Since X-rays were discovered more than a century ago, triggering a revolution in medical imaging, clinicians have sought more powerful ways to "see" into the human body.//

Now, with a $1.1 million grant from the John R. Oishei Foundation, researchers in the University at Buffalo's Institute for Lasers, Photonics and Biophotonics are turning their expertise in nanomedicine to the development of new, nanoparticle-based multi-probe systems, launching a new generation of medical imaging. The grant will fund research in which two or more medical imaging techniques are combined to provide complementary information.

Part of a new field called nanobiotechnology, the UB scientists are designing these nanoparticle systems to contain multiple contrast agents for different imaging medical techniques.

The goal is to diagnose cancer and other diseases in their earliest stages by providing far more comprehensive data to clinicians.

"Ultimately, clinicians want the most complete data possible that they can gather from medical images, ranging from tissue structure to metabolic processes to molecular markers," said Paras Prasad, Ph.D., executive director of the Institute for Lasers, Photonics and Biophotonics and SUNY Distinguished Professor of Chemistry.

"We are aiming to provide them with such data by developing nanoparticle platforms capable of carrying multiple contrast agents for complementary medical imaging techniques in the same nano-sized package," he said.

Once injected with these multimodal nanoparticles, the patient can undergo several imaging tests, the results of which will be combined to provide more comprehensive and complementary information, such as correlations between molecular and morphological changes at the cellular level.

The result is a far more sensitive and comprehensive method of detecting the presence or progression of a disease.

"At the same time, these imagin
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