Navigation Links
High Doses of Lithium-Like Drugs May Impair Neuronal Function

New laboratory research suggests that lithium and other drugs that inhibit a particular enzyme, GSK-3 beta, should be used with caution in treating Alzheimer's disease// because too high a dose can impair, rather than enhance, neuronal function.

Lithium is currently in clinical trials for treating Alzheimer's. Pharmaceutical companies are interested in producing other GSK-3 beta inhibitors for the disease because these drugs are relatively easy to make and lithium has been shown to be safe in low doses in treating people with manic-depressive illness, said Dr. William D. Snider, professor of neurology, cell and molecular physiology at the University of North Carolina at Chapel Hill's School of Medicine.

"People might think that if you make the inhibitor stronger and stronger, that would be better. Our in-vitro experiments show that you will have to be careful with how you use GSK-3 beta inhibitors, because if you use too much, it will interfere with and possibly kill neurons," said Snider, who also is director of UNC's Neuroscience Center.

The results, published online Thursday (Dec. 21) in the journal Neuron, were surprising because GSK-3 beta inhibitors have been shown at some doses to improve neuronal function. "It's known that when GSK-3 beta is inactivated that tends to allow the processes inside the cell it regulates to function normally," Snider said.

But when the researchers strongly inhibited GSK-3 beta in mouse neurons in cell culture, the growth of axons, which carry messages between nerve cells, was markedly reduced.

The researchers inhibited GSK-3 beta using RNA silencing. "RNA silencing allows you to specifically knock down the level of a particular protein inside the cell," Snider said.

In a second set of experiments, the researchers treated mouse neurons with a low dose and a high dose of a GSK-3 beta inhibitor similar to lithium. The high dose impaired neuronal function, while t he low dose improved it.

Source-Newswise
'"/>




Related medicine news :

1. India To Procure 1 Million Doses Of Tamiflu
2. Small Doses Of Radiation Can Help Certain Lung Cancer Patients
3. Polyphenols in Green Tea Cause Liver Damage At High Doses
4. Pre-eclampsia Pronounced With Intake of Vitamins in Large Doses
5. Stronger Doses Fewer Administration for Breast Cancer
6. High Doses Of Common Pain killers Can Double The Chances Of Heart attack
7. Even Normal Doses Of Tylenol Could Damage Liver
8. Allergic Individuals Should Carry Two Doses Of EpiPen Says Quebec Coroner
9. Reduced Doses of Medication Beneficial to Preschoolers with ADHD
10. Low Doses of Anti-Depressant May Help PMS
11. Low Doses Of Arsenic Have Broad Impact On Hormone Activity – Says A Researc
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... ... ... Brand EXOUS Bodygear announced today a special sale price for the EX-701 Knee ... the price will be only $19.97. The EXOUS Bodygear 65cm exercise ball ... $19.97). , The special promotional prices are to help individuals get their products at ...
(Date:3/29/2017)... ... March 29, 2017 , ... Based ... into the challenges employers face in trying to balance both short-term and long-term ... programs? Adding to the growing complexity, companies are finding that the short-term ...
(Date:3/29/2017)... , ... March 29, 2017 , ... ... buildings (MOBs) and other outpatient facilities, and who are the most active developers? ... those questions, Revista and Healthcare Real Estate Insights (HREI) found that outpatient medical ...
(Date:3/29/2017)... ... March 29, 2017 , ... HealthCareMandA.com will host an ... 20, 2017, at 1:00 PM ET. A recording of the webinar will also be ... Series. , Home health and hospice companies are still popular targets for healthcare investors. ...
(Date:3/29/2017)... ... March 29, 2017 , ... ... now have easier access to the robotic-assisted total-hip and partial-knee replacement surgeries ... Orthopaedic surgeons at Forbes Hospital and Jefferson Hospital recently started performing these ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... 2017  The leader in accelerated orthodontics, OrthoAccel ® ... Daher , Manal Ibrahim , Kenji Ojima ... be the featured microlecture presenters at the AcceleDent ® ... Orthodontists (AAO) Annual Session, April 21-25, 2017. Orthodontists and ... daily at 11:20 a.m. On the opening morning of ...
(Date:3/29/2017)... , March 29, 2017  Glenmark Pharmaceuticals, ... for GSP 301, an investigational fixed-dose combination of ... mcg) administered twice-daily as a nasal spray being ... These results are from a recently completed Phase ... GSP 301 combination therapy versus mometasone, olopatadine or ...
(Date:3/29/2017)... 29, 2017 Transparency Market ... provides an exhaustive study of the U.S. substance abuse ... companies are functional in this market at present, ... leading companies, such as GlaxoSmithKline Plc., Pfizer Inc., ... on various marketing strategies to increase their visibility, ...
Breaking Medicine Technology: