Navigation Links
How to Hinder Gene Amplification? - Researchers Revealed

Scientists at the Georgia Institute of Technology have discovered a process by which gene amplification could be stopped in fatal-disease conditions //like tumour growth and cancer.

Using yeast as a model organism, researchers have found that the location of a hairpin-capped break relative to the end of the chromosome will determine the fate of the amplification process.

Gene amplification is the increase in copy number of a particular piece of DNA and is a hallmark of tumor cells. Amplified genomic segments are frequently manifested in one of two cytologically recognizable forms. Double minutes are extrachromosomal segments of amplified DNA. Homogeneously staining regions are amplified intrachromosomal segments forming large genomic regions. Some strategies of pharmaceutical research in cancer prevention and treatment could involve curbing cancer development via restricting gene amplification. The first step towards achieving this is to discover the rules that govern whether an amplification event is a double minute or a homogenously-staining region.

It’s known that regions of chromosomes that are prone to amplification have palindromic sequences of DNA, which are weak places where the chromosome can break. These palindromic sequences can be naturally found in human genome. The distribution of such sequences can vary from one individual to another. Researchers at the Georgia Institute of Technology have discovered that a particular type of DNA break, a hairpin-capped double strand break, induced by these palindromic sequences, is a precursor to amplification.

‘We have a developed a system in yeast which would mimic the situation in human cancer cells wherein oncogenes might be located next to palindromic sequences. Using this system we have discovered the rules that determine how double minutes or homogeneously staining regions can be generated,’ said Kirill Lobachev, assistant professor in Georgia Tech’s School of Bio logy.

‘If these rules operating in yeast can be extended to higher eukaryotes then we can propose that if the oncogene is located between the hairpin-capped break and the telomere, then the amplification event will result in a double minute. If the break occurs between the oncogene and the telomere, then the amplification would yield a homogenously-staining region.’ adds Vidhya Narayanan a Ph.D. student in Kirill Lobachev’s lab and first author of the study.

The findings can help researchers understand the cause of cancer in diseased individuals and also to potentially identify individuals who might be prone for cancer.

In addition to Lobachev and Narayanan, the research team consisted of Hyun-Min Kim from Georgia Tech and collaborators Piotr A. Mieczkowski and Thomas D. Petes from Duke University. This work was supported by funds from National Science Foundation and National Institute of Health.

Source: Eureklert
'"/>




Related medicine news :

1. Archaic Law Hindering HIV Prevention In Namibian Prisons
2. ‘Family Honour’ Hinder Pakistani Girls In Getting Educatin
3. Obesity Hinders Medical Diagnostic Tests
4. Common Sleep Disorder Hinders School Performance
5. Smoking Hinders Pregnancy
6. Fear of Possible Harm Hinder Nanotech Development
7. Popular Herbal Supplement Hinders the Growth of Pancreatic Cancer Cells
8. Researchers urge caution in using ear tube surgery
9. Researchers Scale to assess the Severity of Epilepsy in Kids
10. Researchers trick Alzheimers Enzyme
11. Researchers find new HIV hiding place
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... (PRWEB) , ... June 27, 2016 , ... Quality metrics ... yet in many ways they remain in the eye of the beholder, according to ... a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... , ... June 26, 2016 , ... PawPaws brand ... new product that was developed to enhance the health of felines. The formula is ... The two main herbs in the PawPaws Cat Kidney Support Supplement Soft ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... OAKLAND, N.J. , June 24, 2016 /PRNewswire/ ... in the design, development and manufacturing of collagen ... and regeneration announced today that Bill Messer ... Sales and Marketing to further leverage the growing ... surgery medical devices. Bill joins the ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... addition of the "Structural Electronics 2015-2025: Applications, ... In-Mold Electronics, Smart ... Integrated Photovoltaics Structural electronics involves ... as load-bearing, protective structures, replacing dumb structures such ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
Breaking Medicine Technology: