Navigation Links
Human Embryonic Stem Cells Could Be Later Used In Therapeutic Cloning

according to the research conducted by the stem cells researchers across the world and researchers from the Burnham Institute //for Medical Research (BIMR)and Illumina Inc., it was found that embryonic stem cell research has inherent characteristics which make it pluripotent and totipotent.

This sets aside the embryonic stem cell from that of the other normal adult cells. These characteristics could be later used to replace diseased or damaged cells with healthy cells. The study results were published in the journal Genome Research. Embryonic stem cells are derived from embryos that are undergoing a period of intense cellular activity, including the chemical addition of methyl groups to specific DNA sequences in a process known as DNA methylation.

The methylation and demethylation of particular DNA sequences in the genome are known to have profound effects on cellular behavior and differentiation. For example, DNA methylation is one of the critical epigenetic events leading to the inactivation of one X chromosome in female cells. Failure to establish a normal pattern of DNA methylation during embryogenesis can cause immunological deficiencies, mental retardation and other abnormalities such as Rett, Prader-Willi, Angelman and Beckwith-Wiedemann syndromes. Until recently, DNA methylation could only be studied one gene at a time. But a new microarray-based technique developed at Illumina enabled the scientists conducting this new study to simultaneously examine hundreds of potential methylation sites, thereby revealing global patterns.

‘Analyzing the DNA methylation pattern of hundreds of genes at a time opens a new window for epigenetic research,’ says Dr. Jian-Bing Fan, director of molecular biology at Illumina. ‘Exciting insights into development, aging, and cancer should come quickly from understanding global patterns of DNA methylation.’To examine global DNA methylation patterns in human embryonic stem cells, the researchers analyze d 14 human embryonic stem cell lines from diverse ethnic origins, derived in several different labs, and maintained for various times in culture. They tested over 1500 potential methylation sites in the DNA of these cells and in other cell types and found that the embryonic stem cells shared essentially identical methylation patterns in a large number of gene regions.

Furthermore, these methylation patterns were distinct from those in adult stem cells, differentiated cells, and cancer cells. ‘Our results suggest that therapeutic cloning of patient-specific human embryonic stem cells will be an enormous challenge, as nuclei from adult cells will have to be epigenetically reprogrammed to reflect the specific DNA methylation signature of normal human embryonic stem cells,’ explains Dr. Jeanne Loring, co-director of the stem cell center at BIMR. ‘This reinforces the need for basic research directed at understanding the fundamental biology of human embryonic stem cells before therapeutic uses can be considered.’

Source: Eurealert

Related medicine news :

1. Human Genome Project Achieves Technological Triumph
2. First Vaccine Designed for Africa Cleared for Testing in Humans
3. Human gene number increases
4. Scientists found ancient Human Germ Killer
5. New standards for Human Research Safety
6. Human wasting disease linked to a gene
7. The Human Mad Cow Case
8. Human Growth Hormone Found To be Dangerous For Human Use
9. Human Antibody That Can Block SARS
10. Human immunity system can battle HIV.
11. Two New Human Papilloma virus (HPV) vaccines to prevent cervical cancer
Post Your Comments:

(Date:11/27/2015)... ... November 28, 2015 , ... There is only one major ... billings from last year? , This question has not been an easy question to ... the retirement age and the younger workforce don’t share the same discipline around working ...
(Date:11/27/2015)... ... November 27, 2015 , ... A team of Swiss doctors has released a ... Mesothelioma has just posted the findings on the website. Click here to read ... of 136 mesothelioma patients who were treated with chemotherapy followed by EPP surgery. Among ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ProSidebar: Fashion ... Final Cut Pro X. With ProSidebar: Fasion, video editors can easily add an ... as a minimalist title opener. Utilize presets featuring self-animating drop zones, lines, bars, ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... failing. Secura Consultants has prided itself for not only fulfilling the needs of ... protection solutions at an affordable price and providing top-tier customer service. However, there's ...
(Date:11/27/2015)... ... November 27, 2015 , ... Avid collector, Andrew Hawley from Vintage Rock ... concert posters. This is one of Joplin's most famous and beautiful concert posters. The ... of Michigan in Ann Arbor. The According to Hawley, "It is hard to believe ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 2015 --> --> ... to find optimal contrast weighting of MRI for patients ... signed a research agreement with SyntheticMR in order to use ... it is possible to generate multiple contrast images from a ... has left, thus making it possible to both fine tune ...
(Date:11/26/2015)... November 26, 2015 ... the "2016 Future Horizons and Growth ... Testing Market: Supplier Shares, Country Segment Forecasts, ... their offering. --> ) ... "2016 Future Horizons and Growth Strategies in ...
(Date:11/26/2015)... Nov. 26, 2015 Research and Markets ( ... "Advanced Wound Care Market by Type (Dressings, Therapy Devices, ... (In-Patient Facility, Out-Patient Facility), and Geography - Global Forecast ... --> --> The purpose ... and forecast of the global advanced wound care market. ...
Breaking Medicine Technology: