Navigation Links
High-dose Inhaled Corticosteroid Use for COPD Could Cut Risk of Lung Cancer

Among a group of mostly older male veterans suffering from chronic obstructive pulmonary disease (COPD),// an illness that offers a greater susceptibility to lung cancer, researchers found that regular use of high dose inhaled corticosteroids (ICS) lowered the risk of developing lung cancer.

The results for this study appear in the first issue for April 2007 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

David H. Au, M.D., M.S., of the Veterans Administration Puget Sound Health Care System in Seattle, along with five associates found that among 10,474 patients with COPD, 517 were considered regular users of ICS.

Among users of more than 1,200 micrograms of ICS per day, the relative risk for lung cancer was lowered to 0.39. For users of less than 1,200 micrograms per day, the relative risk was 1.13. (A relative risk of 1 means there is no difference in risk between two groups.)

Over the next four years, the researchers found that among a total of 9,957 nonusers of ICS, 402 developed lung cancer. For 298 users of ICS at a level below 1,200 micrograms per day, 16 developed lung cancer. Among 219 patients who used over 1,200 micrograms per day, five developed lung cancer.

"Lung cancer is the most common cause of cancer-related death in the United States and accounts for more deaths each year than breast, prostate and colon-rectal cancer combined," said Dr. Au. "Studies such as the Lung Health Study have demonstrated that the most common cause of death among subjects with COPD is lung cancer."

In 2004, more than 11 million U.S. adults were estimated to suffer from COPD, which results from chronic bronchitis and emphysema, two inflammatory lung diseases that frequently co-exist and interfere with normal breathing. Smoking is the primary cause of COPD.

"Tobacco smoke is a well-recognized stimulant of systemic and local inflammation and the role of inflammation in the causal pathway for both lung cancer and COPD has been suggested," said Dr. Au.

The researchers noted that ICS have been shown in prospective studies to suppress systemic markers of inflammation such as C-reactive protein and to reduce airway inflammation.

They hypothesized that higher doses of ICS among the male veterans reduced such factors as local airway inflammation, cell turnover, and the propagation of genetic errors. Consequently, these effects could lead to a subsequent reduction in lung cancer risk.

In an editorial on the research in the same issue of the journal, York E. Miller, M.D., of the Denver Veterans Affairs Medical Center, and Robert L. Keith, M.D., of the University of Colorado Cancer Center, Denver, wrote: "Although the data at present are certainly not definitive, inhaled corticosteroids deserve further consideration for lung cancer chemoprevention. Adequately powered, prospective, controlled trials with prolonged follow-up to capture effects on a carcinogenic process that progresses over years will ultimately be needed to determine efficacy. If these could be designed to capture outcomes of interest relevant to both lung cancer and COPD, joint funding by the National Cancer Institute and the National Heart Lung Blood Institute would then be desirable."

"The risk reduction suggested by the studies discussed would be a clinically significant achievement, particularly in light of the continued lung cancer epidemic," the editorialists continued. "Many additional agents are undergoing evaluation for lung cancer chemoprevention, including micronutrients, tyrosine kinase inhibitors, and blockers or agonists of signaling pathways as reviewed. It is hoped, within the next decade, that chemoprevention of lung cancer in high-risk individuals (beyond smoking cessation) will be standard in pulmonary and primary care settings as is influenza vaccination or cardiac risk factor modificatio n. The potential for benefit is just as great."

Source-Eurekalert
'"/>




Related medicine news :

1. The Link Between High-dose Steroid Use And Heart Disease Questioned
2. Low-dose Aspirin Beats High-dose After Cardiac Surgery
3. Inhaled Steroids Safe & Effective for Children with Asthma
4. Inhaled Corticosteroids Found To Have No Significant Effect On COPD
5. The Effectiveness Of Inhaled Corticosteroids Studied
6. The Effectiveness Of Inhaled Corticosteroids Studied
7. Inhaled nitric oxide therapy does not reduce death risk of infants
8. New Drug Exubera (Oral Inhaled Insulin) To Be Monitored By Pfizer
9. HIIP- A Novel Inhaled Insulin Delivery System As An Alternative To Injectable Insulin Therapy
10. Inhaled Insulin To Be Made Available in India
11. Inhaled Insulin Could Rock The Drug Market Soon
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of ... ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership in ... It also provides a forum to network with elder law attorneys nationwide,” said Somekh. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers ... companies have a waiver for care if the client has a cognitive impairment diagnosis. ... pays for care, is often waived, so the benefits from their insurance start immediately,” ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional women, ... towards gender equality at their inaugural Summit in New York City in June. The ... social audience of over 3 million. To watch the Mobilize Women video, click ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released a ... books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture of ... have tossed it off as mere rubbish, but Yisrayl Hawkins says that is because ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in ... awarded a contract by the Center for Medicare and Medicaid Services (CMS). The ... enterprise use of Agile methodologies in a consistent and high value manner across ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... Calif. , Oct. 10, 2017  NDS received FDA 510(k) ... — a medical-grade battery-powered display stand specifically designed for endoscopy environments. ... transform technology into a clinical solution to support the improvement of ... Innovative Design ... Mobile Wireless Solution ...
(Date:10/5/2017)... Oct. 5, 2017  In response to the ... and Maxillofacial Surgeons (AAOMS) released prescribing recommendations that ... be used as a first-line therapy to manage ... Recognizing the value and ... Paper "Opioid Prescribing: Acute and Postoperative Pain Management" ...
(Date:10/4/2017)... 2017 OBP Medical , a ... devices, today announced regulatory approval from ... Agência Nacional de Vigilância Sanitária (ANVISA)) to market ... retractor with integrated LED light source and smoke ... exposure of a tissue pocket or cavity during ...
Breaking Medicine Technology: