in the regulation of osteoclasts (cells that destroy bone). Dr. Kawai's research examined the receptor activator of NF-kB ligand, (RANKL)-mediated osteoclastogeneis, and the pivotal role it plays in inflammatory bone resorption. The aim of this study, which will be published in the September issue of the American Journal of Pathology, was to identify the cellular source of RANKL in the bone resorptive lesions of periodontal disease. An active periodontal lesion is characterize
'"/>




Page: 1 2

Related medicine news :

1. Immune cells halt round in space
2. Immune function could benefit from exercise
3. Reviving the Immune System
4. Wrestling found To Be Good for the Immune System
5. Immune Boost With LHRH To Help Cancer And Transplant Patients
6. Researchers Find Out The Cause Of Immune Attacks Behind Hearing Loss
7. Block Immune System Chemical For Treating Asthma
8. Immune Response Of Human Beings Can Be Re-energized
9. Weizmann Institute of Science says Immune Cells Could Help Maintain Brain Function
10. Antidepressant drugs interacts with Immune cells
11. Specific Immune Mechanism against DNA viruses
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Immune Cells Destroy Bone Gum Disease

(Date:7/10/2014)... 10, 2014 (HealthDay News) -- Most professional football players ... to the game, a new study finds. Shoulder ... their rate of return after surgery to fix the ... The new study included 60 players who had shoulder ... procedure successfully returned to play, defined as playing in ...
(Date:7/10/2014)... HealthDay Reporter THURSDAY, July 10, 2014 ... out regularly between outspoken celebrities or loudmouth pundits -- too ... new study suggests. High amounts of Twitter use can ... is in a long-term relationship, according to findings from an ... friction can lead to cheating and breakups, the researchers concluded, ...
(Date:7/10/2014)... a microchip-based device developed at the Massachusetts General Hospital ... Cancer Center can be cultured to establish cell lines ... July 11 issue of Science , an MGH ... a tumor,s genetic mutation over time and changing susceptibility ... cells from the blood that represent those present in ...
(Date:7/10/2014)... EAST LANSING, Mich. For those students looking to ... answer may not be spending more time in a ... New Michigan State University research shows that students who ... on MSU,s campus during their freshman and sophomore years ... The research also indicated that students with memberships stayed ...
(Date:7/10/2014)... 2014) A research review identifying the clinical indicators ... step in the process of developing evidence-based guidelines for ... report published by Neurosurgery , official ... . The journal is published by Lippincott Williams ... Kluwer Health . , Based on analysis of ...
Breaking Medicine News(10 mins):Health News:Shoulder Surgery Gets NFL Players Back in the Game 2Health News:Are You Tweeting Your Marriage Away? 2Health News:Are You Tweeting Your Marriage Away? 3Health News:Cultured CTCs reveal genetic profile, potential drug susceptibility of breast cancer cells 2Health News:Cultured CTCs reveal genetic profile, potential drug susceptibility of breast cancer cells 3Health News:Want a higher GPA in college? Join a gym 2Health News:What's a concussion? Review identifies four evidence-based indicators 2Health News:What's a concussion? Review identifies four evidence-based indicators 3
... of Pennsylvania School of Medicine and Utrecht University has deciphered ... immune response. This system, called complement, comprises a network of ... invaders. It serves as a rapid defense mechanism in most ... published in the December 24 issue of Science , ...
... Reporter , MONDAY, Dec. 27 (HealthDay News) -- Marilyn Norred has ... "They saw them back then and said, ,Someday they,ll be ... in Oklahoma City, recalled. That time came this year. Norred ... right eye on May 27 and the left eye on June ...
... FRIDAY, Dec. 24 (HealthDay News) -- For years now, doctors ... a chronic autoimmune condition that can wrack the body and ... preparing for a potential major leap forward. A ... the disease was endorsed in mid-November by an advisory panel ...
... HealthDay Reporter , FRIDAY, Dec. 24 (HealthDay News) -- ... 1999. "I would wake up very stiff and achy," said ... a while to get going in the morning." Then, after ... woke up one morning and it was like I was paralyzed," ...
... Reporter , THURSDAY, Dec. 23 (HealthDay News) -- Cynthia Duggan ... needed dental braces that she hesitated to give her veterinarian ... procedure with her husband, the couple finally decided it would ... Duggan of the 9-month-old puppy, already showing potential as a ...
... , THURSDAY, Dec. 23 (HealthDay News) -- Hospital-wide patient death ... facility,s quality of care, a new study indicates. Researchers ... They found that the measures yielded both higher- and lower-than-expected ... The findings add to an ongoing debate about the ...
Cached Medicine News:Health News:Structure of key molecule in immune system provides clues for designing drugs 2Health News:Structure of key molecule in immune system provides clues for designing drugs 3Health News:Have Cataracts? Get Surgery, Woman Urges 2Health News:Lupus Treatment May Soon Take Leap Forward 2Health News:Lupus Treatment May Soon Take Leap Forward 3Health News:For California Woman, Lupus Is Life 2Health News:Doggy Dentistry Can Now Mean Braces 2Health News:Doggy Dentistry Can Now Mean Braces 3Health News:Better Methods Needed to Measure Hospital Quality: Experts 2
(Date:7/10/2014)... , July 10, 2014   LabStyle Innovations ... Solution, today announced the appointment of Professor ... of its Board of Directors. Prof. ... business experience to LabStyle as an entrepreneur, venture ... and corporate governance expert. He currently serves on ...
(Date:1/15/2014)... , Jan. 15, 2014 Most osteoporosis patients want ... a recent online survey* sponsored by Mission Pharmacal Company. ... National Osteoporosis Foundation online support community, revealed that 74 ... that comes in a form other than a pill ...
(Date:1/15/2014)... Jan. 15, 2014  Celsion Corporation (the "Company") (NASDAQ: ... from institutional investors to purchase an aggregate of approximately ... at-the-market registered direct offering, led by a dedicated health ... purchase agreements with these investors pursuant to which the ...
Breaking Medicine Technology:LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3
... --  Empire Genomics today announced that it has ... portfolio for the Japanese market.  The deal represents Empire,s international ... "We are excited to have such a proven and expert ... access to our broad genomic product and service portfolio," said ...
... MYL ) today announced that its subsidiary Mylan Pharmaceuticals Inc. ... Administration (FDA) for its Abbreviated New Drug Application (ANDA) for ... mg, 15 mg, and 20 mg. This product is the ... which is indicated for the treatment of schizophrenia and the ...
Cached Medicine Technology:Empire Genomics Chooses Funakoshi as Japan Distributor 2Mylan Launches Generic Version of Zyprexa® Tablets 2
... SPECIFICATIONS Form: Granular, free-flowing powder EEO (-m r ): ... less than or equal to 35C Remelt Point (3%): ... greater than or equal to 300 gm/cm 2 ... than or equal to 0.10% DNase: Passes test RNase: ...
... sulfate (SO 4 ) ≤ 1000 mg/kg Cation traces: ... ≤ 5 mg/kg Cr ≤ 5 mg/kg Cu ≤ ... mg/kg Mg ≤ 50 mg/kg Mn ≤ 5 mg/kg ... ≤ 5 mg/kg Zn ≤ 5 mg/kg Special grade: ...
... ≤ 500 mg/kg sulfate (SO 4 ) ≤ 1000 ... 5 mg/kg Co ≤ 5 mg/kg Cr ≤ 10 ... K ≤ 5 mg/kg Mg ≤ 5 mg/kg Mn ... 5 mg/kg Pb ≤ 5 mg/kg Zn ≤ 5 ...
Inquire...
Medicine Products: