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Hyperthermia With Chemotherapy Improves Sarcoma Healing

Co-operation between GSF and clinic improves outlook for sarcoma patients: Effectiveness of local, deep hyperthermia proved in phase III study .

Hyperthermia, combined with chemotherapy, improves the chances of healing and survival of patients with low-lying, soft tissue sarcomas.

At the Annual General Meeting of the American Society of Clinical Oncology (ASCO) in Chicago, which ended last week, the GSF scientist, Prof. Dr Rolf D. Issels, presented the results of the first, randomised, worldwide phase III study in which the effectiveness and superiority of the combined-therapy methods are proven, in comparison with results from chemotherapy alone.

The study of 341 high-risk patients with deep, local sarcomas shows a significant improvement in the response of the tumour and in the survival of those patients who were treated by means of a combination of chemotherapy and of local, deep hyperthermia, in addition to operative removal of the sarcoma. This combined therapy has been applied already to a large number of patients in advance of surgery.

The well respected study results from the Clinical Co-operation Group Hyperthermia, which has existed since 1999 between the GSF National Research Centre for Environment and Health in Munich-Neuherberg and the Grohadern Medical Centre of the University of Munich.

Their spectrum of research extends from clinical analysis of deep hyperthermia for cancer therapy up to biological research in the areas of immunobiology and cell biology.

The head of the Clinical Co-operation Group Hyperthermia, Prof. Dr Rolf Issels, has been working at GSF, since the mid-80s, on the use of local, deep hyperthermia as a cancer therapy.

From the beginning, tumours of soft tissues and bones, which start from the connective tissue and are called sarcomas, were taken as examples.

The scientists were especially interested together with related bi
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