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Hyperthermia With Chemotherapy Improves Sarcoma Healing

ological research - in the question whether certain sarcomas could be better treated with a combination of hyperthermia and other forms of therapy.

In the course of local, deep hyperthermia, tumours are warmed to 40-44 Celsius, with, the aid of electromagnetic waves. At temperatures of 42 C, cells begin to die, on account of the heat. The combination therapy developed at GSF and the Grohadern Medical Centre exploits the fact that tumour cells are more vulnerable at 40 C to the immune system and also to radiotherapy and chemotherapy.

In the past years, the results gained in the treatment of sarcomas have encouraged the research group to apply their knowledge to other forms of tumour.

At the present time, within the framework of a part body hyperthermia project plan, they are investigating whether the combination of chemotherapy and radiotherapy with hyperthermia leads to better treatment results in cases of colon and rectum cancers and of pancreatic carcinoma, as well.

Under the guidance of GSF, a Virtual Institute of Excellence has been founded between the Clinical Co-operation Group Hyperthermia at the Grohadern Medical Centre and the Medical Clinic Charite Berlin, in order to promote the project plan, which will initially be sponsored for three years by the Initiative and Networking Fund of the Helmholtz Association of German Research Centres.

The Scientific Technical Director of GSF, Prof. Dr Wess, regards this as a successful example of translational research. The concept of research in co-operation groups together with clinical partners and the creation of clinical research platforms is an essential prerequisite for the prompt application of knowledge from fundamental research to clinical practice and vice versa.

Contact the GSF Press Office: GSF - Forschungszentrum fr Umwelt und Gesundheit Abteilung Kommunikation Tel: 089/3187-2460 Fax 089/3187-3324 E-mail: oea@gsf.
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