Navigation Links
High Pretreatment PSA Velocity Predicts Worse Outcome

The most significant single predictor of aggressive prostate cancer is an elevated rate of increase in prostate specific antigen (PSA) levels, according to a new study. The study found that a pre-treatment rate of PSA increase, called PSA velocity, of more than 2 ng/ml/year was strongly associated with a high risk of death from prostate cancer. Elevated PSA velocity was a stronger poor prognostic factor than any other single high-risk indicator, such as a biopsy Gleason score greater than 7, a PSA level of 10 ng/ml or an advanced disease category.

Prostate cancer is expected to be diagnosed in more than 200,000 American men in the U.S. this year and cause more than 27,000 deaths, the leading cause of cancer death after lung cancer in U.S. men. Most tumors are slow growing and asymptomatic, and the disease affects primarily men over 50 years old. As a result, most men diagnosed with prostate cancer die of other age-related causes.

However, in a significant subset of prostate cancer patients, the cancer will be aggressive and quick enough to cause morbidity and death. Identifying these men is critical to reducing deaths from prostate cancer. Researchers have identified several indicators with the potential to identify high-risk patients and developed various algorithms, using such factors as the microscopic features of the tumor (i.e., Gleason score), size, spread of the disease, and location of disease, to determine prognosis. However, recent trends suggest that these factors are not effective and that better indicators are needed. Calculating PSA velocity has shown promise as a prognostic indicator. Studies suggest that PSA velocity more than 2 ng/ml/year strongly suggests aggressive disease. Understanding its significance after treatment, particularly relative to other risk factors, is critical to identifying high-risk patients.

Dr. Anthony DAmico of Bostons Brigham and Womens Hospital and co-investigators characterized P SA velocity significant in prostate cancer-specific mortality (PCSM) rates following treatment with radical prostatectomy (RP) or radiation therapy (RT). Dr. DAmico reviewed data from 948 men with localized prostate cancer who had one or more high-risk factors.

Dr. DAmico and his co-authors found that the most important single prognostic factor was PSA velocity. As expected, men who had multiple risk factors died from their disease significantly earlier than those with one factor. Of the men who underwent treatment with RP or RT, 44 percent and 28 percent, respectively, had pre-treatment PSA velocities of > 2 ng/ml/year as their only identified high-risk factor. Of those men who died with only one identified high-risk factor, 88 percent of RP-treated patients and 80 percent of RT-treated patients had pre-treatment PSA velocities of > 2 ng/ml/year.

In identifying this association, the authors also point out that other studies have found that time to death shortens as PSA velocity increases. This suggests that further research should examine using stratified PSA velocities to assess risk in men with localized disease.

"These findings," conclude the authors, "highlight the ability of a pre-treatment PSA velocity > 2 ng/ml/year alone to identify men with aggressive prostate cancer and in whom effective systemic treatment in addition to mono-therapy with RP or RT is needed to decrease PCSM rates."


'"/>




Related medicine news :

1. Restricted Activity Predicts Disability
2. Fitness Level Predicts Stroke
3. PSA Can Predicts The Treatment Response In Advanced Prostate Cancer
4. Being Teased Predicts Poor Psychological Functioning in Youth With Cleft Lip
5. Model Predicts Colon Cancer Inheritable Genetic Defects
6. Formula Predicts Osteoporotic Fracture Risk
7. Computer Tool Predicts Effectiveness Of Microbicides
8. New Genetic Test Predicts Eye-Cancer Patients Futures
9. Technology Predicts Outcome of Child Heart Surgery
10. A Secret Dossier Predicts Major Changes At NHS, England
11. Activation of a Particular Brain Region Predicts Altruism: Study
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/30/2016)... ... April 30, 2016 , ... Create ... Abstract users can distort and manipulate three-dimensional shapes with ease all within ... ranks, point, lines, polygons, polygon texture animation, opacity texture animation, overall shape texture ...
(Date:4/30/2016)... , ... April 30, 2016 ... ... CBC News on April 4th, 2016 questioned the use of the HyProCure ... EOTTS-HyProCure as “a controversial procedure.” EOTTS-HyProCure is a minimally invasive procedure performed, ...
(Date:4/29/2016)... ... April 29, 2016 , ... In an article published April ... enthusiasm for Botox and lip injections, which she underwent in order to feel more ... Music and Arts Festival. The article explains that Ms. Mirmelli’s situation is not unique; ...
(Date:4/29/2016)... ... April 29, 2016 , ... On Tuesday, April 26, 2016 members of the ... signature of Gov. Nathan Deal on SB 258, the “Rural Health Care Relief” Bill. ... a 70% tax credit to individuals and corporations which donate directly to a “rural ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... Coast Dental ... 16, 2016, at its new location in the Exchange Furniture Mall at 112 Vilseck ... for a 50-inch Samsung Smart TV. Plus attendees will have the opportunity to meet ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... 2016 Automation is one of ... to the growing demands for productivity in speed, accuracy, ... systems are already adept of a wide range of ... manual labor. Instrumentation continues to evolve, and is poised ... a few years ago. Originally used mostly by the ...
(Date:4/28/2016)... April 28, 2016  While Abbott,s announced purchase ... company,s valve repair and stent business, healthcare research ... Abbott more firmly into patient monitoring.  Kalorama said ... growing device areas, with double-digit growth expected the ... Advanced Remote Patient Monitoring . Abbott ...
(Date:4/28/2016)... April 28, 2016  Marking its one year ... and ovarian cancer risk test, Color Genomics ... genes that highly impact the most common hereditary ... the Color Test analyzes hereditary cancer risks for ... uterine cancers. The Color Test is physician ordered ...
Breaking Medicine Technology: