Navigation Links
Identified Protein To Inhibit Cell Migration

Researchers from the University of North Carolina have identified a protein that may inhibit cellular movement, or migration. //

The protein, CIB1, or calcium and integrin-binding protein 1, was originally discovered at UNC in 1997 as a blood platelet protein that may play a role in clotting. Cell migration belongs to the most rudimentary of cellular functions that allow processes such as fetal development, new blood vessel formation and wound healing to occur in humans. Increased tumor cell migration also is one of the hallmarks of highly aggressive, rapidly spreading cancer tumors.

The study appears in the August issue of The Journal of Cell Biology.

The study indicates that CIB1 inhibits cell migration by binding to and activating a protein called PAK1, or p21-activated kinase, in cancer cells. When CIB1 activates PAK1, this kinase then inhibits cell migration by adding a phosphate group to a host of other proteins in the cell.

Thus, the study suggests that CIB1 may be a likely target for new drug development aimed at decreasing tumor metastasis, or spread, throughout the body.

CIB1 plays a prominent role in the activation of PAK1 and potentially may be another important player in the regulation of this kinase. The other activators of PAK1 include relatives of the notorious Ras family of tumor promoters, the GTPases Rac and Cdc42. CIB1 activation of PAK1, however, is different from these GTPases.

In illustrating the role that CIB1 plays in cell migration and PAK1 activation, the authors used a new method known as RNAi or RNA interference to knock down or reduce CIB1 expression in various cell lines. Cells with less CIB1 had less PAK1 activation and migrated faster. The authors also showed that the more CIB1 these cells had, the less likely they were to move.

Source: Newswise

Medindia on RNAi: Further information

RNAi: RNA in terference is a technique of gene silencing that is used to study the effect of absence of a gene, by causing disruption to its expression, on an animal or a plant.

'"/>




Related medicine news :

1. Potential New Cancer Gene Identified
2. Alcohol Dependence Gene Identified
3. More Causes of Bladder Cancer Identified
4. Dyslexia Gene Identified and Called "KIAA0319"
5. New Enzyme Identified For Arthritis
6. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
7. Toxin Identified For Alzheimer’s Diseas
8. Researchers Identified Process That Aids Spread Of Alzheimer’s’ Diseae
9. Gene Target For Tuberculosis Identified
10. Brain Chemical Identified For Drug Dependent Behavior
11. Molecule That Aids Bacterial Infections Identified
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/9/2016)... ... 09, 2016 , ... Dr. Rassouli, cosmetic dentist in Orange County , ... most popular cosmetic procedures in dentistry today, but the cost often leads to patients ... risk of teeth whitening-related damage. For a limited time, Dr. Rassouli is offering this ...
(Date:2/9/2016)... ... 2016 , ... United Methodist Communications collaborated with Chocolate Moose ... video designed to prevent the next widespread Ebola outbreak from occurring ... distributed throughout Togo, Liberia, Sierra Leone, Nigeria, Côte d’Ivoire and other African countries, ...
(Date:2/8/2016)... ... ... CURE Media Group , the nation’s leading digital and print media enterprise ... , which will annually honor individuals making heroic contributions in the field of multiple ... Awards nomination process is officially open through February 17 for patients, caregivers and ...
(Date:2/8/2016)... ... February 08, 2016 , ... The Valentine’s Season is famous for gift giving with flowers, ... that they are loved. This year, for more than 5.6 million Americans suffering with ... won't be enough to remind them of the lives they’ve led and the people they’ve ...
(Date:2/8/2016)... ... February 08, 2016 , ... Steve Helwig & Associates Insurance & Financial, serving ... program, has teamed up with Citizens Opposed to Domestic Abuse in support of its ... support all those victimized by the fear of violence in their own homes, donations ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... Inc. (NASDAQ: MSON ), an international surgical ... therapeutic ultrasonic products for spine surgery, skull-based surgery, ... other surgical applications, today announced financial results for ... fiscal year 2016 ended December 31, 2015. ... Highlights for the second quarter and first half ...
(Date:2/9/2016)... 2016 QGEN ; ... Abschluss eines Kooperationsvertrags mit 10x Genomics für ... den Bereichen Next-Generation-Sequencing (NGS), Single-Cell-Biology und Bioinformatik ... Prime Standard: QIA) gab heute den Abschluss ... Entwicklung und Förderung umfassender Lösungen in den ...
(Date:2/9/2016)... --  AllCare Plus Pharmacy announced today that it ... ® for Home Care Accreditation by ... Seal of Approval ® is a symbol of ... and effective care.  --> ... on-site survey in January 2016. The survey reflected compliance ...
Breaking Medicine Technology: