archers transplanted these human cells into mice, the cells effectively incorporated in a variety of brain regions.
The human cells were acquired from patients who had undergone surgical treatment for epilepsy and were extracted from support tissue within the gray matter, which is not known for harboring stem cells.
When the donor cells were subjected to a bath of growth agents within cell cultures, a type of cell emerged that behaves like something called a neural progenitor - a cell that is a bit further along in development than a stem cell but shares a stem cell's vaunted ability to divide and transform into different types of brain cells.
Even when the cells from the epilepsy patients were transplanted into mice, bypassing any growth enhancements, they were able to take cues from their surroundings and produce new neurons.
"It was a long and difficult process, but we were able to induce what are basically support cells in the human brain to form beautiful new neurons in a dish," said Noah Walton, a graduate student in the neuroscience department at the UF College of Medicine. "But what we really needed is for these support cells to turn into neurons in the brain, and we found we could get them to do it. Something in the environment in the rodent brain is sufficient to get these cells to become neurons."
Scientists speculate a small amount of existing progenitors may be emerging from the gray matter of the brain and multiplying in torrents, or perhaps the aging clock of the mature cells actually turns backward when the donor cells are in a new environment, returning them to past lives as progenitors or as stem cells.
"It's been shown that the same sorts of tissue from the mouse brain can give rise to rapidly dividing cells, but this shows it is true with human cells," said Ben Barres, M.D., Ph.D., a professor of neurobiology at the Stanford University School of Medicine whoPage: 1 2 3 Related medicine news :1
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