Navigation Links
Humanized Antibody Therapy Found Highly Effective in Easing RA Symptoms

Medical University of Vienna researchers have shown that nearly half of patients with rheumatoid arthritis (RA), who receive tocilizumab in addition to ongoing methotrexate therapy , showed a 50 per cent improvement in the symptoms at 24 weeks.

Also one fifth of the patients achieved a 70 per cent improvement in symptoms in the same period during the study, which was presented at EULAR 2007, the Annual European Congress of Rheumatology in Barcelona.

These data show the potential of tocilizumab as a novel and attractive approach to treating RA. The symptom improvements observed across both 4mg/kg and 8mg/kg doses show that tocilizumab offers significant promise to patients with moderate and severe RA, said lead researcher Dr. Josef Smolen.

The researchers say that significant improvement in symptoms was observed in all patients receiving tocilizumab and methotrexate, compared to placebo and methotrexate.

They observed that 79.5 per cent of patients receiving tocilizumab 8mg/kg, and 61.9 per cent receiving 4mg/kg tocilizumab had achieved a good/moderate EULAR response, in comparison with placebo subjects.

A reduction in Disease Activity Score was also observed from two weeks onwards in both tocilizumab groups, say the researchers.

The study involved 623 patients with sustained moderate to severe RA despite long standing treatment with methotrexate. The subjects were permitted concurrent treatment with methotrexate at their pre-study dose, though treatment with all other disease modifying anti-rheumatic drugs was discontinued at the beginning of the trial.

Tocilizumab is a novel humanised anti human interleukin 6 (IIL-6) receptor monoclonal antibody, a cytokine involved in the pathogenesis of RA.


'"/>




Page: 1

Related medicine news :

1. Human Antibody That Can Block SARS
2. Therapeutic Monoclonal Antibody Production Is More Profitable Than Small Molecule Drugs
3. Cuba Registers New Antibody
4. Single Sugar Enables Antibody to Treat Inflammation
5. Monoclonal Antibody based system for Anthrax detection
6. Monoclonal Antibody Reduces Exacerbations in Asthmatics
7. Anti-rejection Therapy a Boon for Patients With "anti-donor" Antibody Levels
8. Antibody Therapy Prevents Type 1 Diabetes
9. New Antibody for EGFR Causes Lung Cancer Regression
10. J591- an Antibody Exclusively Targets Tumors
11. Antibody-based Therapies Effective at Controlling Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/16/2017)... ... August 16, 2017 , ... The next Patient Care Academy at Kalamazoo ... Students who successfully complete the seven-week long Patient Care Academy are eligible to take ... starting salary for a CNA in Kalamazoo is $24,428.* , As a CNA, one ...
(Date:8/16/2017)... , ... August 16, 2017 , ... ... data and images announced today that it was acquired by Advantage Solutions. ... for product information. IX-ONE’s members include the industry’s leading suppliers, brokers, distributors and ...
(Date:8/16/2017)... Brentwood, TN (PRWEB) , ... August 16, 2017 ... ... market-leading dermatology practice partnerships through affiliations and de novo development, today announced ... practice. , Cumberland Skin Surgery and Dermatology, with offices in both Hermitage ...
(Date:8/16/2017)... ... 2017 , ... LabRoots , the leading provider of educational and interactive ... to announce Andrew Ly as the winner of the LabRoots Summer Textbook scholarship, awarding ... Ly, who is in his third year at the University of California, Los Angeles ...
(Date:8/16/2017)... ... August 16, 2017 , ... Fusion Flix Inc., a ... programming over four countries and millions of viewers in a partnership with the Amazon ... buy On-Demand and fully available on Blu Ray disc in 2018. Proceeds will be ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... 7, 2017  Endo International plc (NASDAQ: ... resolve virtually all known U.S. mesh product liability claims ... the known remaining U.S. claims at reasonable values. Under ... the fourth quarter of 2017 and continuing through the ... quarter 2017 results, the Company intends to increase its ...
(Date:8/3/2017)... 3, 2017  Opioid addiction and other drugs of ... costs and threatening outcomes, were problems taken on directly ... industry that support them, met this week. This according ... that drugs of abuse, procalcitonin and acute kidney injury ... organization,s 69th meeting in San Diego, CA. ...
(Date:8/2/2017)... Ore. , Aug. 2, 2017  Life Flight Network ... Agreement. The agreement improves patient care and operational efficiency for ... Springfield , Cottage Grove , ... level medical transportation. PeaceHealth and Life Flight Network work collaboratively ... available during transport, or when a time sensitive emergency exists. ...
Breaking Medicine Technology: