Navigation Links
Identification of gene

The mystery of what causes the fatal autoimmune disease Systemic Lupus Erythematosis has been solved by the identification of a possible genetic link.

Researchers at the University of California, San Diego School of Medicine (UCSD) uncovered the possible genetic link to SLE. Their report in a nationa journal say that a gene has been identified in mice which, if absent, causes symptoms remarkably similar to human SLE.//

SLE is an incurable and potentially fatal multi-organ disease that turns victims’ immune systems against them. The disease affects about one in 300 people, 90 per cent of them being women.It causes damage to kidneys, liver, brain, heart, spleen, joints, and lungs.

The investigators from UCSD,found that mice with a genetic mutation in an enzyme called alpha-mannosidase II develop lupus-type symptoms. This enzyme helps to form cell-surface carbohydrate structures called N-glycans, which enable the immune system to distinguish self from non-self.

In people with lupus and other autoimmune diseases such as arthritis, the body’s white blood cells, instead of destroying invading bacteria and viruses, attack normal organs. While these cells appear normal in lupus sufferers, the victims’ tissues and organs still appear ravaged by an attacking immune system.

Researchers had previously noticed that changes in N-glycans could lead to autoimmune disease. After pinpointing a gene which produces an enzyme that starts the glycan formation pathway, researchers bred mice without this gene. They found the gene-deficient mice had much lower levels of N-glycans, and abnormally shaped N-glycans molecules. At the same time, these mice had high levels of antibodies, kidney inflammation and other tissue damage.

Senior author of the study, Professor Jamey Marth said: "this is an entirely new manner by which autoimmune disease can occur, by a gene controlling carbohydrate formation. These findings provide new ins ights into understanding autoimmune disease and suggest new diagnostic tests for possible causes of human SLE ".


'"/>




Related medicine news :

1. New Gene Identification Help Asthma Treatments
2. The Use of Radio Frequency Identification ( RFID) to tackle the growing menace of counterfeit drugs
3. Protein Markers for Identification of Brain Tumor
4. Identification Of Gene Sequence To Promote Growth Of New Arteries
5. Colour Identification Lies Wholly On the Left Hemisphere of the Brain.
6. Novel Technique For Identification And Treatment Of Neurodegenerative Diseases
7. Combined Imaging Approach may Provide Better Identification of Difficult-to-diagnose Brain Clots
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... Rey, CA (PRWEB) , ... March 23, 2017 ... ... its customizable coding audit software solution, iCode Assurance, at HCCA’s 21st annual Compliance ... optimizes and accelerates the coding audit process for all medical chart types with ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... “Wounded Woman ... “Wounded Woman Be Ye Healed-Passing On A Legacy” is the creation of published author, ... founder of Comfortbearers grief ministry. She has been happily married to her husband, ...
(Date:3/23/2017)... ... 2017 , ... “A Respectful Response To Atheist Manifesto”: theological ... Manifesto” is the creation of published author Richard Hostetter, a former missionary in ... holds graduate degrees from Kent State University and the University of Ghana. , ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... the publication of “Profiling protein expression in circulating tumor cells using microfluidic western ... the use of the Vortex technology to capture CTCs and a ...
(Date:3/22/2017)... (PRWEB) , ... March 23, 2017 , ... ... technologies and development solutions for drugs, biologics and consumer health products, today announced ... BioPharma Asia Convention, currently taking place at the Suntec Singapore International Exhibition & ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... Mass. , March 23, 2017 Merrimack ... enrollment of its first patient in a Phase 1 ... antibody-directed nanotherapeutic (ADN) that encapsulates a novel taxane and ... is overexpressed in 50-100% of many major tumor types, ... "The initiation of this study is an ...
(Date:3/23/2017)... , March 23, 2017 Global Colposcope Market ... on the Colposcope in Global market, especially in North ... Asia-Pacific , South America , ... report categorizes the market based on manufacturers, regions, type and application. ... Browse 190 Tables ...
(Date:3/23/2017)... 23, 2017 NeuroVive Pharmaceutical AB (Nasdaq ... that the English version of the Annual report for 2016 ... ... NeuroVive NeuroVive Pharmaceutical AB is a leader in ... development of medicines that preserve mitochondrial integrity and function in ...
Breaking Medicine Technology: