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Human Embryonic Stem Cells Could Be Later Used In Therapeutic Cloning

d 14 human embryonic stem cell lines from diverse ethnic origins, derived in several different labs, and maintained for various times in culture. They tested over 1500 potential methylation sites in the DNA of these cells and in other cell types and found that the embryonic stem cells shared essentially identical methylation patterns in a large number of gene regions.

Furthermore, these methylation patterns were distinct from those in adult stem cells, differentiated cells, and cancer cells. ‘Our results suggest that therapeutic cloning of patient-specific human embryonic stem cells will be an enormous challenge, as nuclei from adult cells will have to be epigenetically reprogrammed to reflect the specific DNA methylation signature of normal human embryonic stem cells,’ explains Dr. Jeanne Loring, co-director of the stem cell center at BIMR. ‘This reinforces the need for basic research directed at understanding the fundamental biology of human embryonic stem cells before therapeutic uses can be considered.’

Source: Eurealert
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