( ng number of disease-causing mutations....)Human Complexity Can Be Attributed To Regulatory Sequence,Health

ng number of disease-causing mutations. In Miano's study, the regulatory sequence under examination was the CArG box. Any sequence of code starting with 2 Cs, followed by any combination of 6 As or Ts, and ending in 2 Gs is a CArG box. There are 1,216 variations of CArG box. These associate with the nuclear factor called serum response factor (SRF) and several other proteins within a genetic regulatory network.

The current study is done to identify all CArG boxes that regulate genes. These studies use high-powered computer programs to screen data. A functional CArG box lies very closely to the genes that they regulate (within 4,000 base pairs). The researcher’s versions of these CArG boxes are put together to be called as CarGome.

Researchers also make use of comparative genomics to study the relationships between the DNA of different species. CArG boxes identified by the computer screen were then tested to see if they interacted with SRF and changed the behavior of genes as predicted. The study disclosed 60 CArG boxes to exert an influence over a gene.

Of the newly found genes of CArG-SRF, more than half encode for cytoskeletal or contractile proteins. Previous study also confirms this idea. As it is present in all the cells and throughout the human genome, the CArG-SRF system is believed to contribute to disease in many bodily tissues. A lack of SRF-CArG causes cardiomyopathy, a weakening of heart muscle cells' ability to contract which leads to heart failure.

CArG sequences is also found near the genes that direct the building of nerve cells and blood vessels, suggesting they may be involved in diseases affecting those tissues as well. The answer to the degree of human complexity is that of the Regulatory sequences. It enables a single gene to produce the same protein at different times, places and concentrations with subtly different roles.


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