Navigation Links
Higher Trans Fat Levels in Blood Associated With Elevated Risk of Heart Disease

Boston, MA -- High consumption of trans fat, found mainly in partially hydrogenated vegetable oils and widely used by the food industry//, has been linked to an increased risk of coronary heart disease (CHD). New York and Philadelphia have passed measures eliminating its use in restaurants, and other cities are considering similar bans. A new study from the Harvard School of Public Health (HSPH) provides the strongest association to date between trans fat and heart disease. It found that women in the U.S. with the highest levels of trans fat in their blood had three times the risk of CHD as those with the lowest levels. The study was published online on March 26, 2007, and will appear in the April 10, 2007 print issue of Circulation: Journal of the American Heart Association.

“The strength of this study is that the amount of trans fatty acid levels was measured in blood samples from the study population. Because humans cannot synthesize trans fatty acids, the amount of trans fat in red blood cells is an excellent biomarker of trans fat intake,” said senior author Frank Hu, associate professor of nutrition and epidemiology at HSPH.

Clinical trials have shown that trans fatty acids increase LDL cholesterol and lower HDL cholesterol, making them the only class of fatty acids, which includes saturated fat, to have this dual effect. HDL (high-density lipoprotein) is considered a “good” cholesterol; LDL (low-density lipoprotein) a “bad” cholesterol.

The researchers, led by Hu and lead author Qi Sun, a graduate research assistant at HSPH, set out to test the assumption that higher trans fatty acid levels in erythrocytes—red blood cells—were associated with a higher risk of heart disease among U.S. women. Blood samples collected in 1989 and 1990 from 32,826 participants in the Brigham and Women’s Hospital-based Nurses’ Health Study were examined. During six years of follow-up, 166 cases of CHD were diagnosed and matched with 327 controls for age, smoking status, fasting status and date of blood drawing.

After adjusting for age, smoking status and other dietary and lifestyle cardiovascular risk factors, the researchers found that a higher level of trans fatty acids in red blood cells was associated with an elevated risk of CHD. The risk among women in the top quartile of trans fat levels was triple that of the lowest quartile. “Positive associations have been shown in earlier studies based on dietary data provided by the participants, but the use of biomarkers of trans fatty acids is believed to be more reliable than self-reports. This is probably the reason why we see an even stronger association between blood levels of trans fat and risk of CHD in this study,” said Sun.

“These data provide further justifications for current efforts to remove trans fat from foods and restaurant meals,” said Hu. “Trans fat intake in the U.S. is still high. Reducing trans fat intake should remain an important public health priority.”

The study was supported by the National Institutes of Health.

“A Prospective Study of Trans Fatty Acids in Erythrocytes and Risk of Coronary Heart Disease,” Qi Sun, Jing Ma, Hannia Campos, Susan E. Hankinson, JoAnn E. Manson, Meir J. Stampfer, Kathryn M. Rexrode, Walter C. Willett, Frank B. Hu, Circulation, April 10, 2007.

Source-Bio-Bio echnology
SRM
'"/>




Related medicine news :

1. Higher Risk of Asthma in children with autoimmune disease
2. Death Risk Higher in Obese Women with Colon Cancer
3. Women With Diabetes Have a Higher Risk of Depression
4. Individuals Born In May At A Higher Risk Of Developing Multiple Sclerosis
5. Higher Statin Dose Safely Reduces Stroke and Cardiac Arrest
6. Premature Babies More Likely If Women Have Higher Protein Albumin In Urine
7. HIV Infection Higher In Drug Trafficking Countries
8. Higher incidence of bile duct injury during laparoscopic cholecystectomy
9. Math Learning Disorder Higher in Boys
10. Math Learning Disorder Higher In Boys
11. Tall Children Have An Higher IQ
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2017)... , ... March 27, 2017 , ... ... organization behind the New England Journal of Medicine and NEJM Journal Watch, announces ... Pediatrics Board Review was created by a panel of pediatricians from leading medical ...
(Date:3/27/2017)... Birmingham, Clarkston, and Lake Orion, Michigan (PRWEB) , ... ... ... can affect weight loss results. The comprehensive weight management program at Women’s ... begins with an initial evaluation and physical exam. The specialists at ...
(Date:3/27/2017)... Mateo, CA (PRWEB) , ... March 27, 2017 , ... Janet Schloz is still in ... of the best days I’ve had in a long time,” she said. , She thinks ... lot of money that I never thought I would have to help my students.” , ...
(Date:3/27/2017)... ... March 27, 2017 , ... ?Grow Healthy Vending ... the pending litigation between itself and 1800 Vending DBA Healthy You Vending. (Civil ... am thrilled to announce that we have now reached a settlement agreement regarding ...
(Date:3/26/2017)... (PRWEB) , ... March 26, 2017 , ... ... worldwide to receive the RealSelf 100 Award, a prestigious award honoring the top ... procedures and to find and connect with doctors and clinics. , In 2016, ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... Columbia, March 27, 2017  Sophiris Bio Inc. ... "Sophiris"), a clinical late-stage biopharmaceutical company developing topsalysin ... diseases, today reported fourth quarter and full year ... Key Corporate Highlights: ... Prostate Cancer. During 2016, the Company reported successful ...
(Date:3/27/2017)... , March 27, 2017   Pulmatrix, Inc . (NASDAQ: ... to address serious pulmonary diseases, today announced that it has ... cystic fibrosis and asthma to its Scientific Advisory Board ... Richard B. Moss , MD, former chief of ... the Cystic Fibrosis Center at Stanford University, and ...
(Date:3/27/2017)... 2017  iCAD (Nasdaq: ICAD), an industry-leading provider ... therapy for the early identification and treatment of ... Premarket Approval (PMA) from the U.S. Food and ... first-of-its-kind, concurrent-read computer aided detection solution for digital ... available on the PowerLook® Breast Health Solutions platform.  ...
Breaking Medicine Technology: