Navigation Links
How Bloods Vessels are Linked Together?

The Scientists at Karolinska Institutet have discovered a heretofore-unknown mechanism for -how the body links together its blood vessels.//

New blood vessels are formed when a "shoot" sprouts from an already existing vessel. These shoots lengthen, branch off and contact other vessels as they form communicating networks of channels. The process is called "angiogenesis" and is important in foetal development and normal tissue formation in connection with the healing of wounds, the menstrual cycle and so on. However, it also plays a critical part in morbid tissue formation, such as cancer and chronic inflammatory diseases.

The inhibition of morbid angiogenesis therefore has very attractive therapeutic potential for a variety of diseases. Tumours, for instance, can grow no larger than 1 or 2 mm without new blood vessels, upon which they are dependent for their proliferation. To date, anti-angiogenic therapy has proved effective in the treatment of colon cancer and the common eye disease AMD (Age-dependent Macula Degeneration).

All therapies have so far targeted the growth factor VEGF (Vascular Endothelial Growth Factor). VEGF controls several important functions during the formation of blood vessels by signaling via receptors on the surface of the endothelial cells, the specialised layer of cells on the interior surface of the blood vessels.

Swedish scientists at Karolinska Institutet and the biotech company AngioGenetics AB have now shown that another factor called Dll4 (Delta-like 4) has a similarly fundamental role in blood vessel formation as VEGF. The results are published in Nature no. 28 (January 2007) and can mean that Dll4 is just as important a target for anti-angiogenic drugs as VEGF.

"We can now develop ways of boosting the effect of existing anti-angiogenic therapies, and maybe we can even start to treat tumour types that do not currently respond to anti-angiogenic drugs," says Mats Hellstr?m, one of the scientists involved in the study.

The researchers have found that Dll4 signalling determines how many sprouts bud off from the parent vessel. This principle is critical to the number of branches and links that form and to attaining the correct density of vessels. Too great a blood supply to a tissue is just as devastating as too little.


Related medicine news :

1. All Intravascular Devices Pose Risk of Bloodstream Infection to Patients
2. Simple Steps to Safe Guard Patients from Bloodstream Infections in ICU
3. Simple Steps to Safe Guard Patients from Bloodstream Infections in ICU
4. Sugars in Liver Found to Clear Fats from the Bloodstream
5. Chemical in Vegetables Keep Blood Vessels Healthy
6. Chemical in Vegetables Keep Blood Vessels Healthy
7. Cancer Cells Forming Blood Vessels Send Their Copper to the Edge
8. Low Cholesterol Linked to Severe Depression and Violent Behavior in Men
9. Cough Syrup Ingredient Linked to Stroke
10. Irregular Periods Linked to Diabetes
11. Hormones Linked To Migraines
Post Your Comments:

(Date:11/30/2015)... , ... December 01, 2015 , ... The Turks & ... one of the leading digital news sites highlighting Caribbean destinations, has published five reasons ... While much of North America shivers under chilly grey skies or worse, it's typically ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... Bi-National Convention of the Federation of Philippine American Chambers of Commerce held from ... Nevada. , 1Heart Caregiver Services, as an active delegate from the Philippine ...
(Date:11/30/2015)... ... 2015 , ... During the National Family Caregivers Month, the ... webinars on topics of ‘Medical and Palliative Care Decisions,’ and ‘Self-Care for Caregivers.’ ... , With a loved one's diagnosis of mesothelioma, the closest family member is ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... . The directory is specialized and only includes chiropractic clinics in the US. ... competent and trustworthy alternative health practitioner when back pain sets in. When people ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... atmosphere for Halloween festivities, the Word of Life Christian Church of Flint, MI, ... and featuring a giant 1.25 ton pile of candy dubbed “Candy Mountain”. , ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... 1, 2015 ... of the  "2016 Shigella Testing Market: ... Competitive Strategies, Emerging Opportunities--US, Europe (France, ... to their offering. --> ... of the  "2016 Shigella Testing Market: ...
(Date:11/30/2015)... and BASEL, Switzerland , Dec. 1, ... (Upsher-Smith), through its wholly-owned UK subsidiary Proximagen Ltd., today ... a novel, oral small molecule inhibitor of Vascular Adhesion ... effective in the treatment of inflammatory disease. The VAP-1 ... --> --> Under the ...
(Date:11/30/2015)... 2015 MEDTEC Japon 2016, ... d,Asie portant sur la conception de ... se tiendra à Tokyo ... avril 2016. ... - Logo - ...
Breaking Medicine Technology: