Navigation Links
Human Stem Cell Therapy Restores Motor Function to Paralyzed Rats

Scientists at the University of California, San Diego (UCSD) School of Medicine have successfully restored motor function in paralyzed rats by grafting human spinal stem cells (hSSCs) in them.

"We demonstrated that when damage has occurred due to a loss of blood flow to the spines neural cells, by grafting human neural stem cells directly into the spinal cord we can achieve a progressive recovery of motor function," said lead researcher Dr. Martin Marsala, Professor of Anesthesiology, whose study has been published in the journal Neuroscience.

"This could some day prove to be an effective treatment for patients suffering from the same kind of ischemia-induced paralysis," he added.

The researchers are currently testing the safety and efficacy of human stem cell therapy in other animal models, and may begin clinical trials in humans by next year.

Sixteen rats were induced spinal cord ischemia during the study, and then they were injected with with human spinal stem cells 21 days after paralysis. The researchers also injected seven other rats with with medium that did not contain stem cells.

They found that three of the nine rats injected with hSSCs returned to walking at six weeks, and three others had improved mobility in all lower extremity joints. All nine animals achieved significantly better motor scores than those in the control group, and showed a consistent presence of transplanted cells in the spinal area.

It was also seen that the majority of transplanted human spinal stem cells survived, and became mature neurons, according to Marsala. The researcher revealed that a second study conducted over a three-month period also furnished similar results.

The researchers believe that the therapy may eventually prove even more effective in human patients.

"Physical therapy may accelerate integration of the grafted stem cells and enhance their therapeutic be nefit," said co-author Karl Johe, a researcher at Neuralstem, the company that manufactures the hSSCs used in the study.

The researchers say that their main goal is to provide a significant gain in functional mobility of the patients legs.

"These research findings could offer great hope to people with spinal ischemic injury who suffer from resulting spasticity and rigidity," said Marsala.


'"/>




Related medicine news :

1. Human Genome Project Achieves Technological Triumph
2. First Vaccine Designed for Africa Cleared for Testing in Humans
3. Human gene number increases
4. Scientists found ancient Human Germ Killer
5. New standards for Human Research Safety
6. Human wasting disease linked to a gene
7. The Human Mad Cow Case
8. Human Growth Hormone Found To be Dangerous For Human Use
9. Human Antibody That Can Block SARS
10. Human immunity system can battle HIV.
11. Two New Human Papilloma virus (HPV) vaccines to prevent cervical cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/9/2016)... ... February 09, 2016 , ... ZipHearing.com is proud ... affordable hearing aids , increase industry transparency, and promote awareness of hearing ... , “For the average consumer, the hearing aid industry is esoteric and difficult ...
(Date:2/9/2016)... ... 09, 2016 , ... IsoComforter, Inc., one of the Nation’s ... designed, innovative shoulder wrap. The newly designed shoulder wrap has been specifically ... and shoulder to promote faster healing. It is highly recommended for arm or ...
(Date:2/9/2016)... ... February 09, 2016 , ... ... “Ebola: In Praise of Prevention,” an animated video designed to prevent ... French translations of the video are being distributed throughout Togo, Liberia, Sierra Leone, ...
(Date:2/9/2016)... ... 09, 2016 , ... i2i Systems, an early innovator and developer of population ... the latest KLAS report, Population Health Management 2015: How Far Can Your Vendor Take ... health management (PHM). The latest KLAS Report, leveraging over 200 user interviews, shines ...
(Date:2/9/2016)... VA (PRWEB) , ... February 09, 2016 , ... ... Small Mammal Prize has officially been won. A team from 21st Century Medicine ... discovered a way to preserve the delicate neural circuits of an intact rabbit ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... The leader in accelerated orthodontics, OrthoAccel ® Technologies, ... of the 2015 Townie Choice Award in the accelerated ... that speeds up orthodontic tooth movement by as much ... treatment, AcceleDent was selected by orthodontists from across the ... survey of the most reliable and reputable products in ...
(Date:2/9/2016)... N.J. , Feb. 9, 2016  Johnson & ... RBC Capital Markets Global Healthcare Conference on Tuesday, Feb. ... City.  Dominic Caruso , Vice President, Finance & ... Chairman, Consumer will represent the Company in a session ... www.investor.jnj.com . --> www.investor.jnj.com . --> ...
(Date:2/9/2016)... BETHESDA, Md. , Feb. 9, 2016 /PRNewswire-USNewswire/ ... community for pharmaceutical professionals developing and manufacturing sterile ... Global Sterile Manufacturing Regulatory Guidance Comparison – With ... regulatory guidance documents issued by the U.S. FDA, ... World Health Organization. --> ...
Breaking Medicine Technology: