Navigation Links
Identification Of Gene Sequence To Promote Growth Of New Arteries

A Research headed by the vascular surgeon Rajabrata Sarkar, MD, PhD, at the San Francisco VA Medical Center has unraveled the genetic mechanism that helps in the growth of new arteries // . He demonstrated in mice that the MMP2 gene is the key factor for the development of new arteries especially when there is blockage in the femoral (leg) artery.

As a novel approach the team has analyzed and given detailed information on the DNA sequence of the MMP2 gene, which encodes an enzyme believed to promote the growth of new arteries. This can be found in the November 8 issue of the Proceedings of the National Academy of Sciences.

Understanding the development of new arteries is very essential because when there is an insufficient blood flow to the leg, it can lead to gangrene, necessitating leg amputations under worse conditions.

Sarkar and his researchers (University of California, San Francisco) conducted a study in which two sets of mice were taken and human vascular disease was mimicked in the femoral arteries in both the sets, normal mice having the intact gene and the other lacking the MMP2 gene. In about three weeks, the normal mice developed new arteries and the blood flow was restored close to normal levels. In the other set of mice that lacked MMP2 gene, new arteries failed to grow and 40% of these lost a part of their leg as a result of gangrene. This shows that the gene is vital for the growth of new arteries when there is blockage.

The research team also studied accurately those areas of the MMP2 gene that were activated in skeletal muscles when there was a decrease in the blood flow. The transgenic mice created, by David Lovett, provided a representation of the arterial blockage.

The beta galactosidase gene marker was incorporated into the transgenic mice, which turns tissues blue. Different strains of the mice had different fragments of the MMP2 gene linked to the marker gene. When there is an arterial blocka
'"/>




Page: 1 2

Related medicine news :

1. New Gene Identification Help Asthma Treatments
2. The Use of Radio Frequency Identification ( RFID) to tackle the growing menace of counterfeit drugs
3. Identification of gene
4. Protein Markers for Identification of Brain Tumor
5. Colour Identification Lies Wholly On the Left Hemisphere of the Brain.
6. Novel Technique For Identification And Treatment Of Neurodegenerative Diseases
7. Combined Imaging Approach may Provide Better Identification of Difficult-to-diagnose Brain Clots
8. Dog (Mans best friend) Genome Sequenced
9. New Technique Enables Better Nursing Of Robin Sequence Infants
10. Human Complexity Can Be Attributed To Regulatory Sequence
11. NHGRI Aims To Sequence Primate Genomes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Identification Gene Sequence Promote Growth New Arteries

