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How Plague-Causing Bacteria Disarm Host Defense

whats commonly known as food poisoning. All three bacteria species find their way past the bodys immune system through a sophisticated invasion system that injects the effector proteins directly into the host cells cytoplasm.

More than a decade after its discovery, our understanding of YpkA is still incomplete, Navarro said. But Yersinia has maintained YpkA over millions of years, so it must be doing something important. The researchers speculate that YpkA plays an important role in disabling the bodys immune system beyond its previously known role of disrupting the host cells normal structure, which interferes with the cells innate ability to engulf and destroy invading bacteria. The question now becomes, why is Gq targeted by YpkA?


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