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How Many Genes Does It Take to Learn? Lessons from Sea Slugs

s. If we are going to understand memory or neurological disease at the cellular level, we need to understand the rules."

Scientists also analyzed 146 human genes implicated in 168 neurological disorders, including Parkinson's and Alzheimer's diseases, and genes controlling aging and stem-cell differentiation. They found 104 counterpart genes in Aplysia, suggesting it will be a valuable tool for developing treatments for neurodegenerative diseases.

"The authors have assembled a tremendous amount of data on gene transcripts associated with neuronal signaling pathways in Aplysia that sheds new light on evolutionary relationships of this very ancient and highly successful marine animal," said Dennis Steindler, Ph.D., executive director of UF's McKnight Brain Institute, who did not participate in the research. "A very important part of this study is the discovery of novel genes not formerly associated with the mollusk genome that include many associated with neurological disorders."

The findings are especially important for scientists using mollusks in experimental systems, according to Edgar Walters, Ph.D., a professor of integrative biology and pharmacology at the University of Texas Medical School at Houston, who was not involved in the research.

"Few animals other than Aplysia allow scientists to relate a molecular pathway directly to the function of a cell, all in context with an animal's behavior," Walters said. "In a mammal, it's hard to identify and manipulate a single cell and know what its function is. With Aplysia, there is direct access to whatever cell you're interested in with just a micropipette. As a scientist who wants to know which molecules are present in Aplysia for experimental manipulation, I am very happy to see this paper come out."

Source-Eurekalert
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