(Date:3/28/2015)... 28, 2015 The California-based leading wig ... every customer shopping on UniWigs during the Easter Holidays ... a big promotion on April Fools’ Day. , As ... just around the corner. Easter Festival, with religious origins ... a major holiday after Christmas. The best wig provider, ...
(Date:3/28/2015)... IL (PRWEB) March 28, 2015 Centurion Service ... equipment auction on Thursday, April 2 at their Las Vegas ... Vegas, NV 89081. The sale, which consists of equipment from ... begin promptly at 9 a.m. PDT. , Buyers will ... and surgery equipment. “We are a one-stop-shop,” said Erik Tivin, ...
(Date:3/28/2015)... Las Vegas, NV (PRWEB) March 28, 2015 ... stiffness may not be necessary, according to research presented ... ( AOSSM ) Specialty Day. , “Our study compared ... with 25 who underwent an additional glenohumeral joint capsule ... surgery,” commented George Murrell MD, PhD, lead author from ...
(Date:3/28/2015)... 2015 Lately the student-athlete experience ... changes and proposals around the NCAA. In a March ... collegiate student-athletes across a spectrum of universities and sports ... challenges. The special panel consists of athletes who have ... from football, track and field, baseball, and volleyball. They ...
(Date:3/28/2015)... Aliso Viejo, California (PRWEB) March 28, 2015 ... have announced a new overlay entitled Scratches 5K from ... overlay grungy scratch effects to any media inside Final ... Film Studios. “StoryBoard Corporate saves time and is an ... any media using FCPX Overlay Scratches 5K's intuitive grunge ...
Breaking Medicine News(10 mins):Health News:UniWigs Is Sending Out Mysterious Gifts During the Easter Holidays 2Health News:Medical Equipment Auction to Take Place in North Las Vegas 2Health News:No Need to Delay Rotator Cuff Surgery, Study Shows 2Health News:SCI TV Panel of Former College Athletes Discusses Student Athlete Experience 2Health News:SCI TV Panel of Former College Athletes Discusses Student Athlete Experience 3Health News:Pixel Film Studios Unveiled Scratches 5k for Final Cut Pro X Editors 2
... SCOTTSDALE, Ariz., Oct. 30 Changing Times,Vitamins, Inc., ... Las Vegas,has become a distributor for its primary ... tested, patent pending algae extract that has,been shown ... immune system. The beverage has no empty calories, ...
... Clinicians, Need for Detailed, Life-Saving Overdose,Information at the ... in November, TAMPA, Fla., Oct. 30 ... overdose references, Gold Standard Inc.,has re-launched ToxED ... toxicology reference addresses clinicians, need for,quick access to ...
... to acid in the mouth is the culprit, pediatric dentist ... its avalanche of candy is coming, making it the worst ... says a dentist who contends that parents can make a ... , "Parents need to know that frequency is far ...
... 30 Palomar Medical,Technologies, Inc. (Nasdaq: PMTI ... for cosmetic treatments, today announced financial,results for the ... the,quarter ended September 30, 2008 were $24.2 million, ... were royalty revenues, $1.0 million,were funded development revenues, ...
... Rally Residents to Eat Right, Move ... More and Milk Their Diets, WASHINGTON, Oct. ... of different fad diets -- which seem to go in and out ... out of three Americans -- including 22% of D.C. area residents --,remain ...
... SAN JUAN, Puerto Rico, Oct. 30 Triple-S,Management Corporation ... in,Puerto Rico, today announced record consolidated revenues for the ... million, or $0.29 per,diluted share, includes an after tax ... in net realized and unrealized losses on investments and,derivatives. ...
Cached Medicine News:Health News:Coors of Las Vegas Becomes New Distributor of RecoveryX 2Health News:Gold Standard Re-launches ToxED Clinical Toxicology Poisoning and Drug Overdose Reference 2Health News:Gold Standard Re-launches ToxED Clinical Toxicology Poisoning and Drug Overdose Reference 3Health News:Gold Standard Re-launches ToxED Clinical Toxicology Poisoning and Drug Overdose Reference 4Health News:Halloween Candy: It's Not How Much Kids Eat, It's When 2Health News:Halloween Candy: It's Not How Much Kids Eat, It's When 3Health News:Palomar Medical Reports Financial Results for Third Quarter 2008 2Health News:Palomar Medical Reports Financial Results for Third Quarter 2008 3Health News:Palomar Medical Reports Financial Results for Third Quarter 2008 4Health News:Palomar Medical Reports Financial Results for Third Quarter 2008 5Health News:Palomar Medical Reports Financial Results for Third Quarter 2008 6Health News:Palomar Medical Reports Financial Results for Third Quarter 2008 7Health News:Palomar Medical Reports Financial Results for Third Quarter 2008 8Health News:Palomar Medical Reports Financial Results for Third Quarter 2008 9Health News:Message to Washington D.C. Residents: Forgo Fad Dieting and Join the Campaign for Healthy Weight 2Health News:Message to Washington D.C. Residents: Forgo Fad Dieting and Join the Campaign for Healthy Weight 3Health News:Triple-S Management Corporation Reports Third Quarter 2008 Results; Board Approves Share Repurchase Authorization of up to $40 Million 2Health News:Triple-S Management Corporation Reports Third Quarter 2008 