Navigation Links
IMRT Versus 3D CRT For Prostate Cancer, New Long-Term Data Assesses Side Effects

New research findings show men have fewer long-term gastrointestinal side effects with intensity-modulated radiation therapy (IMRT) than with three-dimensional// conformal radiation therapy (3D CRT) for prostate cancer treatment, despite the higher doses of radiation used in the IMRT group. These and other data, including long-term genitourinary side effects, were presented today at the 48th Annual Meeting of the American Society for Therapeutic Radiology and Oncology in Philadelphia.

Long-term data comparing 3D CRT for prostate cancer versus the use of IMRT is only now beginning to mature. Few other academic treatment centers have as much experience with 3D CRT and IMRT as Fox Chase.

Both techniques allow precise targeting of the cancer with multiple X-ray beams, but IMRT allows physicians to modulate the radiation dose intensity with far smaller radiation beams. Thus, doses of radiation to the bladder and rectum can be limited. Reducing radiation exposure to healthy normal tissue and other vital organs helps prevent once common side effects such as urinary frequency and diarrhea.

In the study presented today, researchers analyzed data collected prospectively from 1,417 patients treated at Fox Chase. Of these, 928 men were treated with 3D CRT (median follow-up of 63.3 months) and 489 men with IMRT (median follow-up of 29.9 months). The IMRT patients received higher doses of radiation.

Patients were matched for PSA level (prostate specific antigen, measured by a blood test and used to determine if prostate cancer is present), T-stage (palpable size) and Gleason score (tumor aggressiveness determined by pathologic testing). The researchers evaluated gastrointestinal side effects such as short-term diarrhea and longer-term bowel dysfunction and genitourinary side effects such as urinary frequency, urgency and, rarely, painful or difficult urination or obstructive symptoms.

"There were no differences in the reporting of acute gastrointestinal or genitourinary side effects for the two treatment modalities," explained Alexander Kirichenko, M.D., Ph.D., lead author of the study and a clinical fellow at Fox Chase at the time of the analysis. "However, as the data are beginning to mature, we're seeing more long-term gastrointestinal side effects in the men treated with 3D CRT." Kirichenko is now a radiation oncologist at Allegheny General Hospital in Pittsburgh, Pa. Even though patients treated with IMRT had higher doses of radiation, there were fewer gastrointestinal side effects three years after treatment (6.3% for IMRT; 10.4% in 3D CRT). The research showed no statistically significant difference between the two treatment types for genitourinary side effects.

Kirichenko concluded, "Despite the specific findings pertaining to 3D CRT technique and the gastrointestinal side effects, men treated with either modality have acceptable rates of side effects at this point in our analysis particularly when compared to data from surgical outcomes."

Source-Eurekalert
'"/>




Related medicine news :

1. Rituximad Can Treat Chronic Graft-Versus-Host Disease: Study
2. Cancer Doctors Okays Controversial Prostate Therapy
3. Radioactive Seeds used in Prostate Cancer treatment can migrate with the body
4. New Prostate Cancer Vaccine Shows Promise
5. Hormone Therapy applicable for Prostate Cancer
6. Prostate cancer and Vitamins
7. Response to chemotherapy could be measured by Prostate-Specific Antigen Doubling Time
8. Early Detection Of Prostate Cancer
9. Awareness increase Prostate cancer detection
10. Better Prostate Cancer Test
11. Stopping Prostate Cancer from Spreading
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... MIAMI, Fla. (PRWEB) , ... June 24, 2016 , ... ... Florida Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this ... of Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this ...
(Date:6/24/2016)... ... ... Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair ... hour by 2020 and then adjusting it yearly to increase at the same rate as ... the wage floor does not erode again, and make future increases more predictable. , The ...
(Date:6/24/2016)... NY (PRWEB) , ... June 24, 2016 , ... ... Haute Living, is proud to recognize Dr. Barry M. Weintraub as a prominent ... “the most beautiful women in the world, and the most handsome men, look ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... --  Pulmatrix, Inc ., (NASDAQ: PULM ), ... today that it was added to the Russell Microcap ... set of U.S. and global equity indexes on June ... for Pulmatrix," said Chief Executive Officer Robert Clarke ... in developing drugs for crucial unmet medical needs, and ...
(Date:6/23/2016)... June 23, 2016  MedSource announced today that ... e-clinical software solution of choice.  This latest decision ... value to their clients by offering a state-of-the-art ... relationship establishes nowEDC as the EDC platform of ... full-service clients.  "nowEDC has long been a preferred ...
(Date:6/23/2016)... , June 23, 2016 Research ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, ... (Oral, Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is ... a CAGR of 6.1% in the forecast period 2016 ...
Breaking Medicine Technology: