Navigation Links
Identification of gene

The mystery of what causes the fatal autoimmune disease Systemic Lupus Erythematosis has been solved by the identification of a possible genetic link.

Researchers at the University of California, San Diego School of Medicine (UCSD) uncovered the possible genetic link to SLE. Their report in a nationa journal say that a gene has been identified in mice which, if absent, causes symptoms remarkably similar to human SLE.//

SLE is an incurable and potentially fatal multi-organ disease that turns victims’ immune systems against them. The disease affects about one in 300 people, 90 per cent of them being women.It causes damage to kidneys, liver, brain, heart, spleen, joints, and lungs.

The investigators from UCSD,found that mice with a genetic mutation in an enzyme called alpha-mannosidase II develop lupus-type symptoms. This enzyme helps to form cell-surface carbohydrate structures called N-glycans, which enable the immune system to distinguish self from non-self.

In people with lupus and other autoimmune diseases such as arthritis, the body’s white blood cells, instead of destroying invading bacteria and viruses, attack normal organs. While these cells appear normal in lupus sufferers, the victims’ tissues and organs still appear ravaged by an attacking immune system.

Researchers had previously noticed that changes in N-glycans could lead to autoimmune disease. After pinpointing a gene which produces an enzyme that starts the glycan formation pathway, researchers bred mice without this gene. They found the gene-deficient mice had much lower levels of N-glycans, and abnormally shaped N-glycans molecules. At the same time, these mice had high levels of antibodies, kidney inflammation and other tissue damage.

Senior author of the study, Professor Jamey Marth said: "this is an entirely new manner by which autoimmune disease can occur, by a gene controlling carbohydrate formation. These findings provide new ins ights into understanding autoimmune disease and suggest new diagnostic tests for possible causes of human SLE ".


'"/>




Related medicine news :

1. New Gene Identification Help Asthma Treatments
2. The Use of Radio Frequency Identification ( RFID) to tackle the growing menace of counterfeit drugs
3. Protein Markers for Identification of Brain Tumor
4. Identification Of Gene Sequence To Promote Growth Of New Arteries
5. Colour Identification Lies Wholly On the Left Hemisphere of the Brain.
6. Novel Technique For Identification And Treatment Of Neurodegenerative Diseases
7. Combined Imaging Approach may Provide Better Identification of Difficult-to-diagnose Brain Clots
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2016)... ... February 08, 2016 , ... Discover the Rocky Mountain ... 1,400 booths and 700 companies. Attendees also get to see the most incredible ... Garden & Home Show , at the Colorado Convention Center - 700 14th St. ...
(Date:2/8/2016)... ... February 08, 2016 , ... Joshua Rosenthal, PhD, Chief Scientific ... can use newly released government data on populations and physicians to better calculate ... capture the value they create to succeed in new economic models for value ...
(Date:2/7/2016)... Michigan (PRWEB) , ... February 07, 2016 , ... ... organ prolapse with the latest techniques and the most minimally invasive approaches. , ... organ prolapse, particularly after menopause. Other risk factors include surgery to the pelvic ...
(Date:2/6/2016)... ... February 06, 2016 , ... ... NURSES EXPECTED AT AORN SURGICAL CONFERENCE & EXPO , WHAT:     , This ... an estimated 5000 perioperative nurses in attendance to study the latest evidence-based ...
(Date:2/6/2016)... ... February 06, 2016 , ... Research has shown that building ... the frequency and level of relapse. , At the 2016 iaedp ... will explore the critical tasks of the recovery phase and beyond including relapse ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... 8, 2016   GS1 US will hold ... them through GS1 Standards implementation to address the requirements ... Device Identification (UDI) rule. Scott Brown ... Gibson , senior director industry development, medical devices, GS1 ... GS1 US --> Scott Brown ...
(Date:2/8/2016)... Pa. , Feb. 8, 2016   ... November Research Group (NRG),s pharmacovigilance technology services ... system-related consulting services and an Oracle Argus Specialized ... services to Life Sciences companies. ... and expands HighPoint,s life sciences capabilities and provides ...
(Date:2/8/2016)... , Switzerland and PALO ALTO, Calif. ... in biological and chemical manufacturing, and Kodiak Sciences Inc., ... the treatment of retinal disease, announced today agreements for ... agreement, Lonza will manufacture material at multiple sites, including ... --> --> Retinal diseases, ...
Breaking Medicine Technology: