Navigation Links
Human Membranes Crystal Structure may Help Tailor Asthma Drugs

Scientists have managed to reveal the crystal structure of a human membrane protein, LTC4 synthase, which has a major influence on the development of asthma .

LTC4 synthase is tremendously difficult to analyse, and previously only low-resolution information has been available on two membrane protein structures from human.

Now, researchers at Karolinska Institutet in Sweden believe that their work will facilitate the development of new and better therapeutics against inflammations in the pulmonary tract.

Asthma attacks are caused by a severe inflammatory reaction in the airways, a reaction that is largely due to actions of LTC4 synthase. For this reason asthma medicines often aim at blocking the downstream effects of LTC4 synthase.

However, there is a need for new pharmaceutical alternatives, as not all patients respond to the existing medicines.

Now, scientists at the Department of Medical Biochemistry and Biophysics have, with the help of the two EU networks Eicosanox and E-Mep, elucidated the three dimensional structure of the LTC4 synthase at 2.0 resolution.

It is clear from the structure that the protein has three identical subunits, each of them consisting of four spiral structures that cover the nuclear membrane.

Also the exact position and characteristics of the active sites, where activating or blocking molecules can attach, have been identified. With this knowledge it is now achievable to shape new molecules that can block the LTC4 synthase.

The new results are also very important as they can lead the way for the development of new and more effective therapeutics against other diseases.

Some 40 percent of the proteins of interest for pharmaceutical developments are membrane proteins. The current study is likely to lead the way for the determination of structures of other human m embrane proteins.


'"/>




Related medicine news :

1. Human Genome Project Achieves Technological Triumph
2. First Vaccine Designed for Africa Cleared for Testing in Humans
3. Human gene number increases
4. Scientists found ancient Human Germ Killer
5. New standards for Human Research Safety
6. Human wasting disease linked to a gene
7. The Human Mad Cow Case
8. Human Growth Hormone Found To be Dangerous For Human Use
9. Human Antibody That Can Block SARS
10. Human immunity system can battle HIV.
11. Two New Human Papilloma virus (HPV) vaccines to prevent cervical cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/18/2017)... ... January 18, 2017 , ... Park ... financial planning services to families and business owners in the greater Kansas City ... children with developmental disabilities. , The Lakemary Center is a comprehensive educational resource ...
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... ... communications company, launched a new website for its Center for Biosimilars, announced Michael ... include the latest developments in the field of biosimilars through thought leader interaction ...
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... Floundering on ... Heart Month and the perfect time for a reset. The U.S. Apple Association agrees ... to combat many of the factors that contribute to heart disease. , The U.S. ...
(Date:1/17/2017)... ... January 17, 2017 , ... In the crowded Ath-leisure market, ... stand-out company for several differences from other mainstream brands. , Firstly, in ... is called 'Agile' manufacturing - http://www.leanproduction.com/agile-manufacturing.html . It allows them to have ...
(Date:1/17/2017)... ... 2017 , ... SunView Software’s Service Smart Technology has been selected as a ... , Each year, Pink Elephant recognizes a new product or service developed by an ... problem or opportunity. The award highlights original innovations that were released in 2016, either ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... and KANSAS CITY, Mo. ... Neonatal Consortium (CHNC) has selected Velos and its ... data management and multicenter initiatives. CHNC ... of 32 Neonatal Intensive Care Units at leading ... . The consortium provides a benchmark of care ...
(Date:1/17/2017)... Following an initial analysis, the Senior ... and Drug Administration,s (FDA,s) final regulatory guidance regarding ... Pharmacies and Outsourcing Facilities." In its final guidance, ... -- which would have put patients at risk ... care (LTC) pharmacies.  The agency ...
(Date:1/17/2017)... a letter to President-elect Donald J. Trump , ... priorities for Americans age 50 and older including protecting ... care coverage, and lowering the cost of prescription drugs. ... Trump that "Our nearly 38 million members nationwide and ... their Medicare and Social Security benefits, protect their access ...
Breaking Medicine Technology: