Navigation Links
How Plague-Causing Bacteria Disarm Host Defense

Effector proteins are the bad guys that help bacterial pathogens do their job of infecting the host by crippling the bodys immune system. In essence, they knock down the front door of resistance and disarm the cells alarm system.

Now, researchers at the University of California, San Diego (UCSD) School of Medicine have identified a novel molecular target for an effector protein called YpkA, one of several effectors of the bacteria Yersinia the pathogen responsible for the Middle Ages Black Death and a virulent form of food poisoning today. Their study will be published online in the May 25 issue of Molecular Cell.

YpkA targets a host protein called Gq, the messenger that transmits extracellular signals (we are under attack!) into the host cell, so that it can mount a defense.

The alarm signal sent by Gq is intercepted by YpkA, which sets up a roadblock along several cellular pathways that Gq uses to deliver the alarm, said lead author Lorena Navarro, Ph.D., post-doctoral researcher in the lab of the studys principle investigator, Jack E. Dixon, Ph.D., professor of Pharmacology and Cellular and Molecular Medicine at the UCSD School of Medicine.

Identifying this new target is the first step to developing effective strategies for preventing disease, including means to fight antibiotic-resistant strains of Yersinia that could be used in biological warfare, according to Navarro.

The genus Yersinia includes three species of bacteria that are pathogenic to humans: Y. pestis is perhaps the most infamous, being responsible for the bubonic plague (also known as the Black Death), which killed more than 200 million people in the Middle Ages.

This bacterial species could still be a threat today, said Navarro, adding that scientists had isolated an antibiotic-resistant strain of this species. In addition Y. pseudotuberculosis and Y. enterocolitica are big words for nasty, little bugs that cause
'"/>




Page: 1 2

Related medicine news :

1. Bacterial discovery may help CF patients
2. Cure for Bacterial Meningitis
3. Before Weight Loss Surgery One Should Get Tested for Bacteria
4. Molecule That Aids Bacterial Infections Identified
5. Moms Stomach Bacteria Can Cause Leukaemia In Children
6. Bacteria Evolve Armamentarium Against Antibiotics By ‘Stealing’ Gens
7. Bacterial Photographs Created By Student Scientists!
8. Bacterial infestation in food very critical!
9. Tooth Decay Bacteria Unaffected By Altered Biochemical Pathway
10. Beneficial Symbiotic Relationship Between Ants And Bacteria.
11. Tamiflu substrate produced from Bioengineered Bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How Plague Causing Bacteria Disarm Host Defense

(Date:8/31/2015)... ... August 31, 2015 , ... The more hours young adults spend watching television ... and bigger waist circumference, a 15-year analysis by the University of Pittsburgh Graduate School ... years, indicating that young adulthood is an important time to intervene and promote less ...
(Date:8/31/2015)... San Fernando Valley, CA (PRWEB) , ... August 31, 2015 , ... ... Dr. Pedram Ghasri, to the practice. Dr. Pedram Ghasri is a graduate of the ... Science in neuroscience and continued his studies at the University of California, Irvine Medical ...
(Date:8/31/2015)... Village, IL (PRWEB) , ... August 31, 2015 , ... ... new studies, Etymotic Research, maker of the BEAN™ personal sound amplifier, is offering caregivers ... personal sound amplifiers as a way of coping with a variety of home healthcare ...
(Date:8/31/2015)... ... August 31, 2015 , ... For 12 years, since ... acknowledged September 26th as Mesothelioma Awareness Day . On this day, and in ... several ways of becoming involved and helping the cause. , “One of the ways ...
(Date:8/31/2015)... ... August 31, 2015 , ... MeYou Health ®, a ... mobile walking app, Walkadoo , by including an in-app step tracker. , ... to each person’s walking habits. Rather than broadly assign every Walkadoo member 10,000 steps ...
Breaking Medicine News(10 mins):Health News:Watching More TV as a Young Adult Predicts Obesity 2Health News:Watching More TV as a Young Adult Predicts Obesity 3Health News:Castle Dermatology Institute Now Welcomes Dr. Pedram Ghasri to the Practice 2Health News:Etymotic Offers Caregivers “7 Reasons to Care about Hearing Health” 2Health News:Etymotic Offers Caregivers “7 Reasons to Care about Hearing Health” 3Health News:Cancer Research Organization Paints the World in Mesothelioma Awareness 2Health News:Cancer Research Organization Paints the World in Mesothelioma Awareness 3Health News:Walkadoo™ Walking Program Now Includes In-app Step Tracker 2
... importance of effect , MONDAY, Oct. 5 (HealthDay News) ... blood pressure, this isn,t reason enough for most people to ... increase of blood pressure due to methylmercury will never outweigh ... a professor in the department of social and preventive medicine ...
... Projects that inoculating 40% of population in October, November ... -- To minimize deaths from the H1N1 pandemic swine ... new U.S. study suggests. , "Earlier -- October versus ... said the study,s lead researcher, Dr. Nayer Khazeni, from ...
... , Improved monitoring for progression of disease ... Pa., Oct. 5 An expert panel of nationally ... Foundation is calling for more consistent monitoring and referral ... (HBV). The panel,s recommendations for pediatricians and other primary ...
... 5 Scientists at Fred Hutchinson Cancer Research Center ... million under the American Recovery & Reinvestment Act of ... 1 and reported by the National Institutes of Health. ... million to $33,596 and benefit every level of researcher ...
... 2009 -- On 9 and 10 October the anniversary South ... Drama Theatre (Jugoslovensko Dramsko Pozoriste) in Belgrade (RS). Professor Michael ... European Association of Urology: "For the 5th time the SEEM ... from the region is presented to an international audience". ...
... ... patient safety culture and how are they measured? , ... Charlotte, N.C. (Vocus) October 5, 2009 -- Morehead, the human capital ... The free hour-long webinar will be broadcast on Tuesday, October 20, 2009 at 1:00 p.m. ...
Cached Medicine News:Health News:Mercury in Fish Linked to High Blood Pressure 2Health News:Mercury in Fish Linked to High Blood Pressure 3Health News:Early H1N1 Vaccination Saves Lives, Cuts Costs: Study 2Health News:Early H1N1 Vaccination Saves Lives, Cuts Costs: Study 3Health News:Expert Panel of Pediatric Liver Specialists Publishes Recommendations for Monitoring and Referral of Children With Chronic Hepatitis B Infections 2Health News:Expert Panel of Pediatric Liver Specialists Publishes Recommendations for Monitoring and Referral of Children With Chronic Hepatitis B Infections 3Health News:Federal Stimulus Funding Channels More Than $40 Million to Fred Hutchinson Cancer Research Center 2Health News:Federal Stimulus Funding Channels More Than $40 Million to Fred Hutchinson Cancer Research Center 3Health News:Federal Stimulus Funding Channels More Than $40 Million to Fred Hutchinson Cancer Research Center 4Health News:Morehead Presents Webinar on "Measuring the Organization's Patient Safety Culture" 2
(Date:8/31/2015)... ADELAIDE, Australia , Aug. 31, 2015 ... the discovery and development of innovative therapeutics for the ... and cancer, today announced that its BNC101 IND submission ... Administration (FDA). Bionomics plans to initiate a Phase 1 ... in patients with metastatic pancreatic cancer prior to 31 ...
(Date:8/30/2015)... 30, 2015 La solución ... l cuidado al paciente a ... Royal Philips  (NYSE: PHG, AEX: ... IntelliSpace Cardiovascular , un sistema web de gestión de ... analizar y compartir imágenes cardiovasculares e información en cualquier ...
(Date:8/28/2015)... Calif. , Aug. 28, 2015  CytomX Therapeutics, ... treatment of cancer, today announced the filing of a ... and Exchange Commission (SEC) relating to a proposed initial ... shares to be offered and the price range for ... to list its common stock under the symbol "CTMX" ...
Breaking Medicine Technology:Successful BNC101 IND Submission Paves Way for Development of Promising Cancer Stem Cell Drug Candidate 2Successful BNC101 IND Submission Paves Way for Development of Promising Cancer Stem Cell Drug Candidate 3Successful BNC101 IND Submission Paves Way for Development of Promising Cancer Stem Cell Drug Candidate 4Philips presenta IntelliSpace Cardiovascular en el Congreso ESC 2015 2Philips presenta IntelliSpace Cardiovascular en el Congreso ESC 2015 3CytomX Files Registration Statement for Proposed Initial Public Offering 2
... from HealthTronics is a ... versatile urology table available ... forward in design and ... by urologists, the UroVantage ...
... DR Urology System provides a revolutionary approach ... dedicated digital urology imaging system ever developed. ... to use optimized geometry and a large ... maximum anatomical coverage and sharper images yielding ...
... therapeutic, expandable turning surface for the BariMaxx™ ... Prevention and treatment of pressure ulcers, Large ... patients using a statuc mattress that would ... whose body weight and size pose a ...
... BariMaxx™ II is a full-featured healthcare bed ... for the care and management of ... up to 1000 lbs. ,Large patients at ... daily weight monitoring, ,CONTRAINDICATION: ,Total weight ...
Medicine Products: