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How Does Leptin Work?

Leptin is a wonder hormone which is discovered around 1994 which has the ability to perform multi tasks such as to controls appetite, burns calories// and performs other crucial physiological activities.

But the actual mechanism or mode of action through which Leptin carries out these metabolic activities were not known till date. Now, researchers at the Albert Einstein College of Medicine of Yeshiva University have identifies the mode in which Leptin carries out its functions. The study results are published in the journal Cell Metabolism. Fat cells release Leptin into the bloodstream. The hypothalamus ‘reads’ the amount of circulating Leptin and uses this information to regulate appetite, metabolism and other processes.

‘Leptin is known to bind to cell-surface receptors in the hypothalamus and then to activate various other cellular signals including a molecule called STAT3--but the role of STAT3 in mediating leptin's multiple physiological effects was still unknown,’ says Dr. Luciano Rossetti, the study's senior author and the director of the Diabetes Research and Training Center at Einstein. To learn whether STAT3 mediates some of leptin's activities, ‘we devised a technique for inactivating STAT3 with pinpoint accuracy in the hypothalamus and observing the results in laboratory animals when we administered Leptin,’ says Dr. Rossetti.

‘Our tool for rapidly inactivating STAT3 was a cell-permeable peptide (short protein) that we infused into specific areas of the hypothalamus using fine needles. This technique can serve as a model for investigating all types of signaling pathways in selective regions of the brain.’ The researchers found that STAT3 production is essential for leptin's best-known action: acutely reducing food intake. Since obesity occurs when people become resistant to leptin's ‘curb your eating’ message, this finding suggests that bypassing Leptin and directly activating STAT3 may allow one to normalize appetite an
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