Navigation Links
How Does Leptin Work?

Leptin is a wonder hormone which is discovered around 1994 which has the ability to perform multi tasks such as to controls appetite, burns calories// and performs other crucial physiological activities.

But the actual mechanism or mode of action through which Leptin carries out these metabolic activities were not known till date. Now, researchers at the Albert Einstein College of Medicine of Yeshiva University have identifies the mode in which Leptin carries out its functions. The study results are published in the journal Cell Metabolism. Fat cells release Leptin into the bloodstream. The hypothalamus ‘reads’ the amount of circulating Leptin and uses this information to regulate appetite, metabolism and other processes.

‘Leptin is known to bind to cell-surface receptors in the hypothalamus and then to activate various other cellular signals including a molecule called STAT3--but the role of STAT3 in mediating leptin's multiple physiological effects was still unknown,’ says Dr. Luciano Rossetti, the study's senior author and the director of the Diabetes Research and Training Center at Einstein. To learn whether STAT3 mediates some of leptin's activities, ‘we devised a technique for inactivating STAT3 with pinpoint accuracy in the hypothalamus and observing the results in laboratory animals when we administered Leptin,’ says Dr. Rossetti.

‘Our tool for rapidly inactivating STAT3 was a cell-permeable peptide (short protein) that we infused into specific areas of the hypothalamus using fine needles. This technique can serve as a model for investigating all types of signaling pathways in selective regions of the brain.’ The researchers found that STAT3 production is essential for leptin's best-known action: acutely reducing food intake. Since obesity occurs when people become resistant to leptin's ‘curb your eating’ message, this finding suggests that bypassing Leptin and directly activating STAT3 may allow one to normalize appetite an d produce other health benefits as well.

As it does with appetite, Leptin also influences glucose metabolism. Aberrant glucose metabolism causes the hypergylcemia (high blood-sugar levels) that is the hallmark of diabetes. ‘There had been considerable controversy as to whether Leptin controls glucose metabolism through STAT3 production or not,’ says Dr. Rossetti. ‘Using our technique for blocking STAT3, we were able to show that STAT3 is absolutely necessary for the acute effect of Leptin on glucose metabolism.’ Leptin is also known to influence fertility. Women with very little body fat--elite female athletes, for example--may stop menstruating and experience temporary infertility. This is largely due to inadequate secretion of leutenizing hormone and follicle stimulating hormone by the pituitary gland--which in turn is caused by the near-disappearance of Leptin from the bloodstream.

A recent study showed that low doses of Leptin can restore the menstrual cycle in such women. Using their STAT3-blocking technique, the Einstein researchers showed that this acute effect of Leptin depends on the activation of STAT3. ‘This work has shown that STAT3 is fundamentally important for expressing several of leptin's acute effects,’ says Dr. Rossetti. ‘Since we now fully appreciate the important role of STAT3 in leptin's metabolic actions, strategies designed to restore the effects of Leptin on STAT3 should achieve considerable health benefits. An obvious target is obesity, where the big problem is Leptin resistance. But in addition, our findings suggest that selectively turning on STAT3 may help prevent diabetes by improving glucose metabolism and help restore fertility as ell.’


Related medicine news :

1. Leptin connected to obesity blood clots
2. Leptin linked to Blood Clots
3. Weight gain following smoking cessation not linked to Leptin
4. Leptin is "new breast cancer indicator"
5. Hormone Leptin Found To Be Effective In Treating Women With Infertility Problems
6. Scientists crack mechanism of Leptin-Obesity Hormone
7. Obesity Hormone - Leptin may treat Metabolic Disorder
8. Leptin and inflammatory cytokines in women with pre-eclampsia
9. Leptin Hormone Plays Key Role In Losing Weight
10. Leptin Injections Maintain Loss In Body Weight
11. Leptin, The Next Generation Antidepressant?
Post Your Comments:

(Date:11/28/2015)... PA (PRWEB) , ... November 28, 2015 , ... Safe ... the creativity of two inventors, one from Lakewood, New Jersey and the other from ... developed the patent-pending PROTECTOR to save the expense of having to replace NuvaRings more ...
(Date:11/27/2015)... ... November 27, 2015 , ... According to an article published November ... meeting in Washington D.C. revolved around the fact that proper dental care, both at-home ... stressed the link between periodontal disease (more commonly referred to as gum disease) and ...
(Date:11/27/2015)... ... November 27, 2015 , ... An ... way to dispense prescription medications at home, so he invented the patent-pending ELECTRONIC ... and dispense prescription medications. In doing so, it could help to prevent potential ...
(Date:11/27/2015)... ... , ... MPWH, the No.1 Herpes-only dating community in the world, revealed that over 50% of ... than 3.7 billion people under the age of 50 – or 67% of the population ... global estimates of HSV-1 infection . , "The data shocks us highly!" said Michelle ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... innovative online platform for mental health and wellness consultation, has collaborated with a ... will bridge the knowledge gap experienced by parents and bring advice from parenting ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... Nov. 27, 2015  Lannett Company, Inc. (NYSE: ... completed the acquisition of Kremers Urban Pharmaceuticals Inc. ... global biopharmaceuticals company UCB S.A. (Euronext: UCB). ... has acquired KU from UCB for total consideration ... including a customary working capital adjustment, a deduction ...
(Date:11/26/2015)... UTRECHT , Países Bajos, November 26, 2015 /PRNewswire/ ... con la terapia fotodinámica de Bremachlorin para el cáncer ... combina la inmunoterapia con la terapia fotodinámica de Bremachlorin ... Un nuevo enfoque combina la inmunoterapia con la ...   Clinical Cancer Research . --> ...
(Date:11/26/2015)... --> --> ... find optimal contrast weighting of MRI for patients with ... a research agreement with SyntheticMR in order to use SyMRI ... is possible to generate multiple contrast images from a single ... left, thus making it possible to both fine tune images ...
Breaking Medicine Technology: