Navigation Links
Identification Of Gene Sequence To Promote Growth Of New Arteries

A Research headed by the vascular surgeon Rajabrata Sarkar, MD, PhD, at the San Francisco VA Medical Center has unraveled the genetic mechanism that helps in the growth of new arteries // . He demonstrated in mice that the MMP2 gene is the key factor for the development of new arteries especially when there is blockage in the femoral (leg) artery.

As a novel approach the team has analyzed and given detailed information on the DNA sequence of the MMP2 gene, which encodes an enzyme believed to promote the growth of new arteries. This can be found in the November 8 issue of the Proceedings of the National Academy of Sciences.

Understanding the development of new arteries is very essential because when there is an insufficient blood flow to the leg, it can lead to gangrene, necessitating leg amputations under worse conditions.

Sarkar and his researchers (University of California, San Francisco) conducted a study in which two sets of mice were taken and human vascular disease was mimicked in the femoral arteries in both the sets, normal mice having the intact gene and the other lacking the MMP2 gene. In about three weeks, the normal mice developed new arteries and the blood flow was restored close to normal levels. In the other set of mice that lacked MMP2 gene, new arteries failed to grow and 40% of these lost a part of their leg as a result of gangrene. This shows that the gene is vital for the growth of new arteries when there is blockage.

The research team also studied accurately those areas of the MMP2 gene that were activated in skeletal muscles when there was a decrease in the blood flow. The transgenic mice created, by David Lovett, provided a representation of the arterial blockage.

The beta galactosidase gene marker was incorporated into the transgenic mice, which turns tissues blue. Different strains of the mice had different fragments of the MMP2 gene linked to the marker gene. When there is an arterial blocka ge in the strain of mice with the specific gene sequence, the leg muscles turn blue. Hence this paved way for the researchers to specifically spot new areas within the MMP2 gene and other adjuvant molecules that are necessary for the expression of the gene during decreased blood flow.

As it is a fundamental approach to understand the pathway of the gene involved in the growth of arteries, further research has to be done to understand the various conditions like cigarette smoking, high cholesterol, diabetes, and hypertension in relation with vascular diseases according to the researchers.

The research teams intend to study the same genetic mechanisms in humans, with the tissue samples taken from patients during surgery. It is hoped that this research would eventually pave way for the development of novel treatment modalities towards ‘curing’ patients with arterial blockage.


'"/>




Related medicine news :

1. New Gene Identification Help Asthma Treatments
2. The Use of Radio Frequency Identification ( RFID) to tackle the growing menace of counterfeit drugs
3. Identification of gene
4. Protein Markers for Identification of Brain Tumor
5. Colour Identification Lies Wholly On the Left Hemisphere of the Brain.
6. Novel Technique For Identification And Treatment Of Neurodegenerative Diseases
7. Combined Imaging Approach may Provide Better Identification of Difficult-to-diagnose Brain Clots
8. Dog (Mans best friend) Genome Sequenced
9. New Technique Enables Better Nursing Of Robin Sequence Infants
10. Human Complexity Can Be Attributed To Regulatory Sequence
11. NHGRI Aims To Sequence Primate Genomes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, ... treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including robotic ... osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, ... minimum wage raise to $12 an hour by 2020 and then adjusting it yearly to ... value of the minimum wage, assure the wage floor does not erode again, and make ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. ... articles published in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... The Grove Investment Group (TGIG), has initiated cultivation and processing operations at its ... Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete system ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm ... sciences executive with extensive sequencing and genomics experience, as Vice President of North American ... Hill will be responsible for leading the sales team in the commercialization of the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... , June 24, 2016 According ... by Type (Standard Pen Needles, Safety Pen Needles), Needle ... GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) - ... This report studies the market for the forecast period ... reach USD 2.81 Billion by 2021 from USD 1.65 ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
Breaking Medicine Technology: