Navigation Links
Hydroxyurea derivatives kill colon cancer cells

A new class of drugs based on a widely used anticancer drug, hydroxyurea, shows potent colon cancer-killing effects in the laboratory and in mice, according to researchers. The new compounds seem to be very interesting for the treatment of these tumors. //

Previous drugs derived from hydroxyurea were extremely active in blocking the same cell targets as hydroxyurea, but had serious side effects. This prompted the researchers to synthesize similar drugs with different structures that they hypothesized would be less likely to cause complications.

The researchers tested the drugs against colon cancer implants in mice. One of the compounds, EPH116, blocked the tumor growth at doses that did not appear toxic. EPH116 brought considerable cancer cell death, but did so by as yet unknown mechanisms. In the laboratory, EPH116 and its relatives also showed activity against small cell lung cancer and malignant melanoma cells.


'"/>




Page: 1

Related medicine news :

1. Hydroxyurea Treatment For Children With Sickle Cell Disease
2. Benzotiophene derivatives exhibit antitumor activity
3. Radiotherapy helps in colon cancer
4. Benefit of colonoscopy
5. Wheat wards off colon cancer
6. Defeating colon cancer
7. Calcium reduces colon cancer risk
8. Smoking risk precedes colon cancer
9. Implication of virus in colon cancer
10. New virtual colonoscopy procedure for easier colon screening
11. Long-term use of calcium supplements to prevent colon cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... 2017 , ... The International Association of Eating Disorders Professionals ... the field of eating disorders, announces the opening of early registration for the ... at the Omni Resort at ChampionsGate. , The annual iaedp™ Symposium ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with ... for the primary prevention of cardiovascular diseases during the 15th Annual Women’s ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , which ... evacuation of the facility as part of a disaster drill on October 3rd. , ... and Shelton City Emergency Manager, as well as the Connecticut Long Term Care ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) ... a collection of specialty vendors and unique items from across the nation, this holiday-themed ... and wellness services offered by the VNA. The boutique will be open Saturday, ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Global Healthcare ... scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare ... activity. The fun run is geared towards children of all ages; it is ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") ... Surgical facility in Las Piedras, Puerto Rico ... and blades. ... the facility sustained minor structural damage, temporary loss of ... Repairs have been completed, manufacturing operations have resumed, and ...
(Date:10/5/2017)... Oct. 5, 2017  In response to the ... and Maxillofacial Surgeons (AAOMS) released prescribing recommendations that ... be used as a first-line therapy to manage ... Recognizing the value and ... Paper "Opioid Prescribing: Acute and Postoperative Pain Management" ...
(Date:10/2/2017)... Diplomat Pharmacy, Inc. (NYSE: DPLO ... LLC , and named its founder as Diplomat,s chief ... Tennessee , will operate under Diplomat subsidiary ... offerings for health care partners to include IT outsourcing, ... "In an interoperable world, technology delivers comprehensive insight ...
Breaking Medicine Technology: