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High Nonfasting Triglyceride Levels Linked With Cardiovascular Risks

attack increased for each higher category of triglyceride levels (from 1-mmol/L to greater than 5-mmol/L), with the increase in risk (adjusted for other factors) ranging from 1.7 times to 5.4 times, compared to those with triglyceride levels of less than 1-mmol/L.

For men, the increased adjusted risk for heart attack for each higher category of triglyceride levels ranged from 1.4 to 2.4. Risk of IHD and death also generally increased with higher triglyceride levels.

We found that nonfasting triglyceride levels independently predict MI, IHD, and death particularly in women. These findings may reflect the effects of remnant lipoproteins and therefore may be of considerable interest when designing future trials of agents aimed at reducing triglyceride levels or attenuating atherogenic metabolic abnormalities.

If our findings are confirmed, clinical care might be simplified by using nonfasting lipid profiles for atherosclerosis risk prediction, the researchers conclude.

Contact the JAMA/Archives Media Relations Department at 312-464-JAMA or email: mediarelations@jama-archives.org.


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