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Hypertension Drug of Choice for African Americans

A beta-blocker called Nebivolol, may be the best drug to control high blood pressure, especially// among black Americans of African origin according to a new study.

At The International Society on Hypertension in Blacks (ISHIB2005), Nebivolol was shown to be statistically significantly better than placebo in reducing systolic and diastolic blood pressure among African-American hypertensive patients in a multicenter, randomized, double-blind, placebo-controlled study.

“Beta-blockers are under-utilized among African Americans due to the perception that this form of anti-hypertensive medication is not effective,” stated Dr. Saunders, who was one of the researcher of the study, he also added: “This study shows that nebivolol lowered blood pressure in a dose-dependent manner and was well-tolerated”.

The study found no statistically significant differences in the incidence of adverse events between the nebivolol and placebo groups. The most commonly reported adverse events were: headache (5.6% vs 4.1%, respectively); dizziness (3.6% vs 0%, respectively); arthralgia (3.6% vs 2.0%, respectively); diarrhea (3.2% vs 2.0%, respectively); fatigue (2.8% vs 0%, respectively); nasopharyngitis (2.4% vs 0%, respectively); and urinary tract infections (2.4% vs 0%, respectively).

Nebivolol is believed to have dual action. It works by selectively blocking beta1-receptors in the heart and other organs of the body and prevents action of noradrenline and adrenaline. It also works as a modest vasodilator via enhanced release of nitric oxide,(2-3) which means it can widen the blood vessels, contributing to the maintenance of arterial pressure levels within the normal range. The combination of these two actions, as a beta-blocker and a direct vasodilator, may help provide a drug therapy that is both effective and better tolerated by the hypertensive patient.

References
1. Weiss, R. Nebivolol in the treatment of patient
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