Navigation Links
Human Stem Cell Therapy Restores Motor Function to Paralyzed Rats

Scientists at the University of California, San Diego (UCSD) School of Medicine have successfully restored motor function in paralyzed rats by grafting human spinal stem cells (hSSCs) in them.

"We demonstrated that when damage has occurred due to a loss of blood flow to the spines neural cells, by grafting human neural stem cells directly into the spinal cord we can achieve a progressive recovery of motor function," said lead researcher Dr. Martin Marsala, Professor of Anesthesiology, whose study has been published in the journal Neuroscience.

"This could some day prove to be an effective treatment for patients suffering from the same kind of ischemia-induced paralysis," he added.

The researchers are currently testing the safety and efficacy of human stem cell therapy in other animal models, and may begin clinical trials in humans by next year.

Sixteen rats were induced spinal cord ischemia during the study, and then they were injected with with human spinal stem cells 21 days after paralysis. The researchers also injected seven other rats with with medium that did not contain stem cells.

They found that three of the nine rats injected with hSSCs returned to walking at six weeks, and three others had improved mobility in all lower extremity joints. All nine animals achieved significantly better motor scores than those in the control group, and showed a consistent presence of transplanted cells in the spinal area.

It was also seen that the majority of transplanted human spinal stem cells survived, and became mature neurons, according to Marsala. The researcher revealed that a second study conducted over a three-month period also furnished similar results.

The researchers believe that the therapy may eventually prove even more effective in human patients.

"Physical therapy may accelerate integration of the grafted stem cells and enhance their therapeutic be nefit," said co-author Karl Johe, a researcher at Neuralstem, the company that manufactures the hSSCs used in the study.

The researchers say that their main goal is to provide a significant gain in functional mobility of the patients legs.

"These research findings could offer great hope to people with spinal ischemic injury who suffer from resulting spasticity and rigidity," said Marsala.


Related medicine news :

1. Human Genome Project Achieves Technological Triumph
2. First Vaccine Designed for Africa Cleared for Testing in Humans
3. Human gene number increases
4. Scientists found ancient Human Germ Killer
5. New standards for Human Research Safety
6. Human wasting disease linked to a gene
7. The Human Mad Cow Case
8. Human Growth Hormone Found To be Dangerous For Human Use
9. Human Antibody That Can Block SARS
10. Human immunity system can battle HIV.
11. Two New Human Papilloma virus (HPV) vaccines to prevent cervical cancer
Post Your Comments:

(Date:11/28/2015)... ... November 28, 2015 , ... Safe storage for contraceptive devices ... inventors, one from Lakewood, New Jersey and the other from Bradley Beach, New Jersey, ... to save the expense of having to replace NuvaRings more often than necessary. As ...
(Date:11/27/2015)... ... November 28, 2015 , ... There is only one major question facing ... last year? , This question has not been an easy question to answer. Especially ... age and the younger workforce don’t share the same discipline around working long hours. ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... the health care in America. As people age, more care is needed, especially ... are rising, and medical professionals are being overworked. The forgotten part of this ...
(Date:11/27/2015)... Orange County, CA (PRWEB) , ... November 27, 2015 , ... ... holiday season , The company is offering customers 10% off of their purchase of ... purchase any treatment at full price. According to a company spokesperson. “Finding lice is ...
(Date:11/27/2015)... ... November 27, 2015 , ... Consistent with the Radiology ... Building Better Radiology Marketing Programs meeting will showcase some of the best ... at Caesars Palace in Las Vegas with a pre-conference session on a collaborative ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... PUNE, India , November ... --> ... / personal emergency response system ... grow steadily for 5 years ... growing region expected to see ...
(Date:11/26/2015)... Netherlands , November 26, 2015 ... A new combination approach blends immunotherapy with Bremachlorin-photodynamic ... A new combination approach blends immunotherapy with Bremachlorin-photodynamic therapy ... A new combination approach blends immunotherapy with Bremachlorin-photodynamic therapy ... Netherlands has found that immunotherapy can be ...
(Date:11/26/2015)... Research and Markets ( ) has announced the addition ... 2019 - Rise in Cardiac Disorders and Growing Awareness among ... offering. Boston scientific and ... and others. --> The market is dominated ... scientific and others. Asia ...
Breaking Medicine Technology: