Navigation Links
IBS Sufferers Benefited by Non-Absorbable Antibiotics

A non absorbable antibiotic which stays in the gut has been found to be an effective long-term treatment for irritable// bowel syndrome (IBS) according to researchers at Cedars-Sinai Medical Center.

The study has been published in the October 17 issue of the Annals of Internal Medicine It is the first to demonstrate benefits from antibiotic use even after end of the course of treatment has ended. This study has supported previously published research that identified small intestine bacterial overgrowth as a cause of the disease.

This study was a randomized, double-blind, placebo-controlled study involving 87 participants, all of whom met specific multinational guidelines for diagnosis of IBS. They received 400 mg of the antibiotic rifaximin three times a day for 10 days or a placebo.

The participants were required to complete an extensive symptom questionnaire at the start of the study and then weekly for 10 weeks following treatment. The questionnaire measured the severity of nine symptoms (abdominal pain, constipation, diarrhea, urgency, bloating, sense of incomplete evacuation, incomplete evacuation, mucus, and gas). Patients were also asked to provide a% global improvement from 0 to 100% in their overall IBS symptoms.

The study revealed that rifaximin not only led to significant improvement in global IBS symptoms during the 10 days it was administered, but showed a continuance of the benefit continued for the 10 weeks of follow up when no antibiotic was given, showing sustained benefit.

Mark Pimentel, M.D., director of the GI Motility Program at Cedars-Sinai and the study's principal investigator said, "The fact that the benefit of the targeted antibiotic continued even after it was stopped provides evidence that the antibiotic was acting on a source of the problem: excess bacteria in the gut. This finding offers a new treatment approach -- and a new hope -- for people with IBS."

Irritable Bowe l Syndrome affects about 20% of Americans and is one of the top 10 most frequently diagnosed conditions by U.S. physicians. The disorder is characterized by abdominal pain, cramping, bloating and diarrhea and/or constipation and is a long-term condition that usually begins in early adult life. The episodes may be mild or severe and may be exacerbated by stress and is more common in women than in men.

Pimentel said, "While this study being released today demonstrates that the non-absorbed antibiotic rifaximin has great promise in the clinical improvement of IBS, more research is needed. Next steps include multi-center studies to further assess short- and long-term benefits of this drug. Tests comparing rifaximin to other types of antibiotics that have been used to treat the disease should also be conducted."

Treatments for this disease have been mainly focused on reducing its symptoms because researchers are still clueless about its cause. In the Dec 2000 issue of American Journal of Gastroenterology, Pimentel linked bloating, the most common symptom of IBS, to bacterial fermentation by giving lactulose breath tests to participants.

This test monitors the level of hydrogen and methane on the breath and showed evidence that small intestine bacteria overgrowth may be a causative factor in IBS. The current Annals study participants also took the breath tests, which showed similarly increased levels of hydrogen and methane.

Rifaximin is manufactured by Salix Pharmaceuticals, Inc. Funding for the study was also provided by Salix. The discovery related to the use of rifaximin for IBS was made at Cedars-Sinai by Pimentel. Cedars-Sinai holds patent rights to this discovery and has licensed rights to the invention to Salix.
NLA
'"/>




Related medicine news :

1. Another ray of hope for Arthritis Sufferers
2. Do Asthma Sufferers Lack Physical Activity?
3. Asthma Sufferers Lacking Physical Activity
4. Hope for Dust Mite Allergy Sufferers
5. Promise for Soya Allergy Sufferers
6. AIDS Sufferers Protest against Proposed Patent for Tenofovir
7. Zambia Struggling To Identify AIDS Sufferers
8. Celiac Disease Sufferers See an End to their Misery
9. AIDS Sufferers Turn to British Doctor to Prolong their Survival
10. Exercise DVD Available For COPD Sufferers
11. Sleep Apnea Sufferers-Viagra May Make The Condition Worse
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris ... of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking ... in the field of medical informatics, this prestigious award is presented to an individual ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, the Los ... article to the newly revamped Cosmetic Town journal section, featuring articles ... procedure known as Follicular Unit Extraction (FUE). , Dr. Mohebi says ...
(Date:10/12/2017)... ... 2017 , ... On Saturday, October 21, the Health & Wellness Center at ... raise money for the American Heart Association Heart Walk. Teams of up to 10 ... to keep their treadmills moving for 5 hours. Treadmills will start at 7:00 p.m. ...
(Date:10/12/2017)... ... October 12, 2017 , ... In the United States, single-family ... some states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average ... extremely low property-tax rates, which contributes to the relatively lower cost of living ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vodori, Inc., ... promotional review platform at the Promotional Review Committee Compliance and Best Practices ... streamline the medical, legal, and regulatory review (MLR) process – which ensures ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... , Oct. 5, 2017  In response ... of Oral and Maxillofacial Surgeons (AAOMS) released prescribing ... – to be used as a first-line therapy ... Recognizing the ... AAOMS White Paper "Opioid Prescribing: Acute and Postoperative ...
(Date:10/2/2017)... INDIANAPOLIS , Oct. 2, 2017  Eli Lilly ... its financial results for the third quarter of 2017 ... a conference call on that day with the investment ... performance. The conference call will begin at ... public can access a live webcast of the conference ...
(Date:9/28/2017)... , Sept. 28, 2017 Cohen Veterans Bioscience ... the use of wearable and home sensors for real-time ... Early Signal Foundation, a nonprofit organization focused on disruptive ... provide an affordable analytical system to record and integrate ... ...
Breaking Medicine Technology: