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Hope For Bedwetting Children

en to them, children rated bedwetting in the top 10, he said.

Rittig published a study in 1989 showing that the hormone vasopressin plays a role in enuresis. This research helped lead to the use of desmopressin to stop bedwetting in many enuretic children. But he and others have remained puzzled as to why some children do not respond to desmopressin. In this study, the researchers set out to understand the physiological mechanisms behind the 30% of desmopressin nonresponders.

24-hour study

The researchers examined 46 enuretic children, ages 7-14, who were outpatients at the Center for Child Incontinence at Aarhus University Hospital and whose enuresis had failed to respond to desmopressin. The enuretic children were subdivided into a “polyuric” group (average nocturnal output on wet nights exceeded 130% of expected bladder capacity) and nonpolyuric (output on wet nights less than 130% of expected capacity). The study also included an age-matched control group of 15 non-enuretic children.

The children spent two nights at Aarhus University Hospital. The first night was to acclimate the children to the hospital environment while the second night was the experimental period. The researchers collected blood and urine from the children during the second night, without waking them. This gave the researchers a more complete picture of physiological changes that occur through the course of an entire night.

Fluid and sodium intake was standardized for all children, based on their weight, to eliminate the possibility that enuretic episodes were related either to excess sodium or fluid intake. All children had adequate bladder capacity and were healthy. None experienced daytime incontinence.

Some enuretic children (five polyurics and four nonpolyurics) did not have a wet night during their stay. This is not unusual for enuretic children, many of whom get through some nights without an episode. The enu
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