Bedwetting is involuntary urination during sleep, and is a major problem for children and their parents.// Although 70% of children who suffer from bedwetting (nocturnal enuresis) respond to desmopressin, 30% do not.

Danish medical doctors have come up with a finding that nighttime urine of these children who do not respond to the common medication, show more sodium and urea.They say that this may possibly be due to an imbalance of prostaglandin, which is a hormone-like substance.

These doctors who treat enuresis, hope that this finding could help lead to better treatment for these children.

The study “Nocturnal polyuria in monosymptomatic nocturnal enuresis refractory to desmopressin treatment,” was carried out by Konstantinos Kamperis and Jens Christian Djurhuus of the University of Aarhus, Aarhus, Denmark and Soren Rittig and Kaj Anker Jorgensen of the Aarhus University Hospital. The study appears in the December issue of the American Journal of Physiology-Renal Physiology published by the American Physiological Society.

Urine output is controlled, in part, by our own internal daily clocks, or circadian rhythm. With the transition from day to night, our bodies reduce the amount of excreted water, electrolytes and other metabolic end products in preparation for hours of sleep. We are not born with this circadian rhythm, but it usually develops in early childhood.

Some children take longer to develop this rhythm, which is why about 15% of enuretic children will spontaneously stop bedwetting each year without any intervention or treatment. The condition affects 7-10 percent of 7-year-old children, but some severe cases linger much longer. As many as 2 percent of young adults have the problem, which may persist for life.

In a psychological sense, enuresis takes a severe toll, and is among the conditions children worry about most, Rittig said. When asked to imagine the worst things that could happ
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