Results; Board Approves Share Repurchase Authorization of up to $40 Million 3Health News:Triple-S Management Corporation Reports Third Quarter 2008 Results; Board Approves Share Repurchase Authorization of up to $40 Million 4Health News:Triple-S Management Corporation Reports Third Quarter 2008 Results; Board Approves Share Repurchase Authorization of up to $40 Million 5Health News:Triple-S Management Corporation Reports Third Quarter 2008 Results; Board Approves Share Repurchase Authorization of up to $40 Million 6Health News:Triple-S Management Corporation Reports Third Quarter 2008 Results; Board Approves Share Repurchase Authorization of up to $40 Million 7Health News:Triple-S Management Corporation Reports Third Quarter 2008 Results; Board Approves Share Repurchase Authorization of up to $40 Million 8Health News:Triple-S Management Corporation Reports Third Quarter 2008 Results; Board Approves Share Repurchase Authorization of up to $40 Million 9Health News:Triple-S Management Corporation Reports Third Quarter 2008 Results; Board Approves Share Repurchase Authorization of up to $40 Million 10Health News:Triple-S Management Corporation Reports Third Quarter 2008 Results; Board Approves Share Repurchase Authorization of up to $40 Million 11Health News:Triple-S Management Corporation Reports Third Quarter 2008 Results; Board Approves Share Repurchase Authorization of up to $40 Million 12Health News:Triple-S Management Corporation Reports Third Quarter 2008 Results; Board Approves Share Repurchase Authorization of up to $40 Million 13Health News:Triple-S Management Corporation Reports Third Quarter 2008 Results; Board Approves Share Repurchase Authorization of up to $40 Million 14Health News:Triple-S Management Corporation Reports Third Quarter 2008 Results; Board Approves Share Repurchase Authorization of up to $40 Million 15Health News:Triple-S Management Corporation Reports Third Quarter 2008 Results; Board Approves Share Repurchase Authorization of up to $40 Million 16
(Date:3/27/2015)... March 27, 2015  Holographic Optical Technologies of ... of holographic medical imaging, is entering the world of ... Launching on April 20 th , 2015, the campaign ... The 8-inch and 22-inch displays will allow consumers to ... first time. In addition to the two displays, the ...
(Date:3/27/2015)... 27, 2015   Cypher Genomics, Inc., ... data showing that, compared to a panel of ... highly equivalent interpretations of whether certain genetic abnormalities ... in a fraction of the time. Cypher,s Mantis ... comprehensive genetic analysis in non-invasive prenatal testing (NIPT) ...
(Date:3/27/2015)... , March 27, 2015 XRpro Sciences, ... drug discovery and development services which features high ... pharmaceutical industry, announced financial results for the year ... C.  Tyson, Chairman of XRpro Sciences commented, "We ... transition from development stage to commercial stage in ...
Breaking Medicine Technology:Holographic Optical Technologies brings cutting-edge holograms to consumer market through upcoming Kickstarter campaign 2Holographic Optical Technologies brings cutting-edge holograms to consumer market through upcoming Kickstarter campaign 3New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 2New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 3XRpro Sciences Announces Fiscal 2014 Financial Results 2XRpro Sciences Announces Fiscal 2014 Financial Results 3XRpro Sciences Announces Fiscal 2014 Financial Results 4
... PARIS, October 24 Novexel, a speciality pharmaceutical,company ... antibiotics,designed to overcome the significant global problem of ... subject of five posters,at the joint annual meeting ... and the Infectious Disease Society of America (48th,annual ...
... - An Insulin Suppository Represents an Important Development ... Painless Alternative for Effective,Insulin Delivery, Oramed Pharmaceuticals, ... alternative drug delivery systems, announced today that it ... Council (MCC) to,begin conducting Phase 1A trials on ...
Cached Medicine Technology:Novexel to Present Five Posters at the Joint Annual Interscience Conference on Antimicrobial Agents and Chemotherapy and the Infectious Disease Society of America (ICAAC/IDSA) Meeting 2Oramed Pharmaceuticals Launches Phase 1A Trials of its Insulin Suppository 2Oramed Pharmaceuticals Launches Phase 1A Trials of its Insulin Suppository 3
18 gauge curved. Fine tip. Lightweight design offers precise hemostasis. Pencil design minimizes tissue trauma and induced astigmatism. Knurled handle provides a sure grip and better manipulation....
Straight, soft flexible tip allows atraumatic entry through a retinal tear or hole for aspiration of subretinal fluids. 20 gauge x 25 mm cannula attached to 25 gauge x 6 mm tip with 13 mm flexible tu...
Sharp tip with cutting edge bent to 50 degrees fits 19 gauge or 20 gauge instrument port, 20 gauge instrument port, 20 gauge x 25 mm tapering to 25 gauge x 4.76 mm. 10 per box....
Developed for oculoplastic procedures for corneal and scleral protection. Dimensions enable protector to rest on the sclera and not on the cornea. Easily removed with Bishop-Harmon Forceps. Individua...
Medicine Products: