Navigation Links
Identification of gene

The mystery of what causes the fatal autoimmune disease Systemic Lupus Erythematosis has been solved by the identification of a possible genetic link.

Researchers at the University of California, San Diego School of Medicine (UCSD) uncovered the possible genetic link to SLE. Their report in a nationa journal say that a gene has been identified in mice which, if absent, causes symptoms remarkably similar to human SLE.//

SLE is an incurable and potentially fatal multi-organ disease that turns victims’ immune systems against them. The disease affects about one in 300 people, 90 per cent of them being women.It causes damage to kidneys, liver, brain, heart, spleen, joints, and lungs.

The investigators from UCSD,found that mice with a genetic mutation in an enzyme called alpha-mannosidase II develop lupus-type symptoms. This enzyme helps to form cell-surface carbohydrate structures called N-glycans, which enable the immune system to distinguish self from non-self.

In people with lupus and other autoimmune diseases such as arthritis, the body’s white blood cells, instead of destroying invading bacteria and viruses, attack normal organs. While these cells appear normal in lupus sufferers, the victims’ tissues and organs still appear ravaged by an attacking immune system.

Researchers had previously noticed that changes in N-glycans could lead to autoimmune disease. After pinpointing a gene which produces an enzyme that starts the glycan formation pathway, researchers bred mice without this gene. They found the gene-deficient mice had much lower levels of N-glycans, and abnormally shaped N-glycans molecules. At the same time, these mice had high levels of antibodies, kidney inflammation and other tissue damage.

Senior author of the study, Professor Jamey Marth said: "this is an entirely new manner by which autoimmune disease can occur, by a gene controlling carbohydrate formation. These findings provide new ins ights into understanding autoimmune disease and suggest new diagnostic tests for possible causes of human SLE ".


'"/>




Related medicine news :

1. New Gene Identification Help Asthma Treatments
2. The Use of Radio Frequency Identification ( RFID) to tackle the growing menace of counterfeit drugs
3. Protein Markers for Identification of Brain Tumor
4. Identification Of Gene Sequence To Promote Growth Of New Arteries
5. Colour Identification Lies Wholly On the Left Hemisphere of the Brain.
6. Novel Technique For Identification And Treatment Of Neurodegenerative Diseases
7. Combined Imaging Approach may Provide Better Identification of Difficult-to-diagnose Brain Clots
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/17/2019)... BROOKFIELD, Wis. (PRWEB) , ... September 17, 2019 , ... Milwaukee-area dealership Hall Cars has ... have been affected by cancer. The event, entitled “Drive Out Cancer,” entails that for every ... This Time Tomorrow Foundation. As the event lasts for 50 days, it has also been ...
(Date:9/17/2019)... , ... September 17, 2019 , ... ... for Europe and the 21st Century Cures Act in the US, Nocimed has ... and pain management. Using images from existing MRI equipment to perform MR ...
(Date:9/17/2019)... ... September 17, 2019 , ... Drs. Charles Felts and ... teeth in Chattanooga, TN for customized full mouth dental implants with TeethXpress® ... one day, providing a permanent tooth replacement solution for patients who struggle with ...
(Date:9/17/2019)... ... ... Lubin Austermuehle, P.C. will be one of the sponsors of GRIN2B ... Found Kitchen and Social House in Evanston on Monday, October 7 from 6 p.m. ... rare condition that results from changes to the GRIN2B gene. The GRIN2B gene is ...
(Date:9/17/2019)... ... September 17, 2019 , ... Genomenon ... with the goal of providing resources to assist researchers and encourage pharmaceutical companies ... disease causing abnormal iron deposits in the brain. , BPAN Warriors is ...
Breaking Medicine News(10 mins):
(Date:9/18/2019)... ... 2019 , ... Lake Minnetonka Orthodontics, with locations in Minnetonka, ... Hybrid-Responsive™ website: https://www.lakeminnetonkaortho.com . , The staff of Lake Minnetonka Orthodontics ... with the practice more easily online. Improvements include increased usability, online scheduling, and ...
(Date:9/18/2019)... , ... September 18, 2019 , ... The interns of ... all attended the Youth Consultation Services Foundation (YCS) in Hackensack , where NJ ... spent time with the children and threw them a pizza party and handed out ...
(Date:9/17/2019)... AUCKLAND, New Zealand (PRWEB) , ... September 17, 2019 , ... ... Mention in in Fast Company’s 2019 Innovation by Design Awards Students category. , It ... Lab at the Auckland Bioengineering Institute. , Muss-Bits is comprised of two parts. A ...
Breaking Medicine Technology: