Navigation Links
Hope for Patients With Kidney Failure

Kidney failure commonly occurs in intensive care units following a major surgery, and currently, patients who experience it have a mortality rate of about 50 percent and according to researchers it is one of the major causes of death in seriously ill patients. //

A recently discovered molecule may have the potential to protect the kidneys from failing after injury, according to new research.For the study, mice were genetically engineered to express higher-than-normal levels of the natural molecule hepatic growth factor (HGF) or another natural factor called parathyroid hormone-related protein (PTHrP). Both groups of mice developed normal kidney functions, thus allowing the researchers to study how the high levels of HGF and PTHrP would affect kidney recovery after blood flow to the kidney was temporarily interrupted.

Scientists found the mice that had not been genetically modified had their kidney functions sharply reduced, and the function worsened over time following the reduction in blood supply. In contrast, the mice with higher levels of HGF experienced a much lower degree of kidney damage after injury. Two days later, their kidney functions had almost completely returned to normal. Mice with high levels of HGF were also much more likely to survive after kidney injuries than mice with normal levels. When the researchers examined the kidneys of the genetically modified mice, they discovered the high level of HGF actually protected the renal tubule cells. These cells play an important role in the kidney's ability to produce urine.

Thus researchers say the fact that the kidneys developed normally in high-HGF and high-PTHrP mice is an important step forward in assessing the protective effects of these factors against cell damage. Researchers say it is remarkable that the HGF does not seem to negatively affect kidney development, yet it has a striking protective effect against kidney failure.

Based on the study researche rs conclude that gene delivery of HGF to the proximal tubule may be an interesting approach in designing future strategies aimed at the treatment and prevention of [acute renal failure].

Related medicine news :

1. One in Three Heart Attack Patients Have No Chest Pains
2. Amphetamines Help Recovery of Stroke Patients
3. Painkillers Do Not Shorten Dying Patients Lives
4. Patients With Filariasis More Prone To HIV Infection
5. Glivec - New Hope For CMC Patients
6. Patients often assume wrongly that they are allergic to penicillin
7. New FDA Approved Drug NATRECOR For Heart Failure Patients
8. Hemochromatosis Patients Blood is Safe
9. Patients Pressure Would Result In Overprescription
10. Risk Of Decongestants In Hypertensive Patients
11. Interference helps Heart Patients
Post Your Comments:

(Date:11/30/2015)... , ... November 30, 2015 , ... The world of ... harvesting and follicular unit extraction. These techniques and procedures have been in use for ... from hair loss. While Dr. Parsa Mohebi, M.D. has utilized many of these methods ...
(Date:11/30/2015)... Battle Creek, Michigan (PRWEB) , ... November 30, 2015 , ... ... Creek, MI, the American Cancer Society held an annual fundraising event, a 5K walk ... Recovery, a holistic treatment center for substance abuse which is also located in Battle ...
(Date:11/30/2015)... ... November 30, 2015 , ... The presidential race normally deals with political issues ... it a national news story when Donald Trump makes disparaging remarks about Hillary Clinton’s ... more than anyone wants to admit when it comes to how people are viewed ...
(Date:11/30/2015)... Angeles, CA (PRWEB) , ... November 30, 2015 , ... ... star Jessie James Decker made a brave but slightly unusual choice to show her ... returning to her pre-pregnancy form may have been pre-mature. Saying that she didn’t “want ...
(Date:11/30/2015)... ... ... According to Los Angeles bariatric surgeon Michael Feiz, M.D., F.A.C.S., many of ... hunger, but instead by a hormone called ghrelin which (often prematurely) signals to ... aware that weight loss surgery can help patients lose weight by restricting the capacity ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... --  Royal Philips  (NYSE: PHG ; AEX: ... a fully integrated, consultative approach to enhance radiology ... management approaches that combine imaging systems, services, informatics ... delivery and reduce costs. Making its debut at ... Annual Meeting (RSNA) in Chicago ...
(Date:11/30/2015)... CHICAGO , Nov. 30, 2015 Nautilus ... next-generation Radiology Image Management platform ( ). The ... was announced from RSNA 2015 (Radiology Society North America) ... Radiology conference in the U.S. --> ... radiology platform that enables access to radiology studies worldwide ...
(Date:11/30/2015)... (HK$,000)For the Six Months Ended 30 September 2015 2014RestatedChange%Turnover 545,575 , 518,852 ... , 384,242 , 9.8 Hospital ... , (18.3) Medical Insurance Administration Service Income , ... Medical Devices and Accessories Sales , 89,645 , ... , 2,822 , 2,917 , ...
Breaking Medicine Technology: