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Hunger Mapping

he physiological state of the animals.

Importantly, they found that measuring the activity of populations of neurons was a much more effective way of measuring the satiety state of an animal than measuring activity of only individual neurons in an area. And the more neurons they included in such populations, the more accurate the measure of that satiety state, they found.

Araujo and colleagues concluded that their analysis showed that while single neurons were preferentially responsive to particular phases in the metabolic status of the animal as it went through a hunger-satiety-hunger cycle, "when combined as groups, however, these neurons gained the ability to provide a population code that allows for predictions on the current behavioral state (hunger/satiety) of the animal by integrating information conveyed by its constituent units."

"Our results support the hypothesis that while single neurons are preferentially responsive to variations in metabolic status, neural groups appear to integrate the information provided by these neural sensors to maintain similar levels of activity across comparable behavioral states," they concluded. "This distributed code acting across separate hunger phases might constitute a neural mechanism underlying meal initiation under different peripheral and metabolic environments," they wrote.

Source: EurekAlert
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