Navigation Links
High Dose Inhaled Corticosteroid Use for COPD Could Cut Risk of Lung Cancer

Among a group of mostly older male veterans suffering from chronic obstructive pulmonary disease (COPD), an illness that offers a greater// susceptibility to lung cancer, researchers found that regular use of high dose inhaled corticosteroids (ICS) lowered the risk of developing lung cancer.

David H. Au, M.D., M.S., of the Veterans Administration Puget Sound Health Care System in Seattle, along with five associates found that among 10,474 patients with COPD, 517 were considered regular users of ICS.

Among users of more than 1,200 micrograms of ICS per day, the relative risk for lung cancer was lowered to 0.39. For users of less than 1,200 micrograms per day, the relative risk was 1.13. (A relative risk of 1 means there is no difference in risk between two groups.)

Over the next four years, the researchers found that among a total of 9,957 nonusers of ICS, 402 developed lung cancer. For 298 users of ICS at a level below 1,200 micrograms per day, 16 developed lung cancer. Among 219 patients who used over 1,200 micrograms per day, five developed lung cancer.

“Lung cancer is the most common cause of cancer-related death in the United States and accounts for more deaths each year than breast, prostate and colon-rectal cancer combined,” said Dr. Au. “Studies such as the Lung Health Study have demonstrated that the most common cause of death among subjects with COPD is lung cancer.”

In 2004, more than 11 million U.S. adults were estimated to suffer from COPD, which results from chronic bronchitis and emphysema, two inflammatory lung diseases that frequently co-exist and interfere with normal breathing. Smoking is the primary cause of COPD.

“Tobacco smoke is a well-recognized stimulant of systemic and local inflammation and the role of inflammation in the causal pathway for both lung cancer and COPD has been suggested,” said Dr. Au.

The researchers noted that ICS have been shown in prospectiv e studies to suppress systemic markers of inflammation such as C-reactive protein and to reduce airway inflammation.

They hypothesized that higher doses of ICS among the male veterans reduced such factors as local airway inflammation, cell turnover, and the propagation of genetic errors. Consequently, these effects could lead to a subsequent reduction in lung cancer risk.

In an editorial on the research in the same issue of the journal, York E. Miller, M.D., of the Denver Veterans Affairs Medical Center, and Robert L. Keith, M.D., of the University of Colorado Cancer Center, Denver, wrote:

“Although the data at present are certainly not definitive, inhaled corticosteroids deserve further consideration for lung cancer chemoprevention. Adequately powered, prospective, controlled trials with prolonged follow-up to capture effects on a carcinogenic process that progresses over years will ultimately be needed to determine efficacy. If these could be designed to capture outcomes of interest relevant to both lung cancer and COPD, joint funding by the National Cancer Institute and the National Heart Lung Blood Institute would then be desirable.”

“The risk reduction suggested by the studies discussed would be a clinically significant achievement, particularly in light of the continued lung cancer epidemic,” the editorialists continued. “Many additional agents are undergoing evaluation for lung cancer chemoprevention, including micronutrients, tyrosine kinase inhibitors, and blockers or agonists of signaling pathways as reviewed. It is hoped, within the next decade, that chemoprevention of lung cancer in high-risk individuals (beyond smoking cessation) will be standard in pulmonary and primary care settings as is influenza vaccination or cardiac risk factor modification. The potential for benefit is just as great.”

Source-Newswie
SRM/L
'"/>




Related medicine news :

1. Inhaled Steroids Safe & Effective for Children with Asthma
2. Inhaled Corticosteroids Found To Have No Significant Effect On COPD
3. The Effectiveness Of Inhaled Corticosteroids Studied
4. The Effectiveness Of Inhaled Corticosteroids Studied
5. Inhaled nitric oxide therapy does not reduce death risk of infants
6. New Drug Exubera (Oral Inhaled Insulin) To Be Monitored By Pfizer
7. HIIP- A Novel Inhaled Insulin Delivery System As An Alternative To Injectable Insulin Therapy
8. Inhaled Insulin To Be Made Available in India
9. Inhaled Insulin Could Rock The Drug Market Soon
10. High Cost Forces NHS To Reject Inhaled Insulin
11. Inhaled Cyclosporine Results In Rejection Free Survival among Lung Transplant Patients
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... ... March 28, 2017 , ... ... the first technology to directly address the resolution to globally reduce the harmful ... a patented compound of FDA and TTB approved ingredients that when infused into ...
(Date:3/28/2017)... ... March 28, 2017 , ... Resoundant, Inc., the developer of ... Siemens Healthineers annual customer education symposium, a world-class learning conference that offers educational ... 27 - 31, 2017 at the Atlanta Marriott Marquis in Atlanta, Georgia. , ...
(Date:3/28/2017)... ... March 29, 2017 , ... The Thyroid Secret is a ... FASCP. The program was recently launched on March 1, and Dr. Wentz discussed ... , Dr. Izabella Wentz is a licensed pharmacist and a foremost thyroid ...
(Date:3/28/2017)... Seattle, WA (PRWEB) , ... March 28, 2017 ... ... reach a 22% share of all holidays (IBT World Travel Trends Report). As ... physically challenging, include a range in temperatures, and prolonged sun exposure. In response, ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... advancing the science and clinical practice of radiosurgery, announced today the publication ... multi-institutional, observational registry established to standardize data collection from patients treated with ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... 2017 The global emerging cancer diagnostics market ... from 2016 to 2023 and reach a figure of ... is a chronic disease and is affecting a huge ... market. This report is focused on emerging cancer diagnostics ... is propelled due to factors such as: increasing number ...
(Date:3/28/2017)... 2017  Medeon Biodesign, Inc., a ... to announce that the Company led and successfully ... Inc., a San Jose, CA ... orthopedic extremity applications.  The orthopedic ... due to procedure volume growth, lifestyle influences and ...
(Date:3/28/2017)... -- "US Cancer Generics Market Outlook 2022" report gives ... analysis related to the emergence and integration of ... US. The report analyzes various clinical and non-clinical ... drugs in recent years. The introduction of generics ... for various stake holders involved US cancer drug ...
Breaking Medicine Technology: