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Hormone therapy may affect heart attack severity in women

amount of irreversible muscle damage that resulted after an experimentally produced heart attack. They found that the two progestins produced dramatically different results. The Femhrt group had 5 percent muscle damage, the group that didn't take hormone therapy had 20 percent damage, and the Prempro group had 35 percent damage.

The amount of heart muscle damage can affect risk of a future heart attack and risk of developing heart failure, the inability of the heart to meet the body's demands.

Williams said the results suggest that all hormone therapy drugs are not the same and that there may be better treatments than current formulations. He said, however, that the results are too preliminary to apply to women. The researches still have a long way to go. They want to learn how estrogen alone - without a progestin - will affect the amount of muscle damage, and what caused the differences in muscle damage. They suspect that it is related to the amount of inflammation that occurs after a heart attack. The group, wants to see how soy, which has anti-inflammatory properties, would affect muscle damage.

Other researchers were Irma Suparto, M.D., from the Institute Pertanian Bogor in Indonesia and Jacob Vinten-Johansen, Ph.D., a professor or surgery at Emory University.


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